Journal ArticleDOI
Mechanisms of antidiabetic effects of flavonoid rutin.
TLDR
The results of current experimental studies support the potential of rutin to prevent or treat pathologies associated with diabetes, and well-designed clinical studies are suggested to evaluate advantages and limits of r Rutin for managing diabetes.About:
This article is published in Biomedicine & Pharmacotherapy.The article was published on 2017-12-01. It has received 265 citations till now. The article focuses on the topics: Rutin.read more
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In vitro antioxidant properties of rutin
TL;DR: In this paper, the antioxidant activity of the rutin (quercetin-3-rhamnosyl glucoside) using different assays including: total antioxidant activity and reducing power, hydroxyl radical scavenging assay, superoxide radical scavengence assay, 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavengent assay and lipid peroxidation assay which uses egg yolk as the lipid-rich source.
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Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels
TL;DR: The aim of this review is to summarize the current knowledge addressing the antidiabetic effects of dietary flavonoids and their underlying molecular mechanisms on selected pathways: Glucose transporter, hepatic enzymes, tyrosine kinase inhibitor, AMPK, PPAR, and NF-κB.
Journal ArticleDOI
Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms.
TL;DR: The aim of this paper was to overview the activities and underlying mechanisms of NPs against type 2 diabetes mellitus, and developments of anti‐T2DM agents will be greatly promoted with the increasing comprehensions of N Ps for their multiple regulating effects on various targets and signal pathways.
Journal ArticleDOI
Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action
Mithun Rudrapal,Shubham Jagdish Khairnar,Johra Khan,Abdulaziz Bin Dukhyil,Mohammad Azam Ansari,Mohammad N. Alomary,Fahad M. Alshabrmi,Santwana Palai,Prashanta Kumar Deb,Rajlakshmi Devi +9 more
TL;DR: Pre-clinical and clinical evidence strongly suggest that long term consumption of diets rich in polyphenols offer protection against the development of various chronic diseases such as neurodegenerative diseases, cardiovascular diseases (CVDs), cancer, diabetes, inflammatory disorders and infectious illness.
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Health Benefits and Chemical Composition of Matcha Green Tea: A Review
TL;DR: In this article, a review of the health benefits of matcha tea is presented, and the main bioactive compounds in a systematic manner, including theanine, caffeine, chlorophyll and various types of catechins.
References
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The pathobiology of diabetic complications: a unifying mechanism.
TL;DR: What was learned about the pathobiology of diabetic complications starting with that 1966 Science paper and continuing through the end of the 1990s are described, including a unified mechanism that links together all of the seemingly unconnected pieces of the puzzle.
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Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships.
TL;DR: The antioxidant and prooxidant behavior of flavonoids and the related activity-structure relationships were investigated in this study using the oxygen radical absorbance capacity assay.
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Inflammatory Cytokines in Vascular Dysfunction and Vascular Disease
TL;DR: Genetic and pharmacological tools to decrease the production of cytokines or to diminish their effects using cytokine antagonists could provide new approaches in the management of inflammatory vascular disease.
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Advanced Glycation End Products and Diabetic Complications
TL;DR: The glycation of plasma proteins such as albumin, fibrinogen, globulins and collagen to form different types of AGEs is discussed and the role of A GEs in the pathogenesis of diabetic complications including retinopathy, cataract, neuropathy, nephropathy and cardiomyopathy is discussed.
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Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications
Pedro Geraldes,George L. King +1 more
TL;DR: Understanding of how PKC isoforms cause vascular dysfunctions and pathologies in diabetes is reviewed, with some positive results for diabetic nonproliferative retinopathy, nephropathy, and endothelial dysfunction.