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Valle Tt
Researcher at Hammersmith Hospital
Publications - 19
Citations - 14983
Valle Tt is an academic researcher from Hammersmith Hospital. The author has contributed to research in topics: Type 2 diabetes & Impaired glucose tolerance. The author has an hindex of 12, co-authored 19 publications receiving 14523 citations.
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Journal ArticleDOI
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.
Jaakko Tuomilehto,Jon Lindstrom,Johan G. Eriksson,Valle Tt,Helena Hämäläinen,Pirjo Ilanne-Parikka,Keinänen-Kiukaanniemi S,Mauri Laakso,Anne Louheranta,Rastas M,Salminen,Matti Uusitupa +11 more
TL;DR: Type 2 diabetes can be prevented by changes in the lifestyles of high-risk subjects by means of individualized counseling aimed at reducing weight, total intake of fat, and intake of saturated fat and increasing intake of fiber and physical activity.
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Elizabeth K. Speliotes,Cristen J. Willer,Sonja I. Berndt,Keri L. Monda,Gudmar Thorleifsson,Anne U. Jackson,H Lango Allen,Cecilia M. Lindgren,Jian'an Luan,Reedik Mägi,Joshua C. Randall,Sailaja Vedantam,Thomas W. Winkler,Lu Qi,Tsegaselassie Workalemahu,Iris M. Heid,Valgerdur Steinthorsdottir,Heather M. Stringham,Michael N. Weedon,Eleanor Wheeler,Andrew R. Wood,Teresa Ferreira,Robert J. Weyant,Ayellet V. Segrè,K. Estrada,Liming Liang,James Nemesh,Ju-Hyun Park,Stefan Gustafsson,Tuomas O. Kilpeläinen,Jian Yang,Nabila Bouatia-Naji,Tõnu Esko,Mary F. Feitosa,Zoltán Kutalik,Massimo Mangino,Soumya Raychaudhuri,André Scherag,Albert V. Smith,Ryan P. Welch,Jing Hua Zhao,Katja K.H. Aben,Devin Absher,Najaf Amin,Anna L. Dixon,Eva Fisher,Nicole L. Glazer,Michael E. Goddard,Nancy L. Heard-Costa,Volker Hoesel,Jouke-Jan Hottenga,Åsa Johansson,Toby Johnson,Shamika Ketkar,Claudia Lamina,Shengxu Li,MF Moffatt,Richard H. Myers,Narisu Narisu,John R. B. Perry,Maire Peters,Michael Preuss,Samuli Ripatti,Fernando Rivadeneira,Camilla H. Sandholt,Laura J. Scott,Nicholas J. Timpson,Jonathan Tyrer,S. van Wingerden,Richard M. Watanabe,Charles L. White,Fredrik Wiklund,Cristina Barlassina,Daniel I. Chasman,Mark E. Cooper,John-Olov Jansson,Robert W. Lawrence,Niina Pellikka,Inga Prokopenko,Jianxin Shi,Elisabeth Thiering,Helene Alavere,Maria Teresa Sciarrone Alibrandi,Peter Almgren,Andreas Arnold,Thor Aspelund,Larry D. Atwood,Beverley Balkau,Anthony J. Balmforth,Amanda J. Bennett,Yoav Ben-Shlomo,Richard N. Bergman,Sven Bergmann,Heike Biebermann,Alexandra I. F. Blakemore,Tanja Boes,Lori L. Bonnycastle,Stefan R. Bornstein,Michael Brown,Thomas A. Buchanan,Fabio Busonero,Harry Campbell,Francesco P. Cappuccio,Christine Cavalcanti-Proença,Y. D. Chen,C. M. Chen,Peter S. Chines,Robert Clarke,Lachlan J. M. Coin,John M. C. Connell,Ian N.M. Day,M. den Heijer,Jubao Duan,Shah Ebrahim,Paul Elliott,Roberto Elosua,G. Eiriksdottir,Mike Erdos,Johan G. Eriksson,Maurizio Facheris,Stephan B. Felix,Pamela Fischer-Posovszky,Aaron R. Folsom,Nele Friedrich,Nelson B. Freimer,Mao Fu,Stéphane Gaget,Pablo V. Gejman,Eco J. C. de Geus,Christian Gieger,Anette P. Gjesing,Anuj Goel,Philippe Goyette,Harald Grallert,Jürgen Grässler,Danielle M. Greenawalt,C J Groves,Vilmundur Gudnason,Candace Guiducci,A.-L. Hartikainen,N Hassanali,Alistair S. Hall,Aki S. Havulinna,Caroline Hayward,Andrew C. Heath,Christian Hengstenberg,Andrew A. Hicks,Anke Hinney,Albert Hofman,G. Homuth,Jennie Hui,Wilmar Igl,Carlos Iribarren,Bo Isomaa,Kevin B. Jacobs,Ivonne Jarick,Elizabeth S. Jewell,Ulrich John,Torben Jørgensen,P. Jousilahti,A. Jula,Marika Kaakinen,Eero Kajantie,Lee M. Kaplan,Sekar Kathiresan,Johannes Kettunen,Leena Kinnunen,Joshua W. Knowles,Ivana Kolcic,Inke R. König,Seppo Koskinen,Peter Kovacs,Johanna Kuusisto,Peter Kraft,Kirsti Kvaløy,Jaana Laitinen,Olivier Lantieri,Chiara Lanzani,Lenore J. Launer,Cécile Lecoeur,Terho Lehtimäki,Guillaume Lettre,Jianjun Liu,Marja-Liisa Lokki,Mattias Lorentzon,Robert Luben,Barbara Ludwig,Paolo Manunta,Diana Marek,Michel Marre,Nicholas G. Martin,Wendy L. McArdle,Alun D. McCarthy,Barbara McKnight,Thomas Meitinger,Olle Melander,David Meyre,Kristian Midthjell,Grant W. Montgomery,M. A. Morken,Andrew P. Morris,Rosanda Mulić,Julius S. Ngwa,Mari Nelis,Matt Neville,Dale R. Nyholt,Christopher J. O'Donnell,Stephen O'Rahilly,Ken K. Ong,Ben A. Oostra,Guillaume Paré,Alex N. Parker,Markus Perola,Irene Pichler,Kirsi H. Pietiläinen,Carl Platou,Ozren Polasek,A Pouta,Suzanne Rafelt,Olli T. Raitakari,Nigel W. Rayner,Martin Ridderstråle,Winfried Rief,Aimo Ruokonen,Neil R. Robertson,Peter Rzehak,Veikko Salomaa,Alan R. Sanders,Manjinder S. Sandhu,Serena Sanna,Jouko Saramies,Markku J. Savolainen,S. Scherag,Sabine Schipf,Stefan Schreiber,Heribert Schunkert,Kaisa Silander,Juha Sinisalo,David S. Siscovick,J.H. Smit,Nicole Soranzo,Ulla Sovio,J. Stephens,Ida Surakka,Amy J. Swift,M. L. Tammesoo,Jean-Claude Tardif,Maris Teder-Laving,Tanya M. Teslovich,John R. Thompson,Brian Thomson,A Tönjes,Tiinamaija Tuomi,J.B. van Meurs,G.J.B. van Ommen,Vincent Vatin,Jorma Viikari,Sophie Visvikis-Siest,Veronique Vitart,Charlotte Vogel,Benjamin F. Voight,Lindsay L. Waite,Henri Wallaschofski,G B Walters,E. Widen,Susanna Wiegand,Sarah H. Wild,Gonneke Willemsen,Daniel R. Witte,Jacqueline C. M. Witteman,Jianfeng Xu,Qunyuan Zhang,Lina Zgaga,Andreas Ziegler,P. Zitting,John Beilby,I S Farooqi,Johannes Hebebrand,Heikki V. Huikuri,Alan L. James,Mika Kähönen,Douglas F. Levinson,Fabio Macciardi,Markku S. Nieminen,Claes Ohlsson,Lyle J. Palmer,Paul M. Ridker,Michael Stumvoll,Jacques S. Beckmann,H. Boeing,Eric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Stephen J. Chanock,Francis S. Collins,L. A. Cupples,George Davey Smith,Jeanette Erdmann,Philippe Froguel,Henrik Grönberg,Ulf Gyllensten,Per Hall,Torben Hansen,Tamara B. Harris,Andrew T. Hattersley,Richard B. Hayes,Joachim Heinrich,Frank B. Hu,Kristian Hveem,Thomas Illig,Marjo-Riitta Järvelin,Jaakko Kaprio,Fredrik Karpe,Kay-Tee Khaw,Lambertus A. Kiemeney,Heiko Krude,Markku Laakso,Debbie A Lawlor,Andres Metspalu,Patricia B. Munroe,Willem H. Ouwehand,Oluf Pedersen,Brenda W.J.H. Penninx,Annette Peters,Peter P. Pramstaller,Thomas Quertermous,Thomas Reinehr,A. Rissanen,Igor Rudan,Nilesh J. Samani,Peter Schwarz,Alan R. Shuldiner,Tim D. Spector,Jaakko Tuomilehto,Manuela Uda,André G. Uitterlinden,Valle Tt,Martin Wabitsch,G. Waeber,Nicholas J. Wareham,Hugh Watkins,James F. Wilson,Alan F. Wright,M. C. Zillikens,Nilanjan Chatterjee,Steven A. McCarroll,Shaun Purcell,Eric E. Schadt,Peter M. Visscher,Themistocles L. Assimes,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Leif Groop,Talin Haritunians,David J. Hunter,Robert C. Kaplan,Karen L. Mohlke,Jeffrey R. O'Connell,Leena Peltonen,David Schlessinger,David P. Strachan,C M van Duijn,H. E. Wichmann,Timothy M. Frayling,Unnur Thorsteinsdottir,Gonçalo R. Abecasis,Inês Barroso,Michael Boehnke,Kari Stefansson,Kari E. North,Mark I. McCarthy,Joel N. Hirschhorn,Erik Ingelsson,Ruth J. F. Loos +374 more
TL;DR: 18 new loci associated with body mass index are identified, one of which includes a copy number variant near GPRC5B, and genes in other newly associated loci may provide new insights into human body weight regulation.
Journal Article
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (vol 42, pg 105, 2010)
Josée Dupuis,Claudia Langenberg,Inga Prokopenko,Richa Saxena,Nicole Soranzo,Anne U. Jackson,Eleanor Wheeler,Nicole L. Glazer,Nabila Bouatia-Naji,Anna L. Gloyn,C M Lindgren,Reedik Mägi,Andrew P. Morris,Joshua C. Randall,Toby Johnson,Peter J. Elliott,D Rybin,Gudmar Thorleifsson,Steinthorsdottir,Peter Henneman,H Grallert,Abbas Dehghan,J-J Hottenga,Christopher S. Franklin,Pau Navarro,KJ Song,Anuj Goel,Jrb Perry,Josephine M. Egan,Taina K. Lajunen,Niels Grarup,Thomas Sparsø,Alex S. F. Doney,B F Voight,Heather M. Stringham,Man Li,Stavroula Kanoni,Peter Shrader,Christine Cavalcanti-Proença,Meena Kumari,Lu Qi,N J Timpson,Christian Gieger,Carina Zabena,Ghislain Rocheleau,Erik Ingelsson,Ping An,Jeffery R. O'Connell,Jian'an Luan,Amanda F. Elliott,Steve McCarroll,Felicity Payne,Rosa Maria Roccasecca,François Pattou,Praveen Sethupathy,Kristin G. Ardlie,Yavuz Ariyurek,B. Balkau,Philip J. Barter,John Beilby,Yoav Ben-Shlomo,Rafn Benediktsson,Amanda J. Bennett,Sven Bergmann,Murielle Bochud,Eric Boerwinkle,Amélie Bonnefond,Lori L. Bonnycastle,Knut Borch-Johnsen,Yvonne Böttcher,Eric J. Brunner,Suzannah Bumpstead,Guillaume Charpentier,Ydi Chen,Peter S. Chines,Robert Clarke,Ljm Coin,Mark E. Cooper,Marilyn C. Cornelis,Gabriel Crawford,Laura Crisponi,Inm Day,Ejc de Geus,Jérôme Delplanque,Christian Dina,Erdos,A C Fedson,Antje Fischer-Rosinsky,Nita G. Forouhi,Caroline S. Fox,Rune R. Frants,MariaGrazia Franzosi,Pilar Galan,Mark O. Goodarzi,J. Graessler,C J Groves,Scott M. Grundy,R. Gwilliam,Ulf Gyllensten,Samy Hadjadj,Göran Hallmans,Naomi Hammond,Xijing Han,A.-L. Hartikainen,N Hassanali,Caroline Hayward,Simon C. Heath,Serge Hercberg,Christian Herder,Andrew A. Hicks,Hillman,Aroon D. Hingorani,A. Hofman,Jennie Hui,Joseph Hung,Bo Isomaa,Prv Johnson,Torben Jørgensen,A. Jula,Marika Kaakinen,J Kaprio,Y A Kesaniemi,Mika Kivimäki,Beatrice Knight,Seppo Koskinen,Peter Kovacs,Kirsten Ohm Kyvik,G. M. Lathrop,Debbie A Lawlor,O Le Bacquer,C. Lecoeur,Yun Li,Lyssenko,Robert W. Mahley,Massimo Mangino,Alisa K. Manning,María Teresa Martínez-Larrad,Jarred B. McAteer,Laura J. McCulloch,Ruth McPherson,Christine Meisinger,David Melzer,David Meyre,Braxton D. Mitchell,M. A. Morken,Sutapa Mukherjee,Silvia Naitza,Narisu Narisu,Matt J. Neville,Ben A. Oostra,Marco Orrù,Ruth E. Pakyz,Cna Palmer,Giuseppe Paolisso,Cristian Pattaro,Daniel S. Pearson,J F Peden,Nancy L. Pedersen,M. Perola,Afh Pfeiffer,Irene Pichler,Ozren Polasek,Danielle Posthuma,Simon C. Potter,A Pouta,M. A. Province,Bruce M. Psaty,Wolfgang Rathmann,N W Rayner,Kenneth Rice,S. Ripatti,Fernando Rivadeneira,Michael Roden,Olov Rolandsson,A. Sandbaek,M. S. Sandhu,Serena Sanna,Avan Aihie Sayer,Paul Scheet,Laura J. Scott,Udo Seedorf,Stephen J. Sharp,B M Shields,G Sigurosson,Ejg Sijbrands,Angela Silveira,Laila Simpson,AB Singleton,Nicholas L. Smith,Ulla Sovio,Amy J. Swift,Holly E. Syddall,Ann-Christine Syvänen,Toshiko Tanaka,Barbara Thorand,Jean Tichet,A Tönjes,Tiinamaija Tuomi,A.G. Uitterlinden,K W van Dijk,M. van Hoek,Dhiraj Varma,Sophie Visvikis-Siest,Vitart,Nicole Vogelzangs,G. Waeber,P J Wagner,Andrew Walley,G B Walters,Kim L. Ward,Hugh Watkins,Michael N. Weedon,Sarah H. Wild,Gonneke Willemsen,Jcm Witteman,Jwg Yarnell,E Zeggini,Diana Zelenika,Björn Zethelius,Guangju Zhai,Jing Hua Zhao,M. C. Zillikens,Ingrid B. Borecki,Rjf Loos,Pierre Meneton,Pke Magnusson,David M. Nathan,Gordon H. Williams,Andrew T. Hattersley,Kaisa Silander,Salomaa,George Davey Smith,Bornstein,Peter Schwarz,Jochen Spranger,F Karpe,A. R. Shuldiner,Cyrus Cooper,George Dedoussis,Manuel Serrano-Ríos,Andrew D. Morris,Lars Lind,Lyle J. Palmer,Frank B. Hu,Paul W. Franks,S Ebrahim,Michael Marmot,Whl Kao,James S. Pankow,Mike Sampson,Johanna Kuusisto,Markku Laakso,T. Hansen,Oluf Pedersen,Peter P. Pramstaller,Heinz Erich Wichmann,Thomas Illig,Igor Rudan,Alan F. Wright,Michael Stumvoll,Harry Campbell,James F. Wilson,Anders Hamsten,Richard N. Bergman,Thomas A. Buchanan,F. S. Collins,Karen L. Mohlke,J. Tuomilehto,Valle Tt,David Altshuler,Jerome I. Rotter,David S. Siscovick,Bwjh Penninx,D.I. Boomsma,Panagiotis Deloukas,Tim D. Spector,Timothy M. Frayling,L Ferrucci,Augustine Kong,Unnur Thorsteinsdottir,Kari Stefansson,C M van Duijn,Y S Aulchenko,Anyuan Cao,Angelo Scuteri,David Schlessinger,Manuela Uda,Aimo Ruokonen,Jarvelin,Dawn M. Waterworth,Peter Vollenweider,Leena Peltonen,Mooser,Gonçalo R. Abecasis,Nicholas J. Wareham,Robert Sladek,Philippe Froguel,Richard M. Watanabe,James B. Meigs,Leif Groop,Michael Boehnke,Mark I. McCarthy,Jose C. Florez,Ines Barroso Magic Investigators +303 more
Journal ArticleDOI
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Richa Saxena,Richa Saxena,Claudia Langenberg,Toshiko Tanaka,Toshiko Tanaka,James S. Pankow,Peter Vollenweider,Valeriya Lyssenko,Nabila Bouatia-Naji,Josée Dupuis,Anne U. Jackson,W. H. Linda Kao,Man Li,Nicole L. Glazer,Alisa K. Manning,Jian Anluan,Heather M. Stringham,Inga Prokopenko,Toby Johnson,Niels Grarup,Trine Welløv Boesgaard,Cécile Lecoeur,Peter Shrader,Jeffrey R. O'Connell,Erik Ingelsson,Erik Ingelsson,David Couper,Kenneth Rice,Kijoung Song,Camilla H. Andreasen,Christian Dina,Anna Köttgen,Olivier Le Bacquer,François Pattou,Jalal Taneera,Valgerdur Steinthorsdottir,Denis Rybin,Kristin Ardlie,Mike Sampson,Lu Qi,Mandy van Hoek,Michael N. Weedon,Yurii S. Aulchenko,Benjamin F. Voight,Benjamin F. Voight,Harald Grallert,Beverley Balkau,Richard N. Bergman,Suzette J. Bielinski,Amélie Bonnefond,Lori L. Bonnycastle,Knut Borch-Johnsen,Yvonne Böttcher,Eric J. Brunner,Thomas A. Buchanan,Suzannah Bumpstead,Christine Cavalcanti-Proença,Guillaume Charpentier,Yii-Der Ida Chen,Peter S. Chines,Francis S. Collins,Marilyn C. Cornelis,Gabriel Crawford,Jérôme Delplanque,Alex S. F. Doney,Josephine M. Egan,Michael R. Erdos,Mathieu Firmann,Nita G. Forouhi,Caroline S. Fox,Caroline S. Fox,Mark O. Goodarzi,J. Graessler,Aroon D. Hingorani,Bo Isomaa,Torben Jørgensen,Mika Kivimäki,Peter Kovacs,Knut Krohn,Meena Kumari,Torsten Lauritzen,Claire Levy-Marchal,Vladimir Mayor,Jarred B. McAteer,Jarred B. McAteer,David Meyre,Braxton D. Mitchell,Karen L. Mohlke,Mario A. Morken,Narisu Narisu,Colin N. Apalmer,Ruth E. Pakyz,Laura Pascoe,Felicity Payne,Daniel S. Pearson,Wolfgang Rathmann,Annelli Sandbæk,Avan Aihie Sayer,Laura J. Scott,Stephen J. Sharp,Eric J.G. Sijbrands,Andrew B. Singleton,David S. Siscovick,Nicholas L. Smith,Nicholas L. Smith,Thomas Sparsø,Amy J. Swift,Holly E. Syddall,Gudmar Thorleifsson,Anke Tönjes,Anke Tönjes,Tiinamaija Tuomi,Jaakko Tuomilehto,Valle Tt,Gerard Waeber,Andrew Walley,Dawn M. Waterworth,Eleftheria Zeggini,Jing Hua Zhao,Thomas Illig,H.-Erich Wichmann,H.-Erich Wichmann,James F. Wilson,Cornelia M. van Duijn,Frank B. Hu,Frank B. Hu,Andrew D. Morris,Timothy M. Frayling,Timothy M. Frayling,Andrew T. Hattersley,Andrew T. Hattersley,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Peter M. Nilsson,Ann-Christine Syvänen,Alan R. Shuldiner,Alan R. Shuldiner,Mark Walker,Stefan R. Bornstein,Peter Schwarz,Gordon H. Williams,David M. Nathan,Johanna Kuusisto,Markku Laakso,Cyrus Cooper,Michael Marmot,Luigi Ferrucci,Vincent Mooser,Michael Stumvoll,Ruth J. F. Loos,David Altshuler,David Altshuler,Bruce M. Psaty,Jerome I. Rotter,Eric Boerwinkle,Torben Hansen,Torben Hansen,Oluf Pedersen,Oluf Pedersen,Jose C. Florez,Jose C. Florez,Mark I. McCarthy,Mark I. McCarthy,Michael Boehnke,Inês Barroso,Robert Sladek,Philippe Froguel,Philippe Froguel,James B. Meigs,Leif Groop,Nicholas J. Wareham,Richard M. Watanabe +173 more
TL;DR: A meta-analysis of nine genome-wide association studies and a follow-up of 29 independent loci found three newly implicated loci to be associated with type 2 diabetes: GIPR, ADCY5 and VPS13C.
Journal ArticleDOI
Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: The Finnish Diabetes Prevention Study.
Salopuro T,Leena Pulkkinen,Jon Lindstrom,Johan G. Eriksson,Valle Tt,Helena Hämäläinen,Pirjo Ilanne-Parikka,Sirkka Keinänen-Kiukaanniemi,J. Tuomilehto,Markku Laakso,M. I. J. Uusitupa +10 more
TL;DR: Two polymorphisms in the extracellular domain of the leptin receptor predicted the conversion to type 2 diabetes in high-risk individuals with IGT and the Del/Ins polymorphism in the 3′UTR of LEPR was associated with body weight.