Journal ArticleDOI
Maternal high-fat intake predisposes nonalcoholic fatty liver disease in C57BL/6 offspring
Bianca Martins Gregório,Vanessa Souza-Mello,Jorge José de Carvalho,Carlos Alberto Mandarim-de-Lacerda,Marcia Barbosa Aguila +4 more
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TLDR
Programming by HF chow predisposes hepatic adverse remodeling in the liver of adult offspring, and insulin resistance and lower glucose transporter-2 expression were shown.About:
This article is published in American Journal of Obstetrics and Gynecology.The article was published on 2010-11-01. It has received 102 citations till now. The article focuses on the topics: Offspring & Fatty liver.read more
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Animal models of in utero exposure to a high fat diet: a review.
TL;DR: Rodent and non-human primate models provide a means to understand the underlying mechanisms of this programming effect and converging effects of a maternal high fat diet on insulin and glucose metabolism, energy balance, cardiovascular function and adiposity in offspring.
Journal ArticleDOI
Maternal Obesity and Developmental Programming of Metabolic Disorders in Offspring: Evidence from Animal Models
TL;DR: The various animal models of maternal overnutrition and their importance in the understanding of the mechanisms underlying altered obesity risk in offspring are discussed.
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Maternal Obesity, Inflammation, and Developmental Programming
TL;DR: Use of nutritional anti-inflammatories in pregnancy including omega 3 fatty acids, resveratrol, curcumin, and taurine may provide beneficial intervention strategies to ameliorate maternal obesity-induced programming.
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Endocrine-disrupting chemicals and fatty liver disease.
TL;DR: This work focuses on one class of endocrine-disrupting chemicals (EDCs) and their potential to influence the initiation and progression of a cascade of pathological conditions associated with hepatic steatosis (fatty liver), and several potential mechanisms by which EDC exposure might contribute to disease pathogenesis.
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Maternal high-fat diet in mice programs emotional behavior in adulthood.
TL;DR: It is found that offspring born to high-fat diet mothers showed increased anxiety-like behaviors, but intact conditioned fear response and exploratory behavior, suggesting that maternal high-Fat diet consumption during critical periods in the development of the fetus, might increase the risk of abnormal behaviors in adulthood related to anxiety.
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Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
TL;DR: The correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
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AIN-93 Purified Diets for Laboratory Rodents: Final Report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet
TL;DR: Two new diets may prove to be a better choice than AIN-76A for long-term as well as short-term studies with laboratory rodents because of a better balance of essential nutrients.
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Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
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Living with the past: evolution, development, and patterns of disease
Peter D. Gluckman,Mark A. Hanson +1 more
TL;DR: Research in evolutionary biology, developmental biology, and animal and human physiology suggests that environmental processes influencing the propensity to disease in adulthood operate during the periconceptual, fetal, and infant phases of life.