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Journal ArticleDOI
Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence.
Masaharu Noda,Shin Shimizu,Tsutomu Tanabe,Toshiyuki Takai,Toshiaki Kayano,Takayuki Ikeda,Hideo Takahashi,Hitoshi Nakayama,Yuichi Kanaoka,Naoto Minamino,Kenji Kangawa,Hisayuki Matsuo,Michael A. Raftery,Tadaaki Hirose,Seiichi Inayama,Hidenori Hayashida,Takashi Miyata,Shosaku Numa +17 more
TL;DR: Cloning and sequence analysis of cDNA for the Electrophorus electricus electroplax sodium channel indicate that this protein exhibits four repeated homology units, which are presumably oriented in a pseudosymmetric fashion across the membrane.
Journal ArticleDOI
Ohmic conductance through the inwardly rectifying K channel and blocking by internal Mg2
TL;DR: It is reported here that the channel conductance is ohmic and that the well-known inward rectification of the resting K Conductance is caused by rapid closure of the channel accompanied by a voltage-dependent block by intracellular Mg2+ ions at physiological concentrations.
Journal ArticleDOI
Conduction and selectivity in potassium channels.
TL;DR: Ion channels are integral membrane proteins spanning the lipid bilayer and necessarily communicating with both aqueous phases, and may be considered as enzymes, in that they reduce the energies of transmembrane ionic diffusion from the 250 kJ/mol above to values in the range of 20 kj/mol a rate enhancement of about 1039.
Journal ArticleDOI
Molecular model of the action potential sodium channel.
H R Guy,P Seetharamulu +1 more
TL;DR: Secondary and tertiary structural models of sodium channel transmembrane segments were developed from its recently determined primary sequence in Electrophorus electricus, and found that channel activation may involve a 'helical screw' mechanism in which S4 helices rotate around their axes as they move toward the extracellular surface.
Journal ArticleDOI
Ionic selectivity revisited: The role of kinetic and equilibrium processes in ion permeation through channels
George Eisenman,Richard Horn +1 more
TL;DR: The intent of this paper is to bring up to date an earlier theory of equilibrium selectivity, with emphasis on making it applicable to the permeation of membrane channels and carriers, which involve kinetic considerations.
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A. L. Hodgkin,A. F. Huxley +1 more