Journal ArticleDOI
Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases
Nicolás Cuenca,Laura Fernández-Sánchez,Laura Campello,Victoria Maneu,Pedro de la Villa,Pedro Lax,Isabel Pinilla +6 more
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TLDR
An overview of the common and distinctive features of retinal neurodegenerative diseases, including the molecular, anatomical and functional changes caused by the cellular response to damage, are provided in order to establish appropriate treatments for these pathologies.About:
This article is published in Progress in Retinal and Eye Research.The article was published on 2014-11-01. It has received 328 citations till now. The article focuses on the topics: Retinal degeneration & Retinal pigment epithelium.read more
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Glia–neuron interactions in the mammalian retina
TL;DR: This review summarizes the main functional relationships between retinal glial cells and neurons, presenting a general picture of the retina recently modified based on experimental observations.
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Role of Inflammation in Diabetic Retinopathy
TL;DR: This review focuses on the involvement of inflammation in the pathophysiology of diabetic retinopathy with special emphasis on the functional relationships between glial cells and neurons, and summarizes recent advances using novel targets to inhibit inflammation.
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The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma
Ana I. Ramírez,Rosa de Hoz,Elena Salobrar-García,Juan J. Salazar,Blanca Rojas,Daniel Ajoy,Inés López-Cuenca,Pilar Rojas,Pilar Rojas,Alberto Triviño,José Ramírez +10 more
TL;DR: The aim of the present review is to describe the contribution in retina to microglial-mediated neuroinflammation in AD, PD, and glaucomatous neurodegeneration.
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Molecular genetics and emerging therapies for retinitis pigmentosa: Basic research and clinical perspectives
Marina França Dias,Kwangsic Joo,Jessica A. Kemp,Sílvia Ligório Fialho,Armando da Silva Cunha,Se Joon Woo,Se Joon Woo,Young Jik Kwon +7 more
TL;DR: Development in gene editing technology and novel gene delivery carriers make gene therapy a promising therapeutic modality for RP and other hereditary retinal dystrophies in the future.
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Retinal remodeling in human retinitis pigmentosa.
Bryan W. Jones,Rebecca L. Pfeiffer,William D. Ferrell,Carl B. Watt,Michael F. Marmor,Robert E. Marc +5 more
TL;DR: The results suggest interventions that presume substantial preservation of the neural retina will likely fail in late stages of the disease, and suggest fundamental work in the biology and mechanisms of disease progression are needed to support vision rescue strategies.
References
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Journal ArticleDOI
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
TL;DR: Induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions is demonstrated and iPS cells, designated iPS, exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka +6 more
TL;DR: It is demonstrated that iPS cells can be generated from adult human fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc.
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Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Junying Yu,Maxim A. Vodyanik,Kim Smuga-Otto,Jessica Antosiewicz-Bourget,Jennifer L. Frane,Shulan Tian,Jeff Nie,Gudrun A. Jonsdottir,Victor Ruotti,Ron Stewart,Igor I. Slukvin,James A. Thomson +11 more
TL;DR: This article showed that OCT4, SOX2, NANOG, and LIN28 factors are sufficient to reprogram human somatic cells to pluripotent stem cells that exhibit the essential characteristics of embryonic stem (ES) cells.
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Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo
TL;DR: Using in vivo two-photon imaging in neocortex, it is found that microglial cells are highly active in their presumed resting state, continually surveying their microenvironment with extremely motile processes and protrusions.
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Microglia: a sensor for pathological events in the CNS
TL;DR: An understanding of intercellular signalling pathways for microglia proliferation and activation could form a rational basis for targeted intervention on glial reactions to injuries in the CNS.