Journal ArticleDOI
Lipid peroxidation in relation to ageing and the role of endogenous aldehydes in diabetes and other age-related diseases.
L.F. Dmitriev,V.N. Titov +1 more
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TLDR
Evidence is provided to consider ageing as a process in which lipid-radical cycles gradually substitute for lipid peroxidation, and to consider endogenous aldehydes as the major initiators of the metabolic disorders.About:
This article is published in Ageing Research Reviews.The article was published on 2010-04-01. It has received 80 citations till now. The article focuses on the topics: Glyoxalase system & Methylglyoxal.read more
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Journal ArticleDOI
DNA damage induced by endogenous aldehydes: current state of knowledge.
Georgia Persephoni Voulgaridou,Ioannis Anestopoulos,Rodrigo Franco,Mihalis I. Panayiotidis,Mihalis I. Panayiotidis,Aglaia Pappa +5 more
TL;DR: The current knowledge on DNA damage induced by endogenously produced reactive aldehydes in relation to the pathophysiology of human diseases is discussed.
Journal ArticleDOI
Effects of resveratrol on biomarkers of oxidative stress and on the activity of delta aminolevulinic acid dehydratase in liver and kidney of streptozotocin-induced diabetic rats
Roberta Schmatz,Luciane Belmonte Perreira,Naiara Stefanello,Cinthia M. Mazzanti,Roselia Maria Spanevello,Roselia Maria Spanevello,Jessié Martins Gutierres,Margarete Dulce Bagatini,Caroline Curry Martins,Fátima Husein Abdalla,Jonas Daci da Silva Serres,Daniela Zanini,Juliano Marchi Vieira,Andréia Machado Cardoso,Maria Rosa Chitolina Schetinger,Vera Maria Morsch +15 more
TL;DR: It is suggested that resveratrol could have a protector effect against hepatic and renal damage induced by oxidative stress in the diabetic state, which was evidenced by the capacity of this polyphenol to modulate the antioxidant defense and to decrease the lipid peroxidation in these tissues.
Journal ArticleDOI
Role of methylglyoxal in Alzheimer's disease.
TL;DR: Methylglyoxal, a reactive intermediate of cellular metabolism, is the most potent precursor of AGEs and is strictly correlated with an increase of oxidative stress in Alzheimer's disease.
Book ChapterDOI
Mechanisms for countering oxidative stress and damage in retinal pigment epithelium.
TL;DR: The major functions of RPE cells are discussed with an emphasis on the oxidative challenges these cells encounter and the endogenous antioxidant mechanisms employed to neutralize the deleterious effects that such stresses can elicit if left unchecked.
Journal ArticleDOI
Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?
TL;DR: An overview of lipid structure and function, with emphasis on mitochondrial lipids and their potential for therapeutic targeting during ageing and age-related disease is provided.
References
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Journal ArticleDOI
Free Radicals in the Physiological Control of Cell Function
TL;DR: There is growing evidence that aging involves, in addition, progressive changes in free radical-mediated regulatory processes that result in altered gene expression.
Journal ArticleDOI
Aging: A Theory Based on Free Radical and Radiation Chemistry
TL;DR: It seems possible that one factor in aging may be related to deleterious side attacks of free radicals (which are normally produced in the course of cellular metabolism) on cell constituents.
Journal ArticleDOI
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.
TL;DR: This review provides a comprehensive summary on the chemical properties of 4-hydroxyalkenals and malonaldehyde, the mechanisms of their formation and their occurrence in biological systems and methods for their determination, as well as the many types of biological activities described so far.
superoxide production blocks three pathways of hyperglycaemic damage
Takeshi Nishikawa,Diane Edelstein,Xue Liang Du,Sho-ichi Yamagishi,Takeshi Matsumura,Yasufumi Kaneda,Mark A. Yorek,David Beebek,Peter J. Oatesk,Hans-Peter Hammes,Ida Giardino,Michael Brownlee +11 more
TL;DR: This paper showed that hyperglycaemia increases the production of reactive oxygen species inside cultured bovine aortic endothelial cells and that this increase in reactive oxygen can be prevented by an inhibitor of electron transport chain complex II, an uncoupler of oxidative phosphorylation, by uncoupling protein-1 and by manganese superoxide dismutase.
Journal ArticleDOI
The Free Radical Theory of Aging Matures
Kenneth B. Beckman,Bruce N. Ames +1 more
TL;DR: The status of the free radical theory of aging is reviewed, by categorizing the literature in terms of the various types of experiments that have been performed, which include phenomenological measurements of age-associated oxidative stress, interspecies comparisons, dietary restriction, and the ongoing elucidation of the role of active oxygen in biology.