Journal ArticleDOI
Metabolic physiology in age related macular degeneration.
Reads0
Chats0
TLDR
The basic features of AMD, drusen, choroidal ischemia, and vitreoretinal adhesion are independently determined by genetics and environment and may combine in variable proportions, but they may combine to do so.Citations
More filters
Journal ArticleDOI
Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors
TL;DR: It is imperative that researchers tease out the various contributions of such factors to AMD development but also the connections between AMD and CVD to develop optimal precision medical care for aging adults.
Journal ArticleDOI
Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases
Nicolás Cuenca,Laura Fernández-Sánchez,Laura Campello,Victoria Maneu,Pedro de la Villa,Pedro Lax,Isabel Pinilla +6 more
TL;DR: An overview of the common and distinctive features of retinal neurodegenerative diseases, including the molecular, anatomical and functional changes caused by the cellular response to damage, are provided in order to establish appropriate treatments for these pathologies.
Journal ArticleDOI
OCT angiography and evaluation of the choroid and choroidal vascular disorders.
TL;DR: A review of the salient histological and anatomical features of the choroid, essential for the proper interpretation of in vivo imaging, is followed by a discussion of the fundamental principles of OCTA and the application of this advanced imaging modality to study and understand the Choroid.
Journal ArticleDOI
Molecular mechanisms of retinal pigment epithelium damage and development of age‐related macular degeneration
TL;DR: This review discusses thoroughly RPE‐derived mechanisms in AMD pathology, and specific degenerative findings for AMD are accumulation of intracellular lysosomal lipofuscin and extracellular drusens.
Journal ArticleDOI
The Expanding Role of Vascular Endothelial Growth Factor Inhibitors in Ophthalmology
TL;DR: Patients experiencing adverse events that may be related to VEGF suppression should be carefully evaluated by both the ophthalmologist and the medical physician to reassess the need for intraocular therapy and explore the feasibility of changing medications.
References
More filters
Journal ArticleDOI
Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia
TL;DR: A 28-base pair element in the 5′ promoter that mediates hypoxia-inducible transcription in transient expression assays is identified and sequence motifs in the 3′-untranslated region that may mediate VEGF mRNA stability are revealed.
Journal ArticleDOI
The epidemiology of age-related macular degeneration ☆
TL;DR: The available evidence supports at least a doubling of risk of late AMD associated with long-term smoking, a factor that is under the control of the individual, and racial and ethnic factors are high priorities for further research.
Journal ArticleDOI
Post-transcriptional Regulation of Vascular Endothelial Growth Factor by Hypoxia
TL;DR: A significant post-transcriptional component to the regulation of VEGF is demonstrated, which demonstrates a discrepancy between the transcription rate and the steady-state mRNA level induced by hypoxia.
Journal Article
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.
TL;DR: It is shown that genes regulating cell death can be hypoxically induced and are overexpressed in clinical tumors and that BNIP3 is up-regulated in perinecrotic regions of the tumor.
Journal ArticleDOI
Hypoxic Regulation of Vascular Endothelial Growth Factor in Retinal Cells
TL;DR: Hypoxia increases V EGF expression in retinal cells, which promotes retinal endothelial cell proliferation, suggesting that VEGF plays a major role in mediating intraocular neovascularization resulting from ischemic retinal diseases.