Liver disease in patients with diabetes mellitus.
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TLDR
It is concluded that functionally significant liver disease is uncommon amongst stabilized diabetic patients.Abstract:
Liver function tests were assessed in 60 unselected out-patient diabetics stabilized on insulin or oral hypoglycaemic agents. Routine liver function tests, particularly plasma concentrations of gamma-glutamyl transpeptidase and alkaline phosphatase were elevated occasionally but rarely to more than twice the upper limit of normal. There was no correlation between measures of diabetic control and results of liver function tests. Twelve (20%) patients had evidence of gall stones, a prevalence above the expected from the community. Fourteen (23%) patients had an abnormally bright liver ultrasound echo pattern, probably indicative of fatty infiltration of the liver. This echo pattern was associated with only a minimal rise in plasma alanine amino transferase and alkaline phosphatase concentrations. It is concluded that functionally significant liver disease is uncommon amongst stabilized diabetic patients.read more
Citations
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Journal ArticleDOI
Nonalcoholic fatty liver disease a feature of the metabolic syndrome
Giulio Marchesini,Mara Brizi,Giampaolo Bianchi,Sara Tomassetti,Elisabetta Bugianesi,Marco Lenzi,Arthur J. McCullough,S. Natale,Gabriele Forlani,Nazario Melchionda +9 more
TL;DR: It is concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity.
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Association of nonalcoholic fatty liver disease with insulin resistance
Giulio Marchesini,Mara Brizi,Antonio Maria Morselli-Labate,Giampaolo Bianchi,Elisabetta Bugianesi,Arthur J. McCullough,Gabriele Forlani,Nazario Melchionda +7 more
TL;DR: Nonalcoholic fatty liver disease is associated with insulin resistance and hyperinsulinemia even in lean subjects with normal glucose tolerance, and genetic factors that reduce insulin sensitivity and increase serum triglyceride levels may be responsible for its development.
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Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection.
TL;DR: Multiple case reports and case reviews of HCC in the setting of NASH support the associations of diabetes and obesity with the risk of H CC, as well as suggest age and advanced fibrosis as significant risks.
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Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications.
TL;DR: Treatments that rescue the liver from lipotoxicity by restoring adipose tissue insulin sensitivity or preventing activation of inflammatory pathways and oxidative stress hold promise in the treatment of NAFLD, although their long-term safety and efficacy remain to be established.
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Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma
Manal M. Hassan,Steven A. Curley,Donghui Li,Ahmed Kaseb,Marta L. Davila,Eddie K. Abdalla,Milind Javle,Dalia M. Moghazy,Richard D. Lozano,James L. Abbruzzese,Jean Nicolas Vauthey +10 more
TL;DR: The association between HCC risk and diabetes duration and type of diabetes treatment and whether some diabetes medications reduced the risk of HCC development was determined.
References
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In vitro synthesis of hemoglobin AIc
TL;DR: The present study was undertaken to determine the structure and synthetic pathway of HbAfc, and indicated the bond to be a Schiff base which, however, proved stable even at pH 4.0.
Book ChapterDOI
Gamma-glutamyl transpeptidase.
TL;DR: This chapter discusses the measurement of the serum γ-glutamyl transpeptidase (GGTP) in the clinical laboratory and its application to diagnosis.
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Lynn J. Bennion,Scott M. Grundy +1 more
TL;DR: Bile lipid composition was more favorable to cholesterol precipitation and gallstone formation during insulin treatment than in the untreated diabetic state, and the increased plasma lipid levels and total cholesterol synthesis during hyperglycemia may contribute to the acceleration of atherosclerosis in diabetes mellitus.
Journal ArticleDOI
The accuracy of ultrasound in the detection of fatty infiltration of the liver
TL;DR: The experience on the accuracy with which ultrasound will detect a fatty liver is reported on the basis of the liver ultrasound images in patients known to have either histologically normal livers or livers with fatty infiltration.
Journal ArticleDOI
Ultrasound in the detection of chronic liver disease (the "bright liver").
TL;DR: A small pilot study is undertaken based on the observation of a bright liver echo pattern in relatively mild cases of cirrhosis and in other chronic liver diseases to assess its clinical significance.
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