Evidence for a Role for the Adaptive Immune Response in Human Term Parturition
Nardhy Gomez-Lopez,Rodrigo Vega-Sanchez,Marisol Castillo-Castrejon,Roberto Romero,Karen Cubeiro-Arreola,Felipe Vadillo-Ortega +5 more
TLDR
The purpose of this study was to characterize the immunophenotype of choriodecidual leukocytes as well as the expression of inflammatory mediators in human spontaneous parturition at term.Abstract:
Problem
Spontaneous labor at term involves leukocyte recruitment and infiltration into the choriodecidua; yet, characterization of these leukocytes and their immunological mediators is incomplete. The purpose of this study was to characterize the immunophenotype of choriodecidual leukocytes as well as the expression of inflammatory mediators in human spontaneous parturition at term.
Method of study
Choriodecidual leukocytes were analyzed by FACS, immunohistochemistry, and RT-PCR in three different groups: (i) preterm gestation delivered for medical indications without labor; (ii) term pregnancy without labor; and (iii) term pregnancy after spontaneous labor.
Results
Two T-cell subsets of memory-like T cells (CD3+CD4+CD45RO+ and CD3+CD4−CD8−CD45RO+ cells) were identified in the choriodecidua of women who had spontaneous labor. Evidence for an extensive immune signaling network composed of chemokines (CXCL8 and CXCL10), chemokine receptors (CXCR1-3), cytokines (IL-1β and TNF-α), cell adhesion molecules, and MMP-9 was identified in these cells during spontaneous labor at term.
Conclusions
The influx of memory-like T cells in the choriodecidua and the evidence that they are active by producing chemokines and cytokines, and expressing chemokine receptors, cell adhesion molecules, and a matrix-degrading enzyme provides support for the participation of the adaptive immune system in the mechanisms of spontaneous parturition at term.read more
Citations
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Journal ArticleDOI
Immune cells in term and preterm labor
Nardhy Gomez-Lopez,Derek StLouis,Marcus A Lehr,Elly N. Sanchez-Rodriguez,Marcia Arenas-Hernandez +4 more
TL;DR: A balance between innate and adaptive immune cells is required in order to sustain pregnancy; an alteration of this balance will lead to labor at term or preterm.
Journal ArticleDOI
Dynamic Function and Composition Changes of Immune Cells During Normal and Pathological Pregnancy at the Maternal-Fetal Interface.
TL;DR: Information from previous studies is summarized, which may lay the foundation for the diagnosis of pathological pregnancy and put forward new ideas for future studies about dynamic changes in immune cells in mid and late pregnancy.
Journal ArticleDOI
Novel concepts on pregnancy clocks and alarms: redundancy and synergy in human parturition
TL;DR: A comprehensive synthesis of the mediators that contribute to the timing of human labor is provided, putting forth the core hypothesis that fetal membrane (amnion and chorion) senescence is the initiator of a coordinated, redundant signal cascade leading to parturition.
Journal ArticleDOI
An M1-like Macrophage Polarization in Decidual Tissue during Spontaneous Preterm Labor That Is Attenuated by Rosiglitazone Treatment.
Yi Xu,Roberto Romero,Derek Miller,Leena Kadam,Tara N. Mial,Tara N. Mial,Olesya Plazyo,Valeria Garcia-Flores,Valeria Garcia-Flores,Sonia S. Hassan,Sonia S. Hassan,Zhonghui Xu,Zhonghui Xu,Adi L. Tarca,Adi L. Tarca,Sascha Drewlo,Nardhy Gomez-Lopez,Nardhy Gomez-Lopez +17 more
TL;DR: It is demonstrated that decidual M1-like macrophages are associated with spontaneous preterm labor and that PPARγ activation via RSG can attenuate the macrophage-mediated proinflammatory response, preventing preterm birth and improving neonatal outcomes.
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