Maternal HLA panel-reactive antibodies in early gestation positively correlate with chronic chorioamnionitis: evidence in support of the chronic nature of maternal anti-fetal rejection.
JoonHo Lee,Roberto Romero,Yi Xu,Jung Sun Kim,Ji Young Park,Juan Pedro Kusanovic,Juan Pedro Kusanovic,Tinnakorn Chaiworapongsa,Tinnakorn Chaiworapongsa,Sonia S. Hassan,Sonia S. Hassan,Chong Jai Kim,Chong Jai Kim +12 more
TLDR
Maternal HLA panel‐reactive antibodies in early gestation positively correlate with chronic chorioamnionitis, evidence in support of the chronic nature of maternal anti‐fetal rejection.Abstract:
Problem
Maternal tolerance of the fetus is essential for viviparity, yet anti-fetal rejection occurs in several pregnancy complications. Chronic chorioamnionitis (CCA) is a feature of anti-fetal cellular rejection. There is a robust association between CCA and maternal seropositivity for anti-HLA panel reactive antibodies (PRA) at the time of delivery. This longitudinal study was performed to assess maternal HLA PRA status in early gestation and the temporal evolution of maternal HLA PRA in the context of CCA and thereby to determine whether HLA PRA during the course of pregnancy is useful for the detection of anti-fetal rejection.read more
Citations
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Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance
TL;DR: Chronic placental inflammatory lesions can be due to maternal anti-fetal rejection, a process associated with the development of a novel form of fetal systemic inflammatory response.
Journal ArticleDOI
A blueprint for the prevention of preterm birth: vaginal progesterone in women with a short cervix.
Roberto Romero,Lami Yeo,Jezid Miranda,Sonia S. Hassan,Agustin Conde-Agudelo,Tinnakorn Chaiworapongsa +5 more
TL;DR: Routine assessment of the risk of preterm birth with cervical ultrasound coupled with vaginal progesterone for women with a short cervix is cost-effective, and the implementation of such a policy is urgently needed.
Journal ArticleDOI
Midtrimester amniotic fluid concentrations of interleukin-6 and interferon-gamma-inducible protein-10: evidence for heterogeneity of intra-amniotic inflammation and associations with spontaneous early ( 32 weeks) preterm delivery.
Maria Teresa Gervasi,Roberto Romero,Gabriella Bracalente,Offer Erez,Zhong Dong,Sonia S. Hassan,Lami Yeo,Bo Hyun Yoon,Tinnakorn Chaiworapongsa +8 more
TL;DR: Although each type of inflammation is a risk factor for spontaneous preterm delivery, many patients had a term delivery without complication; and the amniotic fluid in the midtrimester did not contain microorganisms detectable with cultivation techniques.
Journal ArticleDOI
Evidence for a Role for the Adaptive Immune Response in Human Term Parturition
Nardhy Gomez-Lopez,Rodrigo Vega-Sanchez,Marisol Castillo-Castrejon,Roberto Romero,Karen Cubeiro-Arreola,Felipe Vadillo-Ortega +5 more
TL;DR: The purpose of this study was to characterize the immunophenotype of choriodecidual leukocytes as well as the expression of inflammatory mediators in human spontaneous parturition at term.
Journal ArticleDOI
Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease.
TL;DR: The purpose of this review is to describe the main inflammatory processes in the placenta, discuss their immunology, and relate their short- and long-term disease associations.
References
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Stacy Beck,Daniel Wojdyla,Lale Say,Ana Pilar Betrán,Mario Merialdi,Jennifer Harris Requejo,Craig E Rubens,Ramkumar Menon,Paul F.A. Van Look +8 more
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Banff 07 Classification of Renal Allograft Pathology: Updates and Future Directions
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TL;DR: Emerging research data led to the establishment of collaborative working groups addressing issues like isolated ‘v’ lesion and incorporation of omics‐technologies, paving the way for future combination of graft biopsy and molecular parameters within the Banff process.
Journal Article
The Worldwide Incidence of Preterm Birth: A Systematic Review of Maternal Mortality and morbidity/Incidence Mondiale De la Missance Avant Terme: Revue Sytemtique De la Mortalite et De la Morbidite maternelle/Incidencia Mundial De Parto Prematuro: Revision Sistematica De la Morbilidad Y Mortalidad Maternas
Stacy Beck,Daniel Wojdyla,Lale Say,Ana Pilar Betrán,Mario Merialdi,Jennifer Harris Requejo,Craig E. Rubens,Ramkumar Menon,Paul F.A. Van Look +8 more
TL;DR: Preterm birth, defined as childbirth occurring at less than 37 completed weeks or 259 days of gestation, is a major determinant of neonatal mortality and morbidity and has long-term adverse consequences for health as mentioned in this paper.
Journal ArticleDOI
The preterm parturition syndrome
Roberto Romero,Jimmy Espinoza,Juan Pedro Kusanovic,Francesca Gotsch,Sonia S. Hassan,Offer Erez,Tinnakorn Chaiworapongsa,Moshe Mazor +7 more
TL;DR: The evidence indicating that the pathological processes implicated in the preterm parturition syndrome include: intrauterine infection/inflammation; uterine ischaemia; (3) uterine overdistension; (4) abnormal allograft reaction; (5) allergy; (6) cervical insufficiency; and (7) hormonal disorders (progesterone related and corticotrophin‐releasing factor related).