Journal ArticleDOI
Mechanical properties and in vitro degradation of bioresorbable fibers and expandable fiber-based stents.
TLDR
In this article, the effect of degradation on the tensile mechanical properties and morphology of poly(L-lactide) and polydioxanone (PDS) fibers was examined.Abstract:
Bioresorbable polymeric support devices (stents) are being developed in order to improve the biocompatibility and drug reservoir capacity of metal stents, as well as to offer a temporary alternative to permanent metallic stents. These temporary devices may be utilized for coronary, urethral, tracheal, and other applications. The present study focuses on the mechanical properties of bioresorbable fibers as well as stents developed from these fibers. Fibers made of poly(L-lactide) (PLLA), polydioxanone (PDS), and poly(glycolide-co--capro- lactone) (PGACL) were studied in vitro. These fibers combine a relatively high initial strength and modulus together with sufficient ductility and flexibility, and were therefore chosen for use in stents. The effect of degradation on the tensile mechanical properties and morphology of these fibers was examined. The expandable stents developed from these fibers demonstrated excellent initial radial compression strength. The PLLA stents exhibited excellent in vitro degradation resistance and can therefore support body conduits such as blood vessels for prolonged periods of time. PDS and PGACL stents can afford good support for 5 and 2 weeks, respectively, and can therefore be utilized for short-term applications. The degradation resistance of the stents correlates with the profile of mechanical property deterioration of the corresponding bioresorbable fibers. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 74B: 792-799, 2005read more
Citations
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Journal ArticleDOI
Biodegradable polymers as biomaterials
TL;DR: This review summarizes the main advances published over the last 15 years, outlining the synthesis, biodegradability and biomedical applications ofBiodegradable synthetic and natural polymers.
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Polymeric scaffolds in tissue engineering application: a review
TL;DR: An overview of the different types of scaffolds with their material properties is discussed and the fabrication technologies for tissue engineering scaffolds, including the basic and conventional techniques to the more recent ones, are tabulated.
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Industrial Upscaling of Electrospinning and Applications of Polymer Nanofibers: A Review
TL;DR: In this paper, the authors focus on relevant technological approaches developed by research, which show perspectives for scaling-up and for fulfilling requirements of industrial production in terms of throughput, accuracy, and functionality of the realized nanofibers.
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Biodegradable Polymers- A Review on Recent Trends and Emerging Perspectives
TL;DR: A review of the state-of-the-art on biodegradable polymers can be found in this paper, where the salient features of the design and properties of these polymers are discussed.
Journal ArticleDOI
Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering.
Qingwei Zhang,Vadym Mochalin,Ioannis Neitzel,Kavan Hazeli,Junjie Niu,Antonios Kontsos,Jack G. Zhou,Peter I. Lelkes,Yury Gogotsi +8 more
TL;DR: The enhanced mechanical properties and the increased mineralization capability with higher ND-ODA concentration suggest that these biodegradable composites may potentially be useful for a variety of biomedical applications, including scaffolds for orthopedic regenerative engineering.
References
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Book
Principles of tissue engineering
TL;DR: The history and Scope of Tissue Engineering, J.P. Vavanti and C.A. Vacanti, and Quantitative Aspects of Tissues Engineering: Basic Issues in Kinetics, Transport, and Mechanics are reviewed.
Journal ArticleDOI
Initial and 6-Month Results of Biodegradable Poly-l-Lactic Acid Coronary Stents in Humans
Hideo Tamai,Keiji Igaki,Eisho Kyo,Kunihiko Kosuga,Akiyoshi Kawashima,Shigeo Matsui,Hidenori Komori,Takafumi Tsuji,Seiichiro Motohara,Hiromu Uehata +9 more
TL;DR: The preliminary experience suggests that coronary PLLA biodegradable stents are feasible, safe, and effective in humans, and Long-term follow-up with more patients will be required to validate the long-term efficacy of PLLa stents.
Journal ArticleDOI
Late degradation tissue response to poly(l-lactide) bone plates and screws
TL;DR: The results of this investigation suggest that the poly(L-lactic acid (PLLA) material slowly degrades into particles with a high crystallinity as mentioned in this paper, and after 5.7 years of implantation these particles were still not fully resorbed.
Journal ArticleDOI
Foreign body reactions to resorbable poly(l-lactide) bone plates and screws used for the fixation of unstable zygomatic fractures
TL;DR: The long-term results in patients treated with solitary, unstable, displaced zygomatic fractures using resorbable poly(L-lactide) (PLLA) plates and screws are described.