Journal ArticleDOI
Medallion-like dermal dendrocyte hamartoma: A new clinically and histopathologically distinct lesion
Rodolfo Rodriguez-Jurado,Carolina Palacios,Carola Durán-McKinster,Patricia Mercadillo,Luz Orozco-Covarrubias,María del Mar Sáez-de-Ocariz,Ramón Ruiz-Maldonado +6 more
TLDR
Three female patients presenting a medallion-shaped, well-defined, slightly atrophic and asymptomatic congenital lesion are reported, believed to represent a new, clinically and histopathologically distinct lesion originating in dermal dendrocytes.Abstract:
Dermal dendrocyte hamartomas are extremely rare; only two examples have been described with clinical features different from our cases and with incomplete immunohistochemical characterization. We report three female patients presenting a medallion-shaped, well-defined, slightly atrophic and asymptomatic congenital lesion. All 3 patients showed a fusiform-cell proliferation. Immunohistochemistry was positive for CD34, factor XIIIa, and fascin. Electron microscopy showed typical features of dermal dendrocytes. We believe that the lesions described represent a new, clinically and histopathologically distinct lesion originating in dermal dendrocytes. We propose to name it medallion-like dermal dendrocyte hamartoma.read more
Citations
More filters
Journal ArticleDOI
CD34+ stromal cells/fibroblasts/fibrocytes/telocytes as a tissue reserve and a principal source of mesenchymal cells. Location, morphology, function and role in pathology.
Lucio Díaz-Flores,R. Gutiérrez,Mª Pino García,Francisco José Sáez,Francisco Valladares,Juan Francisco Madrid +5 more
TL;DR: The morphofunctional characteristics of CD34+ stromal fibroblastic/fibrocytic cells (CD34+ SFCs) are reviewed and their in vivo behaviour during proliferation and differentiation in different physiologic and pathologic conditions is explained.
Journal ArticleDOI
A clinical, histologic, and molecular study of 9 cases of congenital dermatofibrosarcoma protuberans.
Georges Maire,Sylvie Fraitag,Louise Galmiche,Frédérique Keslair,Nathalie Ebran,Marie-José Terrier-Lacombe,Yves de Prost,Florence Pedeutour +7 more
TL;DR: This study illustrates the difficulties and pitfalls of the recognition of congenital DFSP and emphasizes the value of immunohistochemical study with anti-CD34 and complementary molecular analysis for all cutaneous spindle cell tumors and plaques in neonates and infants.
Journal ArticleDOI
CD34‐reactive tumors of the skin. An updated review of an ever‐growing list of lesions
TL;DR: The CD34 expression plays a key role in the differential diagnosis of some tumors, such as dermatofibrosarcoma protuberans, epithelioid sarcoma or pleomorphic hyalinizing angiectatic tumor of soft parts, with important therapeutic consequences and can help to resolve diagnostic problems in concrete cases.
Journal ArticleDOI
Plaque-like CD34-positive dermal fibroma ("medallion-like dermal dendrocyte hamartoma"): clinicopathologic, immunohistochemical, and molecular analysis of 5 cases emphasizing its distinction from superficial, plaque-like dermatofibrosarcoma protuberans.
Heinz Kutzner,Thomas Mentzel,Gabriele Palmedo,Markus Hantschke,Arno Rütten,Bruno E. Paredes,Leo Schärer,Carlos Guillén,Luis Requena +8 more
TL;DR: It is shown that PDF/DH and superficial (plaque-like) DFSP, subtle clinicopathologic differences notwithstanding, are morphologic look-alikes that can be kept apart by molecular studies of the COL1A1-PDGFB gene fusion.
References
More filters
Book
Diagnostic histopathology of tumors
TL;DR: Tumors of the Heart and Pericardium, including the Hepatobiliary System, and the Autonomic Nervous System (Including Paraganglia).
Book
Lever's Histopathology of the Skin
TL;DR: Lever's histopathology of the skin is concerned with the determination of histopathological changes in the response of the immune system to various types of injuries.
Journal ArticleDOI
Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases
Stefano Pileri,T. M. Grogan,Nancy L. Harris,Peter A. Banks,Elias Campo,John K.C. Chan,Riccardo Dalla Favera,Georges Delsol,C De Wolf-Peeters,Brunangelo Falini,Randy D. Gascoyne,P. Gaulard,Kevin C. Gatter,Peter G. Isaacson,Elaine S. Jaffe,Philippus Kluin,Daniel M. Knowles,David Y. Mason,Shigeo Mori,H.K. Müller-Hermelink,M A Piris,E. Ralfkiaer,H Stein,Ih-Jen Su,Roger A. Warnke,Lawrence M. Weiss +25 more
TL;DR: Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases shows clear trends in prognosis and disease progression.
Journal ArticleDOI
The Human Progenitor Cell Antigen (CD34) Is Localized on Endothelial Cells, Dermal Dendritic Cells, and Perifollicular Cells in Formalin-Fixed Normal Skin, and on Proliferating Endothelial Cells and Stromal Spindle-Shaped Cells in Kaposi's Sarcoma
TL;DR: In patch/plaque--and tumor-stage acquired immunodeficiency syndrome-associated Kaposi's sarcoma lesions, CD34 expression was present on both the proliferating endothelial cells as well as the spindle-shaped stromal cells.