Journal ArticleDOI
Large-scale stereoselective enzymatic ketone reduction with in situ product removal via polymeric adsorbent resins
Jeffrey Thomas Vicenzi,Milton J. Zmijewski,Reinhard Matthew Robert,Bryan E. Landen,Muth William Lawrence,Paul G. Marler +5 more
TLDR
The NAD(P)H-dependent enzymatic activity within living Zygosaccharomyces rouxii was utilized to accomplish this reaction and the reaction was scaled-up to a volume of 300 l by utilizing a commercially available agitated filter as a reactor.About:
This article is published in Enzyme and Microbial Technology.The article was published on 1997-05-15. It has received 101 citations till now. The article focuses on the topics: Yield (chemistry) & Enantiomeric excess.read more
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Role of Biocatalysis in Sustainable Chemistry
Roger A. Sheldon,John M. Woodley +1 more
TL;DR: Based on the principles and metrics of green chemistry and sustainable development, biocatalysis is both a green and sustainable technology and its broader application will be further stimulated in the future by the emerging biobased economy.
Journal ArticleDOI
The production of fine chemicals by biotransformations.
TL;DR: An analysis of 134 industrial biotransformations reveals that hydrolases and redox biocatalysts are the most prominent categories and the implications of this for future research and development onBiocatalysis are discussed.
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Biocatalysis for pharmaceutical intermediates: the future is now
David Pollard,John M. Woodley +1 more
TL;DR: This review describes how demands are being addressed to make biocatalysis successful, particularly by the use of micro-scale technology for high-speed catalyst screening and process development alongside discipline integration of biology and engineering with chemistry.
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Baeyer-Villiger monooxygenases: more than just green chemistry.
TL;DR: This dissertation aims to provide a history of web exceptionalism from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “Web 2.0” began to circulate.
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Whole-cell biocatalysis in organic media
TL;DR: Correlations between the cellular toxicity or the extractive capacities of different solvents and some of their physical properties have been proposed in order to minimize preliminary, solvent-selection experimental work but also to help in the understanding of the molecular mechanisms of toxicity and extraction.
References
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Continuous enzymatic transformation in an enzyme membrane reactor with simultaneous NAD(H) regeneration: CONTINUOUS ENZYMATIC TRANSFORMATION
TL;DR: Multienzyme reaction systems with simultaneous coenzyme regeneration have been investigated in a continuously operated membrane reactor at bench scale to obtain data which could be used in a kinetic model in order to predict the performance of an enzyme membrane reactor for the continuous production of L‐leucine.
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Solvent selection strategies for extractive biocatalysis.
TL;DR: Methods to predict the biocompatibility and extractant capability of solvents are discussed and a computer program, known as the extractant screening program or ESP, has been developed to effectively predict the behavior of virtually any product in any solvent/aqueous system.
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Toxicity of homologous series of organic solvents for the gram-positive bacteria Arthrobacter and Nocardia Sp. and the gram-negative bacteria Acinetobacter and Pseudomonas Sp.
TL;DR: The toxicity of homologous series of organic solvents has been investigated for gram‐positive bacteria, Arthrobacter sp.
Journal ArticleDOI
Continuous enzymatic transformation in an enzyme membrane reactor with simultaneous NAD(H) regeneration
TL;DR: Multienzyme reaction systems with simultaneous coenzyme regeneration have been investigated in a continuously operated membrane reactor at bench scale to obtain data which could be used in a kinetic model in order to predict the performance of an enzyme membrane reactor for the continuous production of L‐leucine.