Journal ArticleDOI
Low-Dose Amiodarone for Maintenance of Sinus Rhythm After Cardioversion of Atrial Fibrillation or Flutter
A. T. M. Gosselink,Harry J.G.M. Crijns,I. C. Van Gelder,H. Hillige,Ans C.P. Wiesfeld,Kong I. Lie +5 more
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TLDR
Low-dose amiodarone is effective for maintaining sinus rhythm in patients with difficult to treat chronic atrial fibrillation or flutter and is associated with a low incidence of serious side effects.Abstract:
Objective. —To study efficacy and safety of low-dose amiodarone for maintenance of sinus rhythm after electrical cardioversion of atrial fibrillation or flutter. Design. —Nonrandomized trial; mean duration of follow-up, 20.7 months. Setting. —Referral center; institutional practice; both hospitalized and ambulatory care. Patients. —Eighty-nine consecutive patients having chronic atrial fibrillation or flutter and eligible for cardioversion. Patients had failed previous treatment aimed at maintaining sinus rhythm. During follow-up one patient was withdrawn because of side effects; all patients were available for follow-up. Intervention. —Before cardioversion, patients received 600 mg of amiodarone daily during a 4-week loading period. After conversion, the daily maintenance dose was 204±66 mg (mean±SD). Main Outcome Measures. —Arrhythmia recurrence and adverse effects causing drug discontinuation. Results. —During loading, 15 patients (16%) converted, and after electrical cardioconversion, 90% of all patients had sinus rhythm. Actuarially, 53% of these patients were still in sinus rhythm after 3 years. In patients with compromised left ventricular function, 93% maintained sinus rhythm after 6 months. One patient died due to congestive heart failure. Intolerable side effects occurred in one patient. No proarrhythmia was observed. Logistic regression analysis revealed that amiodarone was ineffective in patients with mitral stenosis or chronic arrhythmia. Conclusions. —Low-dose amiodarone is effective for maintaining sinus rhythm in patients with difficult to treat chronic atrial fibrillation or flutter and is associated with a low incidence of serious side effects. (JAMA. 1992;267:3289-3293)read more
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2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS).
Gerhard Hindricks,Tatjana S. Potpara,Nikolaos Dagres,Elena Arbelo,Jeroen J. Bax,Carina Blomström-Lundqvist,Giuseppe Boriani,Manuel Castellá,Gheorghe Andrei Dan,Polychronis Dilaveris,Laurent Fauchier,Gerasimos Filippatos,Jonathan M. Kalman,Jonathan M. Kalman,Mark La Meir,Deirdre A. Lane,Jean-Pierre Lebeau,Maddalena Lettino,G. Y. H. Lip,Fausto J. Pinto,G. Neil Thomas,Marco Valgimigli,Isabelle C. Van Gelder,Isabelle C. Van Gelder,Bart P. Van Putte,Caroline L Watkins +25 more
TL;DR: The content of these European Society of Cardiology (ESC) Guidelines has been published for personal and educational use only and no commercial use is authorized.
Journal ArticleDOI
ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society
Valentin Fuster,Lars Rydén,David S. Cannom,Harry J.G.M. Crijns,Anne B. Curtis,Kenneth A. Ellenbogen,Jonathan L. Halperin,Jean-Yves Le Heuzey,G. Neal Kay,James E. Lowe,S. Bertil Olsson,Eric N. Prystowsky,Juan Tamargo,Samuel Wann,Sidney C. Smith,Alice K. Jacobs,Cynthia D. Adams,Jeffery L. Anderson,Elliott M. Antman,Sharon A. Hunt,Rick A. Nishimura,Joseph P. Ornato,Richard L. Page,Barbara Riegel,Silvia G. Priori,Jean Jacques Blanc,Andrzej Budaj,A. John Camm,Veronica Dean,Jaap W. Deckers,Catherine Despres,Kenneth Dickstein,John Lekakis,Keith McGregor,Marco Metra,João Morais,Ady Osterspey,José Luis Zamorano +37 more
TL;DR: Sidney C. Smith, Jr., MD, FACC, FAHA, FESC, Chair; Alice K. Jacobs, MD, FAC, FAH, Vice-Chair; Cynthia D. Adams, MSN, APRN-BC, FAGA; Jeffery L. Anderson, MD.
Journal ArticleDOI
ACC/AHA/ESC Guidelines for the Management of Patients With Atrial Fibrillation: Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to Develop Guidelines for the Management of Patients With Atrial Fibrillation) Developed in Collaboration With the North American Society of Pacing and Electrophysiology
Valentin Fuster,Lars Rydén,Richard W. Asinger,David S. Cannom,Harry J.G.M. Crijns,Robert L. Frye,Jonathan L. Halperin,G. Neal Kay,Werner Klein,Samuel Lévy,Robert L. McNamara,Eric N. Prystowsky,L. Samuel Wann,D. George Wyse,Raymond J. Gibbons,Elliott M. Antman,Joseph S. Alpert,David P. Faxon,Gabriel Gregoratos,Loren F. Hiratzka,Alice K. Jacobs,Richard O. Russell,Sidney C. Smith,Angeles Alonso-Garcia,Carina Blomström-Lundqvist,Guy De Backer,Marcus Flather,Jaromír Hradec,Ali Oto,A. Parkhomenko,Sigmund Silber,Adam Torbicki +31 more
TL;DR: New guidelines for management of supraventricular tachyarrhythmia characterized by uncoordinated atrial activation with consequent deterioration of atrial mechanical function are published.
Journal ArticleDOI
ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation)
Valentin Fuster,Lars Rydén,David S. Cannom,Harry J.G.M. Crijns,Anne B. Curtis,Kenneth A. Ellenbogen,Jonathan L. Halperin,Jean-Yves Le Heuzey,G. Neal Kay,James E. Lowe,S. Bertil Olsson,Eric N. Prystowsky,Juan Tamargo,Samuel Wann,Sidney C. Smith,Alice K. Jacobs,Cynthia D. Adams,Jeffery L. Anderson,Elliott M. Antman,Sharon A. Hunt,Rick A. Nishimura,Joseph P. Ornato,Richard L. Page,Barbara Riegel,Silvia G. Priori,Jean Jacques Blanc,Andrzej Budaj,A. John Camm,Veronica Dean,Jaap W. Deckers,Catherine Despres,Kenneth Dickstein,John Lekakis,Keith McGregor,Marco Metra,João Morais,Ady Osterspey,José Luis Zamorano +37 more
TL;DR: A Report of the American College of Cardiology/American Heart ACC/AHA/ESC Guidelines for the Management of Patients With Atrial Fibrillation.
Journal ArticleDOI
2011 ACCF/AHA/HRS Focused Updates Incorporated Into the ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Valentin Fuster,Lars Rydén,Davis S. Cannom,Harry J.G.M. Crijns,Anne B. Curtis,Kenneth A. Ellenbogen,Jonathan L. Halperin,G. Neal Kay,Jean-Yves Le Huezey,James E. Lowe,S. Bertil Olsson,Eric N. Prystowsky,Juan Tamargo,L. Samuel Wann +13 more
TL;DR: This guideline was developed in conjunction with the European Society of Cardiology (ESC) and aims to improve the effectiveness of care, optimize patient outcomes, and favorably affect the overall cost of care by focusing resources on the most effective strategies.
References
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Journal ArticleDOI
Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. A meta-analysis of randomized control trials.
TL;DR: Quinidine treatment is more effective than no antiarrhythmic therapy in suppressing recurrences of atrial fibrillation but appears to be associated with increased total mortality.
Journal ArticleDOI
Clinical efficacy of amiodarone as an antiarrhythmic agent
Mauricio B. Rosenbaum,Pablo A. Chiale,M. Susana Halpern,Gerardo J. Nau,Julio Przybylski,Raúl J. Levi,Julio O. Lázzari,Marcelo V. Elizari +7 more
TL;DR: Amiodarone proved safe in patients with severe congestive heart failure and severe myocardial damage and liberates patients from a rigid hourly schedule and provides for continuous antiarrhythmic control, days and even weeks after treatment is discontinued.
Journal ArticleDOI
Serial antiarrhythmic drug treatment to maintain sinus rhythm after electrical cardioversion for chronic atrial fibrillation or atrial flutter.
TL;DR: It is concluded that serial treatment may improve arrhythmia prognosis in atrial fibrillation or flutter, with an acceptable incidence of proarrhythmic events.
Journal ArticleDOI
Amiodarone: clinical efficacy and toxicity in 96 patients with recurrent, drug-refractory arrhythmias.
TL;DR: In this article, the authors concluded that amiodarone is useful in the treatment of refractory tachyarrhythmias but that the rate of efficacy in VT/VF is lower and the incidence of significant toxicity is higher than has been generally appreciated.
Journal ArticleDOI
Amiodarone: historical development and pharmacologic profile
Bramah N. Singh,Bramah N. Singh +1 more
TL;DR: The safe and rational therapeutic uses of amiodarone as an antiarrhythmic agent presuppose detailed understanding of its manifold pharmacodynamic and pharmacokinetic properties.