Journal ArticleDOI
Luteinizing hormone-releasing hormone analogs: their impact on the control of tumorigenesis.
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TLDR
The development of the luteinizing hormone-releasing hormone (LH-RH) agonists and antagonists and the principles of their clinical use were reviewed and targeted cytotoxic analogs of LH-RH that can be targeted to LH- RH receptors on tumors have been synthesized and successfully tested in experimental cancer models.About:
This article is published in Peptides.The article was published on 1999-10-01. It has received 212 citations till now. The article focuses on the topics: Cancer & Prostate cancer.read more
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Journal ArticleDOI
The science behind 25 years of ovarian stimulation for in vitro fertilization.
TL;DR: The scientific background to current approaches to ovarian stimulation for in vitro fertilization is reviewed and the development, application, and consequences of ovarian stimulation strategies are reviewed in detail.
Journal ArticleDOI
Hypothalamic Hormones and Cancer
Andrew V. Schally,Andrew V. Schally,Ana Maria Comaru-Schally,Ana Maria Comaru-Schally,Attila Nagy,Attila Nagy,Magdolna Kovacs,Magdolna Kovacs,Karoly Szepeshazi,Karoly Szepeshazi,Artur Plonowski,Artur Plonowski,Jozsef L. Varga,Jozsef L. Varga,Gabor Halmos,Gabor Halmos +15 more
TL;DR: Treatment of many cancers remains a major challenge, but new therapeutic modalities are being developed based on antagonists of GH-RH and bombesin, which inhibit growth factors or their receptors, and somatostatin, which can be targeted to receptors for these peptides in various cancers and their metastases.
Journal ArticleDOI
Gonadotropin-releasing-hormone-receptor antagonists
TL;DR: In assisted reproduction, these compounds seem to be as effective as established therapy but with shorter treatment times, less use of gonadotropic hormones, improved patient acceptance, and fewer follicles and oocytes.
Journal ArticleDOI
Androgen receptors in hormone-dependent and castration-resistant prostate cancer.
TL;DR: The finding that constitutively active AR splice variants that lack the hormone binding domain are frequently expressed in CRPC highlights the need to develop therapies that target other portions of AR.
Journal ArticleDOI
In vivo properties of an anti-GnRH Spiegelmer: An example of an oligonucleotide-based therapeutic substance class
Britta Wlotzka,Susanne Leva,Bernd Eschgfäller,Jens Burmeister,Frank Kleinjung,Christine Kaduk,Peter Muhn,Holger Hess-Stumpp,Sven Klussmann +8 more
TL;DR: In a castrated rat model the Spiegelmer further demonstrated strong GnRH antagonist activity, which is more pronounced and persists longer with the polyethylene glycol-linked derivative, and in rabbits the anti-GnRH Spiegelmer was shown to have a very low, possibly negligible immunogenic potential.
References
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Journal ArticleDOI
Polycystic ovary syndrome.
TL;DR: It is now clear that the range of presenting symptoms of women with polycystic ovaries includes not only nonhirsute women with oligomenorrhoea or amenorrhOEa but also hirsute subjects with regular, ovulatory cycles.
Journal ArticleDOI
A controlled trial of leuprolide with and without flutamide in prostatic carcinoma.
E. D. Crawford,Mario A. Eisenberger,David G. McLeod,J T Spaulding,Ralph C. Benson,F A Dorr,Brent A. Blumenstein,M A Davis,P J Goodman +8 more
TL;DR: Treatment with le uprolide and flutamide is superior to treatment with leuprolide alone in patients with advanced prostate cancer, and Symptomatic improvement was greatest during the first 12 weeks of the combined androgen blockade.
Book ChapterDOI
The neuroendocrine control of the menstrual cycle.
TL;DR: The construction of a model of the neuroendocrine control system that governs the 28-day ovarian cycle of the rhesus monkey is discussed, which has three basic components: the arcuate nucleus of the hypothalamus, the gonadotrophs of the pituitary gland, and the ovary.
Journal ArticleDOI
Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone
TL;DR: The initiation of continuous GnRH administration in animals with lesions and in which gonadotropin secretion is reestablished by intermittent GnRH replacement can result in a "desensitization" or "down regulation" of the processes responsible for gonadotropic hormone release.
Journal ArticleDOI
Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence
TL;DR: The complete amino acid sequence of porcine LH- and FSH- releasing hormone has been provisionally determined by the use on a micro-scale of the combined Edman-dansyl procedure coupled with the selective tritiation method for C-terminal analysis.