Lead acetate exposure inhibits nitric oxide synthase activity in capillary and synaptosomal fractions of mouse brain.
TLDR
Data suggest that inhibition of cNOS activity and increase in iNOS may contribute to the Pb effects on the CNS, and the concentration of lead in blood, capillaries and synaptosomes in brain from mice receiving 0, 250, 500, and 1000 ppm of lead for 14 days through the drinking water.About:
This article is published in Toxicological Sciences.The article was published on 1999-08-01 and is currently open access. It has received 26 citations till now. The article focuses on the topics: Lead acetate & Neurotoxicity.read more
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Enhanced brain regional lipid peroxidation in developing rats exposed to low level lead acetate.
Juana Villeda-Hernández,Barroso-Moguel R,Marisela Méndez-Armenta,Concepción Nava-Ruiz,R Huerta-Romero,Camilo Ríos +5 more
TL;DR: Data suggest that in the brain of rats exposed to lead acetate, lead produces a neurotoxic effect with a complex correlation with both lead regional content and lipid peroxidation.
Journal ArticleDOI
Lead neurotoxicity: effects on brain nitric oxide synthase
TL;DR: Evidence is summarized showing that Pb can interfere with the production of nitric oxide and can disrupt the function of Nitric oxide synthase, and Pb neurotoxicity may affect processes involved in learning and memory.
Journal ArticleDOI
Acute exposure to lead acetate activates microglia and induces subsequent bystander neuronal death via caspase-3 activation
Kanhaiya Lal Kumawat,Kanhaiya Lal Kumawat,Deepak Kumar Kaushik,Praveen Goswami,Praveen Goswami,Anirban Basu +5 more
TL;DR: Critical involvement of microglial activation in mediating the neurotoxicity associated with lead exposure is brought forth.
Journal ArticleDOI
Perinatal Lead Exposure Alters the Expression of Neuronal Nitric Oxide Synthase in Rat Brain
Chellu S. Chetty,Gottipolu R. Reddy,Karnam S. Murthy,J. Johnson,Kenneth S. Sajwan,Durisala Desaiah +5 more
TL;DR: The nNOS protein levels and immunoreactivity in the cerebellum and hippocampus of rats perinatally exposed to Pb were decreased as compared to controls at PNDs 21 and 35, suggesting perinatal Pb exposure decreases the nN OS in the developing brain.
Journal ArticleDOI
Thymoquinone ameliorates lead-induced brain damage in Sprague Dawley rats
TL;DR: Treatment of rats with lead acetate was shown to produce degeneration of endothelial lining of brain blood vessels with peri-vascular cuffing of mononuclear cells consistent to lymphocytes, congestion of choroid plexus blood vessels, ischemic brain infarction, chromatolysis and neuronal degeneration, microglial reaction and neuronophagia, degenerations of hippocampal and cerebellar neurons, and axonal demyelination.
References
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal Article
Nitric oxide: physiology, pathophysiology, and pharmacology
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Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
David S. Bredt,Solomon H. Snyder +1 more
TL;DR: It is shown that nitric oxide synthetase activity requires calmodulin, and the native enzyme appears to be a monomer.
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme (endothelium-derived relaxing factor/arginine/cGMP)
David S. Bredt,Solomon H. Snyder +1 more
TL;DR: In this paper, it was shown that NO synthetase is a calmodulin-requiring enzyme, and showed that NO formation is accompanied by the stoichiometric conversion of arginine to citrulline.