Journal ArticleDOI
Mechanism of repair of DNA in bacteriophage: II. Inability of ultraviolet-sensitive strains of bacteriophage in inducing an enzyme activity to excise pyrimidine dimers
Seiichi Yasuda,Mutsuo Sekiguchi +1 more
TLDR
The results suggest that the T4-induced dimer-excising activity may be concerned with dark repair of ultraviolet-damaged DNA in vivo, compatible with the finding in vivo that the v + gene product enhances the survival of not only T4 but also T2 and E. coli exposed to ultraviolet radiation.About:
This article is published in Journal of Molecular Biology.The article was published on 1970-01-28. It has received 69 citations till now. The article focuses on the topics: Pyrimidine dimer & DNA repair.read more
Citations
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Journal ArticleDOI
Bacteriophage T4 Genome
TL;DR: T4 functional genomics will aid in the interpretation of these newly sequenced T4-related genomes and in broadening the understanding of the complex evolution and ecology of phages—the most abundant and among the most ancient biological entities on Earth.
Journal ArticleDOI
T4 Endonuclease Involved in Repair of DNA
Seiichi Yasuda,Mutsuo Sekiguchi +1 more
TL;DR: An enzyme activity, named T4 endonuclease V, was purified from T4-infected Escherichia coli and appears to be responsible for the first step of excision repair.
Journal ArticleDOI
Dark Repair of Ultraviolet-Irradiated Deoxyribonucleic Acid by Bacteriophage T4: Purification and Characterization of a Dimer-Specific Phage-Induced Endonuclease
Errol C. Friedberg,John J. King +1 more
TL;DR: The purification and properties of an ultraviolet (UV) repair endonuclease are described and the specific substrate in UV-irradiated DNA appears to be pyrimidine dimer sites.
Book ChapterDOI
Molecular repair, wound healing, and carcinogenesis: tumor production a possible overhealing?
TL;DR: The chapter presents the reports of photoreactivation that specify that the damage brought about by a particular wavelength of light irradiation could be annulled or prevented by radiation with others.
References
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Journal ArticleDOI
Sedimentation studies of the size and shape of dna.
TL;DR: Analytical zone sedimentation ( Vinograd, Bruner, Kent & Weigle, 1963) is shown to be a sensitive and reliable method for detecting differences in conformation and for determining the molecular weight of homogeneous phage DNA's.
Journal ArticleDOI
Endonuclease-I-deficient and ribonuclease I-deficient Escherichia coli mutants.
TL;DR: A method has been developed to select for Escherichia coli mutants which lack certain nucleases, and mutants deficient in endonuclease I or RNase I were essentially identical to wild-type with respect to their general biological properties.
Journal ArticleDOI
Mutants of phage T4 with increased sensitivity to ultraviolet.
TL;DR: There are now available in phage T4 four sensitivity levels, represented by the genotypes v + x + (wild type), v +x , v x + , and v x , with relative sensitivities of 0.45, 0.75, 1.0, and 2.0; the slopes of the multicomplex survival curves obtained with the different sensitivity types do not show any simple correlation with the slope of the monocomplex survival curve.
Journal ArticleDOI
Physicochemical studies on the reaction between formaldehyde and DNA.
TL;DR: Evidence which suggests that preformed single-strand interruptions may exist in phage DNA is briefly discussed, and some experimental applications of the denaturation technique are given.
Journal ArticleDOI
The synthesis of messenger RNA without protein synthesis: II. Synthesis of phage-induced RNA and sequential enzyme production*
TL;DR: It is suggested that the early RNA determines early proteins alone, and that the sequential production of phage proteins is determined by the sequentialProduction of ph age-induced RNA.
Related Papers (5)
Endonucleolytic cleavage of UV-irradiated DNA controlled by the V+ gene in phage T4
Errol C. Friedberg,John J. King +1 more
Dark Repair of Ultraviolet-Irradiated Deoxyribonucleic Acid by Bacteriophage T4: Purification and Characterization of a Dimer-Specific Phage-Induced Endonuclease
Errol C. Friedberg,John J. King +1 more