Journal ArticleDOI
Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes.
Donna H. Ryan,Mark A. Espeland,Gary D. Foster,Steven M. Haffner,Van S. Hubbard,Karen C. Johnson,Steven E. Kahn,William C. Knowler,Susan Z. Yanovski +8 more
Reads0
Chats0
TLDR
The Look AHEAD clinical trial is to assess the long-term effects of an intensive weight loss program delivered over 4 years in overweight and obese individuals with type 2 diabetes and is designed to provide a 0.90 probability of detecting an 18% difference in major CVD event rates between the two groups.About:
This article is published in Controlled Clinical Trials.The article was published on 2003-10-01. It has received 681 citations till now. The article focuses on the topics: Weight loss & Overweight.read more
Citations
More filters
Journal ArticleDOI
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes.
Rena R. Wing,Paula Bolin,Frederick L. Brancati,George A. Bray,Jeanne M. Clark,Mace Coday,Richard S. Crow,Jeffrey M. Curtis,Caitlin Egan,Mark A. Espeland,Mary Evans,John P. Foreyt,Siran Ghazarian,Edward W. Gregg,Barbara Harrison,Helen P. Hazuda,James O. Hill,Edward S. Horton,S. Van Hubbard,John M. Jakicic,Robert W. Jeffery,Karen C. Johnson,Steven E. Kahn,Abbas E. Kitabchi,William C. Knowler,Cora E. Lewis,Barbara J. Maschak-Carey,Maria G. Montez,Anne Murillo,David M. Nathan,Jennifer Patricio,Anne L. Peters,Xavier Pi-Sunyer,Henry J. Pownall,David M. Reboussin,Judith G. Regensteiner,Amy D. Rickman,Donna H. Ryan,Monika M. Safford,Thomas A. Wadden,Lynne E. Wagenknecht,Delia Smith West,David F. Williamson,Susan Z. Yanovski +43 more
TL;DR: An intensive lifestyle intervention focusing on weight loss did not reduce the rate of cardiovascular events in overweight or obese adults with type 2 diabetes.
Journal ArticleDOI
Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association.
John P. Bantle,Judith Wylie-Rosett,Ann L. Albright,Caroline M. Apovian,Nathaniel G. Clark,Marion J. Franz,Byron J. Hoogwerf,Alice H. Lichtenstein,Elizabeth J. Mayer-Davis,Arshag D. Mooradian,Madelyn L. Wheeler +10 more
TL;DR: This position statement provides evidence-based recommendations and interventions for diabetes MNT and focuses on key references published since the year 2000, and uses grading according to the level of evidence available.
Journal ArticleDOI
Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes: One-Year Results of the Look AHEAD Trial
Mark A. Espeland,Xavier Pi-Sunyer,George L. Blackburn,Frederick L. Brancati,George A. Bray,Renee Bright,Jeanne M. Clark,Jeffrey M. Curtis,John P. Foreyt,Kathryn Graves,Steven M. Haffner,Barbara Harrison,James O. Hill,Edward S. Horton,John M. Jakicic,Robert W. Jeffery,Karen C. Johnson,Steven E. Kahn,David E. Kelley,Abbas E. Kitabchi,William C. Knowler,Cora E. Lewis,Barbara J. Maschak-Carey,Brenda Montgomery,David M. Nathan,Jennifer Patricio,Anne L. Peters,J. Bruce Redmon,Rebecca S. Reeves,Donna H. Ryan,Monika M. Safford,Brent Van Dorsten,Thomas A. Wadden,Lynne E. Wagenknecht,Jacqueline Wesche-Thobaben,Rena R. Wing,Susan Z. Yanovski +36 more
TL;DR: At 1 year, ILI resulted in clinically significant weight loss in people with type 2 diabetes and was associated with improved diabetes control and CVD risk factors and reduced medicine use in ILI versus DSE.
Journal ArticleDOI
Benefits of Modest Weight Loss in Improving Cardiovascular Risk Factors in Overweight and Obese Individuals With Type 2 Diabetes
Rena R. Wing,Wei Lang,Thomas A. Wadden,Monika M. Safford,William C. Knowler,Alain G. Bertoni,James O. Hill,Frederick L. Brancati,Anne L. Peters,Lynne E. Wagenknecht +9 more
TL;DR: Modest weight losses of 5 to <10% were associated with significant improvements in CVD risk factors at 1 year, but larger weight losses had greater benefits.
Journal ArticleDOI
Management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes.
David M. Nathan,John B. Buse,Mayer B. Davidson,Robert J. Heine,Rury R. Holman,Robert S. Sherwin,Bernard Zinman +6 more
TL;DR: The development of new classes of blood glucose–lowering medications to supplement the older therapies, such as lifestyle-directed interventions, insulin, sulfonylureas, and metformin, has increased the treatment options for type 2 diabetes.
References
More filters
Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal ArticleDOI
An inventory for measuring depression
TL;DR: The difficulties inherent in obtaining consistent and adequate diagnoses for the purposes of research and therapy have been pointed out and a wide variety of psychiatric rating scales have been developed.
Book ChapterDOI
Regression Models and Life-Tables
TL;DR: The analysis of censored failure times is considered in this paper, where the hazard function is taken to be a function of the explanatory variables and unknown regression coefficients multiplied by an arbitrary and unknown function of time.
Journal ArticleDOI
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
William C. Knowler,Elizabeth Barrett-Connor,Sarah E. Fowler,Richard F. Hamman,John M. Lachin,Elizabeth A. Walker,David M. Nathan +6 more
TL;DR: In this paper, the authors compared a lifestyle intervention with metformin to prevent or delay the development of Type 2 diabetes in nondiabetic individuals. And they found that the lifestyle intervention was significantly more effective than the medication.
Book
ACSM's guidelines for exercise testing and prescription
TL;DR: In this paper, the authors discuss the benefits and risks associated with physical activity and propose a general principles of exercise prescription for healthy populations with special consideration and environmental consideration, as well as a prescription for patients with chronic diseases and health conditions.
Related Papers (5)
Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes: One-Year Results of the Look AHEAD Trial
Mark A. Espeland,Xavier Pi-Sunyer,George L. Blackburn,Frederick L. Brancati,George A. Bray,Renee Bright,Jeanne M. Clark,Jeffrey M. Curtis,John P. Foreyt,Kathryn Graves,Steven M. Haffner,Barbara Harrison,James O. Hill,Edward S. Horton,John M. Jakicic,Robert W. Jeffery,Karen C. Johnson,Steven E. Kahn,David E. Kelley,Abbas E. Kitabchi,William C. Knowler,Cora E. Lewis,Barbara J. Maschak-Carey,Brenda Montgomery,David M. Nathan,Jennifer Patricio,Anne L. Peters,J. Bruce Redmon,Rebecca S. Reeves,Donna H. Ryan,Monika M. Safford,Brent Van Dorsten,Thomas A. Wadden,Lynne E. Wagenknecht,Jacqueline Wesche-Thobaben,Rena R. Wing,Susan Z. Yanovski +36 more
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes.
Rena R. Wing,Paula Bolin,Frederick L. Brancati,George A. Bray,Jeanne M. Clark,Mace Coday,Richard S. Crow,Jeffrey M. Curtis,Caitlin Egan,Mark A. Espeland,Mary Evans,John P. Foreyt,Siran Ghazarian,Edward W. Gregg,Barbara Harrison,Helen P. Hazuda,James O. Hill,Edward S. Horton,S. Van Hubbard,John M. Jakicic,Robert W. Jeffery,Karen C. Johnson,Steven E. Kahn,Abbas E. Kitabchi,William C. Knowler,Cora E. Lewis,Barbara J. Maschak-Carey,Maria G. Montez,Anne Murillo,David M. Nathan,Jennifer Patricio,Anne L. Peters,Xavier Pi-Sunyer,Henry J. Pownall,David M. Reboussin,Judith G. Regensteiner,Amy D. Rickman,Donna H. Ryan,Monika M. Safford,Thomas A. Wadden,Lynne E. Wagenknecht,Delia Smith West,David F. Williamson,Susan Z. Yanovski +43 more