Journal ArticleDOI
Merkel cell carcinoma - pathogenesis, clinical aspects and treatment
David Schrama,Jürgen C. Becker +1 more
Reads0
Chats0
TLDR
Recent findings of the pathogenesis of MCC are summarized, an overview of clinical aspects are presented and treatment options for MCCs are discussed.Abstract:
Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin demonstrating a high rate of recurrence and metastasis. Indeed, 5-year rates for MCC specific survival are only about 60%. Although MCCs’ incidence is rapidly increasing, it is still a very rare tumour. In this regard, the American Cancer Society had estimated for 2008 almost 1500 new cases in the USA. Recently, the newly identified Merkel cell polyomavirus has been found associated with most of the MCC cases. Nevertheless, the pathogenesis of MCC is not yet fully understood. Here, we will summarize recent findings of the pathogenesis of MCC, present an overview of clinical aspects and discuss treatment options for MCCs.read more
Citations
More filters
Journal ArticleDOI
Merkel cell carcinoma: Epidemiology, prognosis, therapy and unmet medical needs.
Dirk Schadendorf,Céleste Lebbé,Axel zur Hausen,M.-F. Avril,Subramanian Hariharan,Murtuza Bharmal,Juergen C. Becker +6 more
TL;DR: Patients with advanced disease are encouraged to participate in clinical trials for treatment, indicating the largely unmet need for durable, safe treatment within this population.
Journal ArticleDOI
Merkel cell carcinoma: recent insights and new treatment options.
TL;DR: This review summarizes recent findings on MCC pathogenesis with a special emphasis on the impact of MCV, presents an overview of clinical aspects, and discusses treatment options.
Journal ArticleDOI
BET protein inhibitor JQ1 attenuates Myc-amplified MCC tumor growth in vivo
TL;DR: The results provide initial evidence, indicating the potential clinical utility of BET protein inhibitors in the treatment of MCC with pathologic activation of c-Myc, and JQ1 significantly attenuates tumor growth in xenograft MCC mouse models.
Journal ArticleDOI
Merkel Cell Carcinoma Dependence on Bcl-2 Family Members for Survival
Monique Verhaegen,Doris Mangelberger,Jack W. Weick,Tracy D. Vozheiko,Paul W. Harms,Kevin Tyler Nash,Elsa Quintana,Paul Baciu,Timothy M. Johnson,Christopher K. Bichakjian,Andrzej A. Dlugosz +10 more
TL;DR: It is established that concurrent inhibition of multiple pro-survival Bcl-2 proteins leads to effective induction of apoptosis, and strongly support the concept that targeting MCC addiction to these molecules may be useful therapeutically by reversing an intrinsic resistance to cell death.
Journal Article
Prognostic value of immune cell infiltration, tertiary lymphoid structures and PD-L1 expression in Merkel cell carcinomas.
Daniel S Behr,Wiebke K. Peitsch,Christian Hametner,Felix Lasitschka,Roland Houben,Kathrin Schönhaar,Julia Michel,Claudia Dollt,Matthias Goebeler,Alexander Marx,Sergij Goerdt,Astrid Schmieder +11 more
TL;DR: In this paper, the authors showed that the presence of tertiary lymphoid structures (TLS) in the tumor microenvironment significantly correlated with recurrence-free survival (P=0.025).
References
More filters
Journal ArticleDOI
Clonal integration of a polyomavirus in human Merkel cell carcinoma.
TL;DR: In six of eight MCV-positive MCCs, viral DNA was integrated within the tumor genome in a clonal pattern, suggesting that MCV infection and integration preceded clonal expansion of the tumor cells, and MCV may be a contributing factor in the pathogenesis of MCC.
Journal ArticleDOI
Trabecular carcinoma of the skin.
TL;DR: The histological features of these tumors are not sufficiently distinctive to permit differentiation from anaplastic metastatic carcinomas, and familiarity with their existence is of importance in the evaluation of cutaneous malignancy.
Journal ArticleDOI
Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features
Michelle L. Heath,Natalia Jaimes,Bianca D. Lemos,Arash Mostaghimi,Linda Jade Wang,Pablo F. Peñas,Paul Nghiem,Paul Nghiem,Paul Nghiem +8 more
TL;DR: The most significant features can be summarized in an acronym: AEIOU (asymptomatic/lack of tenderness, expanding rapidly, immune suppression, older than 50 years, and ultraviolet-exposed site on a person with fair skin) and 89% of primary MCCs had 3 or more of these findings.
Journal ArticleDOI
Merkel Cell Carcinoma: Prognosis and Treatment of Patients From a Single Institution
Peter J. Allen,Wilbur B. Bowne,David P. Jaques,Murray F. Brennan,Klaus J. Busam,Daniel G. Coit +5 more
TL;DR: The data demonstrate that the natural history of MCC is variable and dependent on the stage of disease at presentation, and pathologic nodal staging identifies a group of patients with excellent long-term survival.
Related Papers (5)
Clonal integration of a polyomavirus in human Merkel cell carcinoma.
Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: Analysis of 5823 cases as the basis of the first consensus staging system
Bianca D. Lemos,Barry E. Storer,Jayasri G. Iyer,Jerri Linn Phillips,Christopher K. Bichakjian,L. Christine Fang,Timothy M. Johnson,Nanette J. Liegeois-Kwon,Clark C. Otley,Kelly G. Paulson,Merrick I. Ross,Siegrid S. Yu,Nathalie C. Zeitouni,David R. Byrd,David R. Byrd,Vernon K. Sondak,Jeffrey E. Gershenwald,Arthur J. Sober,Paul Nghiem,Paul Nghiem,Paul Nghiem +20 more