Journal ArticleDOI
Lipedema: an overview of its clinical manifestations, diagnosis and treatment of the disproportional fatty deposition syndrome - systematic review.
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TLDR
Early diagnosis and treatment are mandatory for this disorder otherwise gradual enlargement of fatty deposition causes impaired mobility and further comorbidities like arthrosis and lymphatic insufficiency.Abstract:
Lipedema is a disproportionate, symmetrical fatty swelling characterized by pain and bruising existing almost exclusively among women. We undertook a systematic review of the available literature about lipedema, given the lack of knowledge and little evidence about this disorder especially among obesity experts. Diagnosis of lipedema is usually based on clinical features. Symmetrical edema in the lower limbs with fatty deposits located to hips and thighs usually appears at puberty and often affects several members of the same family. Main disorders considered for differential diagnosis are lymphedema, obesity, lipohypertrophy and phlebedema. Treatment protocols comprise conservative (decongestive lymphatic therapy) and surgical (liposuction) approaches. Early diagnosis and treatment are mandatory for this disorder otherwise gradual enlargement of fatty deposition causes impaired mobility and further comorbidities like arthrosis and lymphatic insufficiency.read more
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Journal ArticleDOI
Update in the management of lipedema.
TL;DR: In this article, the authors performed a non-systematic review on the literature related to diagnosis and therapy of lipedema and found that the major aims of the management are multimodal for improvements in the quality of life; reduction in heaviness and pain, reshaping the affected limbs, weight control, improvements in mobility.
Journal ArticleDOI
A Multi-Gene Panel to Identify Lipedema-Predisposing Genetic Variants by a Next-Generation Sequencing Strategy
S Michelini,Karen L. Herbst,Vincenza Precone,Elena Manara,Giuseppe Marceddu,Astrit Dautaj,Paolo Enrico Maltese,Stefano Paolacci,Maria Rachele Ceccarini,Tommaso Beccari,Elisa Sorrentino,Barbara Aquilanti,Valeria Velluti,Giuseppina Matera,Lucilla Gagliardi,Giacinto Abele Donato Miggiano,Matteo Bertelli +16 more
TL;DR: An extended NGS-based approach has identified a number of gene variants that may be important in the diagnosis of lipedema, that may affect the phenotypic presentation of Lipedema or that may cause disorders that could be confused withlipedema.
Journal ArticleDOI
An updated review of the evidence for adjustable compression wrap devices in the lower limb
TL;DR: Compression therapy is a key component in the effective management of people with lower limb problems associated with venous, lymphatic and fat disorders such as lipoedema, and adjustable, compression-wrap devices incorporating hook-and-loop systems present new opportunities for improving treatment outcomes.
Journal ArticleDOI
Hallazgos linfogammagráficos en pacientes con lipedema
TL;DR: Aunque la linfogammagrafia se ha empleado para diferenciar lipedema de linfedema, encontramos alteraciones frecuentes en las pacientes con lipedem, por lo que the presencia of hallazgos no descarta el diagnostico oficial of Lipedema.
Genetic syndromes with localized subcutaneous fat tissue accumulation.
Vincenza Precone,Shila Barati,Stefano Paolacci,Marzia Salgarello,Giuseppe Visconti,Stefano Gentileschi,Giulia Guerri,Lucilla Gagliardi,Barbara Aquilanti,Giuseppina Matera,Valeria Velluti,Giacinto Abele Donato Miggiano,Karen L. Herbst,Matteo Bertelli +13 more
TL;DR: The genes involved in syndromes with localized accumulation of subcutaneous fatty tissue are summarized, the test used for genetic analysis is summarized and the test is described that helps diagnose these disorders.
References
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International statistical classification of diseases and related health problems. Tenth revision.
TL;DR: It is proposed that the chapters on external causes of injury and poisoning, and factors influencing health status and contact with health services, should form an integral part of ICD-10, for the first time in its history based on an alphanumeric coding scheme.
Journal Article
Indications for compression therapy in venous and lymphatic disease consensus based on experimental data and scientific evidence. Under the auspices of the IUP.
Hugo Partsch,Flour M,Smith Pc +2 more
TL;DR: It is shown that whilst good evidence for the use of compression is available in some clinical indications, there is much still to be discovered.
Journal ArticleDOI
Differential diagnosis, investigation, and current treatment of lower limb lymphedema
TL;DR: The common differential diagnosis in Western patients with lower limb swelling is secondary lymphedema, venous disease, lipedema, and adverse reaction to ipsilateral limb surgery.
Journal ArticleDOI
Lipedema: an inherited condition.
Anne H. Child,Kristiana Gordon,Pip Sharpe,Glen Brice,Pia Ostergaard,Steve Jeffery,Peter S. Mortimer +6 more
TL;DR: It is proposed that lipedema is a genetic condition with either X‐linked dominant inheritance or more likely, autosomal dominant inheritance with sex limitation, and appears to be a condition almost exclusively affecting females, presumably estrogen‐requiring as it usually manifests at puberty.