Raghad Khalid Al-Ishaq

TL;DR: The aim of this review is to summarize the current knowledge addressing the antidiabetic effects of dietary flavonoids and their underlying molecular mechanisms on selected pathways: Glucose transporter, hepatic enzymes, tyrosine kinase inhibitor, AMPK, PPAR, and NF-κB.

TL;DR: The potential role of flavonoids in the modulation of signaling pathways that are crucial for COVID-19 disease, particularly those related to inflammation and immunity, was discussed in this paper.

TL;DR: Overall, phytochemicals improve cancer prognosis through the downregulation of β-catenin phosphorylation, therefore enhancing apoptosis, and upregulation of the AMPK pathway, which supports cellular homeostasis.

TL;DR: In-depth analysis of anti-inflammatory properties of flavonoids is provided, corresponding mechanisms and targeted molecular pathways are highlighted, and potential treatment models for multi-level cancer prevention in the framework of predictive, preventive, and personalized medicine are proposed.

TL;DR: In this article , a detailed data analysis is essential to adapt treatment algorithms to individuals' and patients' needs, and advanced concepts of patient stratification, predictive diagnostics, targeted prevention, and treatments tailored to the individualized patient profile are instrumental for the cost-effective application of natural anti-cancer substances to improve overall breast cancer management.