Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons
TLDR
It is reported that lithium causes tau dephosphorylation at the sites recognized by antibodies Tau‐1 and PHF‐1 both in cultured neurons and in vivo in rat brain, consistent with a major role for glycogen synthase kinase‐3 in modifying proline‐directed sites on tau protein within living neurons under physiological conditions.About:
This article is published in FEBS Letters.The article was published on 1997-07-14 and is currently open access. It has received 324 citations till now. The article focuses on the topics: Tau protein & GSK-3.read more
Citations
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Journal ArticleDOI
The renaissance of GSK3.
Philip Cohen,Sheelagh Frame +1 more
TL;DR: Glycogen synthase kinase 3 was initially described as a key enzyme involved in glycogen metabolism, but is now known to regulate a diverse array of cell functions.
Journal ArticleDOI
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
Carol A. Grimes,Richard S. Jope +1 more
TL;DR: GSK3beta has a central role regulating neuronal plasticity, gene expression, and cell survival, and may be a key component of certain psychiatric and neurodegenerative diseases.
Journal ArticleDOI
GSK3 takes centre stage more than 20 years after its discovery.
Sheelagh Frame,Philip Cohen +1 more
TL;DR: These latest findings have generated an enormous amount of interest in the development of drugs that inhibit GSK3 and which may have therapeutic potential for the treatment of diabetes, stroke and Alzheimer's disease.
Journal ArticleDOI
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.
Matthew P. Coghlan,Ainsley A. Culbert,Darren Cross,Stacey L. Corcoran,John W. Yates,Nigel J. Pearce,Olivier Lars SmithKline Beecham Pharmaceu. Rausch,Gregory J. Murphy,Paul S. Carter,Lynne Roxbee Cox,David Mills,Murray J. B. Brown,David Haigh,Robert W. Ward,Smith David Glynn,Kenneth J. Murray,Alastair D. Reith,Julie C. Holder +17 more
TL;DR: SB-216763 and SB-415286 are novel, potent and selective cell permeable inhibitors of GSK-3 and represent valuable pharmacological tools with which the role of G SKS-3 in cellular signalling can be further elucidated.
Journal ArticleDOI
Decreased nuclear β‐catenin, tau hyperphosphorylation and neurodegeneration in GSK‐3β conditional transgenic mice
José J. Lucas,José J. Lucas,Félix Hernández,Félix Hernández,Pilar Gómez-Ramos,María A. Morán,René Hen,Jesús Avila +7 more
TL;DR: It is suggested that conditional transgenic mice overexpressing GSK‐3β in the brain during adulthood while avoiding perinatal lethality due to embryonic transgene expression can be used as an animal model to study the relevance of GSK-3β deregulation to the pathogenesis of Alzheimer's disease.
References
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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
Inge Grundke-Iqbal,Khalid Iqbal,Yunn-Chyn Tung,Maureen Quinlan,Henryk M. Wisniewski,Lester I. Binder +5 more
TL;DR: It is suggested that tau in Alzheimer brain is an abnormally phosphorylated protein component of PHF, the two major locations of paired-helical filaments in Alzheimer disease brain.
Journal ArticleDOI
A synthetic inhibitor of the mitogen-activated protein kinase cascade.
TL;DR: Results indicate that the MAPK pathway is essential for growth and maintenance of the ras-transformed phenotype and PD 098059 is an invaluable tool that will help elucidate the role of theMAPK cascade in a variety of biological settings.
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A molecular mechanism for the effect of lithium on development
Peter S. Klein,Douglas A. Melton +1 more
TL;DR: It is shown that complete inhibition of IMPase has no effect on the morphogenesis of Xenopus embryos and a different hypothesis to explain the broad action of lithium is presented, which suggests that lithium acts through inhibition of glycogen synthase kinase-3 beta (GSK-3beta), which regulates cell fate determination in diverse organisms including Dictyostelium, Drosophila, and Xenopus.
Journal ArticleDOI
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.
TL;DR: Human brain tau and paired helical filament polypeptides co-migrated on sodium dodecyl sulfate-polyacrylamide gels suggest that tau is a major component of Alzheimer paired helicals filaments.
Journal ArticleDOI
Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells
TL;DR: Li+ acts as a specific inhibitor of the GSK-3 family of protein kinases in vitro and in intact cells, and mimics Wingless signalling, revealing a possible molecular mechanism of Li+ action on development and differentiation.
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A molecular mechanism for the effect of lithium on development
Peter S. Klein,Douglas A. Melton +1 more