Journal ArticleDOI
Liver-directed therapies for patients with primary liver cancer and hepatic metastases.
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TLDR
In patients with primary liver cancer, underlying liver disease often prohibits surgical intervention, however, survival advantages have been gained with the application of percutaneous alcohol injection and radiofrequency ablation, and RFA has all aided in prolonging survival.Abstract:
Liver cancer, whether primary or metastatic, is a major cause of death throughout the world. The surgical management of these diseases varies according to the extent of disease and the overall health of the patient. Surgical resection of hepatic disease remains the only chance for cure. However, a large proportion of patients with liver cancer are unable to undergo a complete surgical resection. These patients are often treated with liver-directed therapies. Although not as effective as surgical resection, these approaches can help to improve the survival of patients. In patients with primary liver cancer, underlying liver disease often prohibits surgical intervention. However, survival advantages have been gained with the application of percutaneous alcohol injection and radiofrequency ablation (RFA). In patients with hepatic metastases, the number of metastases is often what prevents surgical resection. In these patients, RFA, cryoablation, and hepatic artery infusional therapy have all aided in prolonging survival. As chemotherapeutic agents improve and targeted therapies are developed, more patients will be able to undergo surgical management of their liver cancer, primary or metastatic.read more
Citations
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Journal ArticleDOI
Thermal ablation by high-intensity-focused ultrasound using a toroid transducer increases the coagulated volume. results of animal experiments
David Melodelima,David Melodelima,W. A. N’Djin,W. A. N’Djin,H. Parmentier,H. Parmentier,Sabrina Chesnais,Sabrina Chesnais,Michel Rivoire,Michel Rivoire,Jean-Yves Chapelon,Jean-Yves Chapelon +11 more
TL;DR: It is reported that a new design of high intensity focused ultrasound transducer can significantly enlarge the coagulated volume over short periods of time and that treatment in the liver can be guided in real-time using an integrated ultrasound imaging probe.
Journal ArticleDOI
Percutaneous Cryoablation for Liver Cancer.
Lizhi Niu,Jialiang Li,Kecheng Xu +2 more
TL;DR: Clinically, primary research has shown that percutaneous cryoablation of liver cancer is relatively safe and efficient, and it can be combined with other methods, such as radiation therapy, chemotherapy, and immunology, to control disease.
Journal ArticleDOI
Finite element modeling of cooled-tip probe radiofrequency ablation processes in liver tissue
TL;DR: Ainite element model of radiofrequency ablation with cooled-tip probe in liver has been developed by employing COMSOL Multiphysics software that describes coupled electric, thermal and sodium chloride solution infiltration flow phenomena taking place during ablation processes.
Journal ArticleDOI
Ultrasound surgery with a toric transducer allows the treatment of large volumes over short periods of time
David Melodelima,William Apoutou N'Djin,H. Parmentier,Sabrina Chesnais,Michel Rivoire,Jean-Yves Chapelon +5 more
TL;DR: In vivo evidence is presented that the coagulated volume obtained from a 40s total exposure in the liver was 8.6±4.8cm3.
Journal ArticleDOI
Transarterial Radioembolization (TARE) Agents beyond 90Y-Microspheres.
Christelle Bouvry,Xavier Palard,Julien Edeline,Valérie Ardisson,Pascal Loyer,Etienne Garin,Nicolas Lepareur +6 more
TL;DR: The aim of this review is to describe TARE alternative technologies currently developed and investigated in clinical trials, with special emphasis on HCC.
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Journal ArticleDOI
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Journal ArticleDOI
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Journal ArticleDOI
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