Journal ArticleDOI
Malondialdehyde excretion by subjects consuming cod liver oil vs a concentrate of n-3 fatty acids.
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TLDR
The results indicate that consuming unstabilized fish oils as a source of n-3 fatty acids may entail exposure to potentially toxic products of lipid peroxidation.Abstract:
Urinary malondialdehyde (MDA), an indicator of lipid peroxidation in the diat and in the tissues, was determined in human adults consuming a supplement of n-3 fatty acids derived from a pharmaceutical grade of cod liver oil (CLO) without added antioxidants vs a concentrate of n-3 acids containing dodecyl gallate and vitamin E. MDA excretion increased immediately in the subjects consuming CLO but remained unchanged in those ingesting the concentrate for 50 days. The increase in the subjects taking CLO was attributable to MDA in the oil. The results indicate that consuming unstabilized fish oils as a source of n-3 fatty acids may entail exposure to potentially toxic products of lipid peroxidation.read more
Citations
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Routes of formation and toxic consequences of lipid oxidation products in foods.
TL;DR: The presence of reactive lipid oxidation products in foods needs more systematic research in terms of complexities of food component interactions and the metabolic processing of these compounds.
Journal ArticleDOI
The biological significance of malondialdehyde determination in the assessment of tissue oxidative stress.
TL;DR: The present review emphasizes the significance of malondialdehyde measurement in biological samples, the chemical conditions of its reaction with thiobarbituric acid and the different procedures to isolate and determine the malondialsdehyde-thiobarbaric acid adduct.
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Noninvasive measures of oxidative stress status in humans.
TL;DR: One of the greatest needs in the field of free radical biology is the development of reliable methods for measuring oxidative stress status (OSS) in humans.
Journal ArticleDOI
Lipid peroxidation in turbot (Scophthalmus maximus) tissue: effect of dietary vitamin E and dietary n-6 or n-3 polyunsaturated fatty acids
TL;DR: It is demonstrated that dietary fish oil increases the susceptibility of turbot tissue to in vivo and in vitro fatty acid peroxidation, the in vitro test being more sensitive.
Journal ArticleDOI
Effect of dietary lipids and vitamin E on in vitro lipid peroxidation in rat liver and kidney homogenates.
TL;DR: Vitamin E was thus a more effective antioxidant for liver than for kidney regardless of the dietary lipid, and for liver and kidney from rats fed COL than from Rats fed MO, which enhanced tissue susceptibility to both peroxidation systems.
References
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Journal ArticleDOI
Unequivocal demonstration that malondialdehyde is a mutagen
TL;DR: Three complementary methods for the preparation of highly purified MDA are utilized and it is unequivocally demonstrated that MDA is a weak mutagen.
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Antioxidants and Cancer. IV. Initiating Activity of Malonaldehyde as a Carcinogen
TL;DR: Skin treated with DMBA, benzo[a]pyrene, and 3-methylcholanthrene had increased and the predicted reactivity of malonaldehyde was confirmed; after 1 hour, only 1.9% of the applied malcaaldehyde was detectable.
Journal ArticleDOI
Metabolism of malonaldehyde in vivo and in vitro
G. M. Siu,H. H. Draper +1 more
TL;DR: In vitro experiments using [1,3-14C] MA showed that MA is metabolized primarily in the mitochondria via reactions involving O2 utilization and14CO2 production, and 14C-Acetate appeared to be the major accumulating metabolite in rat liver mitochondrial preparations following a 120-min incubation with14C-MA.
Journal ArticleDOI
Urinary malondialdehyde as an indicator of lipid peroxidation in the diet and in the tissues
TL;DR: The results indicate that MDA excretion can serve as an indicator of the extent of lipid peroxidation in the diet and, under conditions which preclude a dietary effect, as an index of lipidper oxidation in vivo.
Journal ArticleDOI
Alteration and recovery of bleeding times, platelet aggregation and fatty acid composition of individual phospholipids in platelets of human subjects receiving a supplement of cod-liver oil
Ahmed A. Ahmed,Bruce J. Holub +1 more
TL;DR: Results suggest a close relationship of the observed fatty acid changes in individual platelet phospholipids to the altered hematological parameters and platelet-vessel wall interactions produced by cod-liver oil supplementation.