Measurement of plasma hydrogen sulfide in vivo and in vitro
Xinggui Shen,Christopher B. Pattillo,Sibile Pardue,Shyamal C. Bir,Rui Wang,Christopher G. Kevil +5 more
TLDR
A very sensitive method of measuring the presence of H₂S in plasma down to nanomolar levels, using monobromobimane (MBB), suitable for sensitive quantitative measurement of free hydrogen sulfide in multiple biological samples such as plasma, tissue and cell culture lysates, or media.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2011-05-01 and is currently open access. It has received 292 citations till now. The article focuses on the topics: Sulfide & Hydrogen sulfide.read more
Citations
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Journal ArticleDOI
Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed
TL;DR: The important life-supporting role of hydrogen sulfide (H(2)S) has evolved from bacteria to plants, invertebrates, vertebrate, vertebrates, and finally to mammals, but over the centuries it had only been known for its toxicity and environmental hazard.
Journal ArticleDOI
Chemical Biology of H2S Signaling through Persulfidation.
TL;DR: The biologically relevant chemistry of H2S and the enzymatic routes for its production and oxidation are discussed and the roles ascribed to protein persulfidation in cell signaling pathways are discussed.
Journal ArticleDOI
Capture and Visualization of Hydrogen Sulfide by a Fluorescent Probe
Chunrong Liu,Jia Pan,Sheng Li,Yu Zhao,Lisa Y. Wu,Clifford E. Berkman,A. Richard Whorton,Ming Xian +7 more
TL;DR: A reaction-based fluorescent turn-on strategy for the detection of H2S, which has been shown to relax vascular smooth muscle, induce vasodilation of isolated blood vessels, and reduce blood pressure, and is a potent anti-inflammatory molecule.
Journal ArticleDOI
Polysulfides Link H2S to Protein Thiol Oxidation
Romy Greiner,Zoltán Pálinkás,Katrin Bäsell,Dörte Becher,Haike Antelmann,Péter Nagy,Tobias P. Dick +6 more
TL;DR: This study suggests that the effects that have been attributed to H2S in previous reports may in fact have been mediated by polysulfides, and supports the notion that sulfane sulfur rather than sulfide is the actual in vivo agent of H 2S signaling.
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Selective turn-on fluorescent probes for imaging hydrogen sulfide in living cells
TL;DR: Two bright fluorescent probes are reported that are selective for H( 2)S over cysteine, glutathione and other reactive sulfur, nitrogen, and oxygen species and are demonstrated to detect H(2)S in live cells.
References
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Journal ArticleDOI
The possible role of hydrogen sulfide as an endogenous neuromodulator
Kazuho Abe,Hideo Kimura +1 more
TL;DR: It is shown that physiological concentrations of H2S selectively enhance NMDA receptor-mediated responses and facilitate the induction of hippocampal long-term potentiation, suggesting that endogenous H 2S functions as a neuromodulator in the brain.
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The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener
TL;DR: It is demonstrated that H2S is an important endogenous vasoactive factor and the first identified gaseous opener of KATP channels in vascular SMCs and production from vascular tissues was enhanced by nitric oxide.
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A Critical Review of the Literature on Hydrogen Sulfide Toxicity
TL;DR: This review of the literature is intended as an evaluative report rather than an annotated bibliography of all the source material examined on hydrogen sulfide, noting information gaps that may require further investigation.
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Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat.
Martha H. Stipanuk,P W Beck +1 more
TL;DR: There was no significant effect of propargylglycine administration on the urinary excretion of total 35S, 35SO4(2-) or [35S]taurine formed from labelled dietary cysteine.
Journal ArticleDOI
Endogenous hydrogen sulfide overproduction in Down syndrome.
Pierre Kamoun,Maria-Cristina Belardinelli,Allel Chabli,Karim Lallouchi,Bernadette Chadefaux-Vekemans +4 more
TL;DR: The cystathionine beta synthase (CBS) gene is localized on chromosome 21 (21q22.3) and this overproduction is potentially able to induce some of the clinical signs of Down syndrome such as hypotonia and mental retardation.
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The possible role of hydrogen sulfide as an endogenous neuromodulator
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