Journal ArticleDOI
Manipulation and flow of biological fluids in straight channels micromachined in silicon
TLDR
Flow dynamics of biological fluids and cell suspensions in straight glass-capped silicon microchannels demonstrated that these microstructures are appropriate components for microfluidic analytical devices, clearly indicating the future role of microStructures for a variety of analytical purposes.Abstract:
Analysis of minute sample volumes is a major analytical challenge that requires an understanding of fluid flow in microstructures. Accordingly, flow dynamics of biological fluids and cell suspensions in straight glass-capped silicon microchannels (40 to 150 microns wide, 20 and 40 microns deep) were studied. We demonstrated that these microstructures are appropriate components for microfluidic analytical devices. Different fluids were easily manipulated in the microchannels, and measurements of flow rate as a function of pressure for whole human blood, serum, plasma, and cell suspensions revealed non-Newtonian behavior. By means of micromachined filters (5 microns) located in channels, blood cells and microparticles were effectively separated from nanoliter-sized samples, clearly indicating the future role of microstructures for a variety of analytical purposes.read more
Citations
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Journal ArticleDOI
Rapid prototyping of microfluidic systems in poly(dimethylsiloxane)
TL;DR: A procedure that makes it possible to design and fabricate microfluidic systems in an elastomeric material poly(dimethylsiloxane) (PDMS) in less than 24 h by fabricating a miniaturized capillary electrophoresis system is described.
BookDOI
The MEMS Handbook
TL;DR: In this paper, the authors present a detailed overview of the history of the field of flow simulation for MEMS and discuss the current state-of-the-art in this field.
Patent
Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
Gregory Kellogg,Stephen G. Kieffer-Higgins,Bruce L. Carvalho,Gene A. Davis,John P. Willis,Ted Minior,Laura L. Chapman,Mikayla Kob,Sarah D. Oeltjen,Shari Ommert,Alec Mian +10 more
TL;DR: In this paper, a micro-system platform for use with a micromanipulation device to manipulate the platform by rotation, thereby utilizing the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels embedded in the microplatform.
Journal ArticleDOI
Single-phase Convective Heat Transfer in Microchannels: a Review of Experimental Results
TL;DR: In this article, a bibliographical review on the convective heat transfer through microchannels is presented, highlighting the main results obtained on the friction factor, on the laminar-to-turbulent transition and on the Nusselt number in channels having a hydraulic diameter less than 1 mm.
Journal ArticleDOI
Fabrication of plastic microfluid channels by imprinting methods.
Larissa E. Martynova,Laurie E. Locascio,Michael Gaitan,Gary W. Kramer,Richard G. Christensen,William A. MacCrehan +5 more
TL;DR: Microfluidic devices have been fabricated on poly(methyl methacrylate) substrates by two independent imprinting techniques and fluorescent analtyes were used to demonstrate reproducible electrophoretic injections.
References
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Journal ArticleDOI
Liquid transport in micron and submicron channels
TL;DR: In this article, an experimental investigation of fluid flow in extremely small channels is presented, and preliminary results pertaining to friction measurements are reported pertaining to the predictions from the Navier-Stokes equations.
Journal ArticleDOI
Microfabrication techniques for integrated sensors and microsystems
Kensall D. Wise,Khalil Najafi +1 more
TL;DR: Integrated sensors and actuators are rapidly evolving to provide an important link between very large scale integrated circuits and nonelectronic monitoring and control applications ranging from biomedicine to automated manufacturing.
Journal ArticleDOI
Cell distribution in capillary networks
TL;DR: The computational results show that, due to nonlinear cell distribution functions and non uniform flow rates, the concentration of blood cells in a capillary network will be generally nonuniform.