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Machine Learning and Data Mining Methods in Diabetes Research.

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TLDR
A systematic review of the applications of machine learning, data mining techniques and tools in the field of diabetes research with respect to a) Prediction and Diagnosis, b) Diabetic Complications, c) Genetic Background and Environment, and e) Health Care and Management with the first category appearing to be the most popular.
Abstract
The remarkable advances in biotechnology and health sciences have led to a significant production of data, such as high throughput genetic data and clinical information, generated from large Electronic Health Records (EHRs). To this end, application of machine learning and data mining methods in biosciences is presently, more than ever before, vital and indispensable in efforts to transform intelligently all available information into valuable knowledge. Diabetes mellitus (DM) is defined as a group of metabolic disorders exerting significant pressure on human health worldwide. Extensive research in all aspects of diabetes (diagnosis, etiopathophysiology, therapy, etc.) has led to the generation of huge amounts of data. The aim of the present study is to conduct a systematic review of the applications of machine learning, data mining techniques and tools in the field of diabetes research with respect to a) Prediction and Diagnosis, b) Diabetic Complications, c) Genetic Background and Environment, and e) Health Care and Management with the first category appearing to be the most popular. A wide range of machine learning algorithms were employed. In general, 85% of those used were characterized by supervised learning approaches and 15% by unsupervised ones, and more specifically, association rules. Support vector machines (SVM) arise as the most successful and widely used algorithm. Concerning the type of data, clinical datasets were mainly used. The title applications in the selected articles project the usefulness of extracting valuable knowledge leading to new hypotheses targeting deeper understanding and further investigation in DM.

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References
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Journal ArticleDOI

A Consensus Perceived Glycemic Variability Metric

TL;DR: A consensus perceived glycemic variability metric that could be routinely applied to CGM data to assess diabetes mellitus control is developed and could be used as a routine measure of overall glucose control to supplement glycosylated hemoglobin in clinical practice.
Journal ArticleDOI

The adipogenic potential of Cr(III). A molecular approach exemplifying metal-induced enhancement of insulin mimesis in diabetes mellitus II

TL;DR: The emerging results suggest that Cr(III)-citrate is not toxic in a concentration- and time-dependent manner, has no influence on cell motility, and can induce 3T3-L1 pre-adipocyte differentiation into mature adipocytes through elevation of tissue specific biomarker levels, and exemplifies structurally-based metal-induced adipogenesis as a key process contributing to the development of future antidiabetic metallodrugs.
Journal ArticleDOI

Predicting cardiac autonomic neuropathy category for diabetic data with missing values

TL;DR: This is the first article using the Ewing formula and regression to classify CAN and it has achieved the best accuracy of 99.78% for two classes of CAN, and 98.98% for three classes ofCAN.
Proceedings Article

Survival association rule mining towards type 2 diabetes risk assessment.

TL;DR: It is demonstrated on a real diabetes data set that SARs are naturally more interpretable than the traditional association rules, and predictive models built on top of these rules are very competitive relative to state of the art survival models and substantially outperform the most widely used diabetes index, the Framingham score.
Journal ArticleDOI

Identification and Progression of Heart Disease Risk Factors in Diabetic Patients from Longitudinal Electronic Health Records

TL;DR: This study presents an information extraction system to extract related information on heart disease risk factors from unstructured clinical notes using a hybrid approach that employs both machine learning and rule-based clinical text mining techniques.
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