Journal ArticleDOI
Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update
John M. Kyriakis,Joseph Avruch +1 more
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TLDR
The molecular components of the mammalian stress-regulated MAPK pathways and their regulation as described thus far are summarized and some of the in vivo functions of these pathways are reviewed.Abstract:
The mammalian stress-activated families of mitogen-activated protein kinases (MAPKs) were first elucidated in 1994, and by 2001, substantial progress had been made in identifying the architecture of the pathways upstream of these kinases as well as in cataloguing candidate substrates. This information remains largely sound. Nevertheless, an informed understanding of the physiological and pathophysiological roles of these kinases remained to be accomplished. In the past decade, there has been an explosion of new work using RNAi in cells, as well as transgenic, knockout and conditional knockout technology in mice that has provided valuable insight into the functions of stress-activated MAPK pathways. These findings have important implications in our understanding of organ development, innate and acquired immunity, and diseases such as atherosclerosis, tumorigenesis, and type 2 diabetes. These new developments bring us within striking distance of the development and validation of novel treatment strategies. Herein we first summarize the molecular components of the mammalian stress-regulated MAPK pathways and their regulation as described thus far. We then review some of the in vivo functions of these pathways.read more
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Effect of salinity stress on plants and its tolerance strategies: a review.
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p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents.
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Induction ofc-fos expressionthrough JNK-mediated TCF/Elk-1 phosphorylation
Martin Cavigelli,Fabrizio Dolfi +1 more
TL;DR: It is suggested that UV irradiation and MEKK1 activation stimulate TCF/Elk‐1 activity through JNK activation, while growth factors induce c‐fos through ERK activation.
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The Oxytocin Receptor: From Intracellular Signaling to Behavior
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TNF and MAP kinase signalling pathways
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TL;DR: Mechanisms that mediate the actions of MAP kinases during the response to TNFα are reviewed.
References
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Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation
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