Lactoferrin: a general review
TLDR
A wide spectrum of functions are ascribed to lactoferrin, which range from a role in the control of iron availability to immune modulation, and more research is necessary to obtain clarity with regard to the exact mechanism of action.Abstract:
Lactoferrin is a 703-amino acid glycoprotein originally isolated from milk Plasma lactoferrin is predominantly neutrophil derived but indications are that it may also be produced by other cells Lactoferrin in body fluids is found in the iron-free form, the monoferric form and in the diferric form Three isoforms of lactoferrin have been isolated, ie two with RNase activity (lactoferrin-beta and lactoferrin-gamma) and one without RNase activity (lactoferrin-alpha) Receptors for lactoferrin can be found on intestinal tissue, monocytes/macrophages, neutrophils, lymphocytes, platelets, and on certain bacteria A wide spectrum of functions are ascribed to lactoferrin These range from a role in the control of iron availability to immune modulation More research is necessary however to obtain clarity with regard to the exact mechanism of action of lactoferrinread more
Citations
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Contribution of neutrophils to acute lung injury.
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Drug delivery via the transferrin receptor-mediated endocytosis pathway
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Tryptophan- and arginine-rich antimicrobial peptides: structures and mechanisms of action.
TL;DR: In this review, the structures of a number of different Trp- and Arg-rich antimicrobial peptides are examined and some of the major mechanistic studies are presented.
Journal ArticleDOI
Lactoferrin--a multifunctional protein with antimicrobial properties.
TL;DR: Its extensive antimicrobial activities were originally attributed to its ability to sequester essential iron, however, it is now established that it possesses bactericidal activities as a result of a direct interaction between the protein or lactoferrin-derived peptides.
References
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The phenomenon of the acute phase response
TL;DR: Avery never discussed the C-reactive protein without turning the conversation to what he was wont to call “the chemistry of the host,” which clearly had in mind all the unidentified body substances and mechanisms of a nonimmunological nature that come into play in the course of infectious processes.
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A bactericidal effect for human lactoferrin
TL;DR: Streptococcus mutans and Vibrio cholerae, but not Escherichia coli, were killed by incubation with purified human apolact oferrin, contingent upon the metal-chelating properties of the lactoferrin molecule.
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Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin
TL;DR: Lactoferricin B was lethal, causing a rapid loss of colony-forming capability in most of the species tested, and Pseudomonas fluorescens, Enterococcus faecalis and Bifidobacterium bifidum strains were highly resistant to this peptide.