Journal ArticleDOI
Lactate dehydrogenase downregulation mediates the inhibitory effect of diallyl trisulfide on proliferation, metastasis, and invasion in triple-negative breast cancer
Shi Yann Cheng,Yao Chih Yang,Kuan Lun Ting,Su Ying Wen,Vijaya Padma Viswanadha,Chih Yang Huang,Wei Wen Kuo +6 more
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TLDR
The study shows that LDHA downregulation is involved in the apoptotic effect of DATS on TNBC, suggesting that DATS inhibits breast cancer growth and aggressiveness through a novel pathway targeting the key enzyme of the Warburg effect.Abstract:
The Warburg effect plays a critical role in tumorigenesis, suggesting that specific agents targeting Warburg effect key proteins may be a promising strategy for cancer therapy. Previous studies have shown that diallyl trisulfide (DATS) inhibits proliferation of breast cancer cells by inducing apoptosis in vitro and in vivo. However, whether the Warburg effect is involved with the apoptosis-promoting action of DATS is unclear. Here, we show that the action of DATS is associated with downregulation of lactate dehydrogenase A (LDHA), an essential protein of the Warburg effect whose upregulation is closely related to tumorigenesis. Interestingly, inhibition of the Warburg effect by DATS in breast cancer cells did not greatly affect normal cells. Furthermore, DATS inhibited growth of breast cancer cells, particularly in MDA-MB-231, a triple-negative breast cancer (TNBC) cell, and reduced proliferation and migration; invasion was reversed by over-expression of LDHA. These data suggest that DATS inhibits breast cancer growth and aggressiveness through a novel pathway targeting the key enzyme of the Warburg effect. Our study shows that LDHA downregulation is involved in the apoptotic effect of DATS on TNBC. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1390-1398, 2017.read more
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Pkcδ Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products (Ages).
Yao Chih Yang,Cheng Yen Tsai,Chien Lin Chen,Chia-Hua Kuo,Chien-Wen Hou,Shi Yann Cheng,Ritu Aneja,Chih Yang Huang,Wei Wen Kuo +8 more
TL;DR: The findings indicated that cardiac PKCδ activation mediates AGE-BSA-induced cardiomyocyte apoptosis via ROS production and may play a key role in the development of cardiac mitochondrial dysfunction in rats with diabetes and obesity.
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Diallyl disulfide and diallyl trisulfide in garlic as novel therapeutic agents to overcome drug resistance in breast cancer
TL;DR: In this article , a review of the potential anticancer activities of DADS and DATS, with emphasis on drug resistance in triple-negative breast cancer (TNBC), is presented, which provides insights into their potential in targeting drug resistance mechanisms of TNBC, especially in clinical studies.
Journal ArticleDOI
Diallyl disulfide and diallyl trisulfide in garlic as novel therapeutic agents to overcome drug resistance in breast cancer
TL;DR: In this article, the potential anticancer activities of DADS and DATS, with emphasis on drug resistance in triple-negative breast cancer (TNBC), were discussed, and their potential in targeting drug resistance mechanisms of TNBC, especially in clinical studies.
Journal ArticleDOI
The rate of aerobic glycolysis is a pivotal regulator of tumor progression
Mohammad Erfan Zare,Atefeh Nasir Kansestani,Shahrooz Hemmati,Kamran Mansouri,Asad Vaisi-Raygani +4 more
TL;DR: In this article, different glucose accessibility conditions on the rate of Warburg effect and its impact on Hypoxia inducible factors-1α (HIF-1 α)/vascular endothelium growth factor (VEGF) pathway in breast cancer cells lines were investigated.
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The pan‐cancer analysis of the oncogenic role of FAM72A as a BRCA prognostic biomarker and immunotherapeutic target
TL;DR: In this article , the role of FAM72A in breast cancer (BC) was so conspicuous that they analyzed the prognostic significance and clinicopathological parameter's relevance, and they also validated biological functions by applying in vitro experiments.
References
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