Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis.
Wan-Ling Wong,Xinyi Su,Xiang Li,Chui Ming Gemmy Cheung,Ronald Klein,Ching-Yu Cheng,Tien Yin Wong +6 more
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TLDR
In this article, the authors did a systematic literature review to identify all population-based studies of age-related macular degeneration published before May, 2013, using retinal photographs and standardised grading classifications.Citations
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Identifying Medical Diagnoses and Treatable Diseases by Image-Based Deep Learning
Daniel S. Kermany,Daniel S. Kermany,Michael H. Goldbaum,Wenjia Cai,Carolina C. S. Valentim,Huiying Liang,Sally L. Baxter,Alex McKeown,Ge Yang,Xiaokang Wu,Fangbing Yan,Justin Dong,Made K. Prasadha,Jacqueline Pei,Jacqueline Pei,Magdalene Yin Lin Ting,Jie Zhu,Christina Li,Sierra Hewett,Sierra Hewett,Jason Dong,Ian Ziyar,Alexander Shi,Runze Zhang,Lianghong Zheng,Rui Hou,William Shi,Xin Fu,Xin Fu,Yaou Duan,Viet Anh Nguyen Huu,Viet Anh Nguyen Huu,Cindy Wen,Edward Zhang,Edward Zhang,Charlotte Zhang,Charlotte Zhang,Oulan Li,Oulan Li,Xiaobo Wang,Michael A Singer,Xiaodong Sun,Jie Xu,Ali Tafreshi,M. Anthony Lewis,Huimin Xia,Kang Zhang +46 more
TL;DR: A diagnostic tool based on a deep-learning framework for the screening of patients with common treatable blinding retinal diseases, which demonstrates performance comparable to that of human experts in classifying age-related macular degeneration and diabetic macular edema.
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Global Causes of Blindness and Distance Vision Impairment 1990-2020: A Systematic Review and Meta-Analysis
Seth Flaxman,Rupert R A Bourne,Serge Resnikoff,Serge Resnikoff,Peter Ackland,Tasanee Braithwaite,Maria V Cicinelli,Aditi Das,Jost B. Jonas,Jill E Keeffe,John H. Kempen,Janet L Leasher,Hans Limburg,Kovin Naidoo,Kovin Naidoo,Konrad Pesudovs,Alexander J Silvester,Gretchen A Stevens,Nina Tahhan,Nina Tahhan,Tien Yin Wong,Hugh R. Taylor,Rupert R A Bourne,Aries Arditi,Yaniv Barkana,Banu Bozkurt,Alain M. Bron,Donald L. Budenz,Feng Cai,Robert J Casson,Usha Chakravarthy,Jaewan Choi,Maria Vittoria Cicinelli,Nathan Congdon,Reza Dana,Rakhi Dandona,Lalit Dandona,Iva Dekaris,Monte A. Del Monte,Jenny deva,Laura E. Dreer,Leon B. Ellwein,Marcela Frazier,Kevin D. Frick,David S. Friedman,João M. Furtado,H. Gao,Gus Gazzard,Ronnie George,Stephen Gichuhi,Victor H. Gonzalez,Billy R. Hammond,Mary Elizabeth Hartnett,Minguang He,James F. Hejtmancik,Flavio E. Hirai,John J Huang,April D. Ingram,Jonathan C. Javitt,Jost B. Jonas,Charlotte E. Joslin,John H Kempen,Moncef Khairallah,Rohit C Khanna,Judy E. Kim,George N. Lambrou,Van C. Lansingh,Paolo Lanzetta,Jennifer I. Lim,Kaweh Mansouri,Anu A. Mathew,Alan R. Morse,Beatriz Munoz,David C. Musch,Vinay Nangia,Maria Palaiou,Maurizio Battaglia Parodi,Fernando Yaacov Pena,Tunde Peto,Harry A. Quigley,Murugesan Raju,Pradeep Y. Ramulu,Zane Rankin,Dana Reza,Alan L. Robin,Luca Rossetti,Jinan B. Saaddine,Mya Sandar,Janet B. Serle,Tueng T. Shen,Rajesh K. Shetty,Pamela C. Sieving,Juan Carlos Silva,Rita S. Sitorus,Dwight Stambolian,Gretchen Stevens,Hugh Taylor,Jaime Tejedor,James M. Tielsch,Miltiadis K. Tsilimbaris,Jan C. van Meurs,Rohit Varma,Gianni Virgili,Ya Xing Wang,Ningli Wang,Sheila K. West,Peter Wiedemann,Tien Wong,Richard Wormald,Yingfeng Zheng +109 more
TL;DR: A series of regression models were fitted to estimate the proportion of moderate or severe vision impairment and blindness by cause, age, region, and year, and found that world regions varied markedly in the causes of blindness and vision impairment in this age group.
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A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Lars G. Fritsche,Wilmar Igl,Jessica N. Cooke Bailey,Felix Grassmann,Sebanti Sengupta,Jennifer L. Bragg-Gresham,Kathryn P. Burdon,Scott J. Hebbring,Cindy Wen,Mathias Gorski,Ivana K. Kim,David Cho,Donald J. Zack,Donald J. Zack,Eric H. Souied,Hendrik P. N. Scholl,Hendrik P. N. Scholl,Elisa Bala,Kristine ELee,David J. Hunter,Rebecca J. Sardell,Paul Mitchell,Joanna E. Merriam,Valentina Cipriani,Valentina Cipriani,Joshua D. Hoffman,Tina Schick,Yara T. E. Lechanteur,Robyn H. Guymer,Matthew P. Johnson,Yingda Jiang,Chloe M. Stanton,Gabri'lle H.S. Buitendijk,Xiaowei Zhan,Xiaowei Zhan,Alan M. Kwong,Alexis Boleda,Matthew Brooks,Linn Gieser,Rinki Ratnapriya,Kari Branham,Johanna R. Foerster,John R. Heckenlively,Mohammad Othman,Brendan J. Vote,Helena Liang,Emmanuelle Souzeau,Ian L. McAllister,Timothy Isaacs,Janette Hall,Stewart Lake,David A. Mackey,David A. Mackey,David A. Mackey,Ian J. Constable,Jamie E Craig,Terrie Kitchner,Zhenglin Yang,Zhenglin Yang,Zhiguang Su,Hongrong Luo,Daniel Chen,Hong Ouyang,Ken Flagg,Danni Lin,Guanping Mao,Henry Ferreyra,Klaus Stark,Claudia N von Strachwitz,Armin Wolf,Caroline Brandl,G. Rudolph,Matthias Olden,Margaux A. Morrison,Denise J. Morgan,Matthew Schu,Jeeyun Ahn,Giuliana Silvestri,Evangelia E. Tsironi,Kyu Hyung Park,Lindsay A. Farrer,Anton Orlin,Alexander J. Brucker,Mingyao Li,Christine A. Curcio,Saddek Mohand-Sa'd,José-Alain Sahel,Isabelle Audo,Mustapha Benchaboune,Angela J. Cree,Christina A Rennie,S. V. Goverdhan,Michelle Grunin,Shira Hagbi-Levi,Peter A. Campochiaro,Nicholas Katsanis,Frank G. Holz,Frédéric Blond,Frédéric Blond,Frédéric Blond,Hél'ne Blanché,Jean Fran ois Deleuze,Robert P. Igo,Barbara Truitt,Neal S. Peachey,Neal S. Peachey,Stacy M. Meuer,Chelsea E. Myers,Emily L. Moore,Ronald Klein,Michael A. Hauser,Eric A. Postel,Monique D. Courtenay,Stephen G. Schwartz,Jaclyn L. Kovach,William K. Scott,Gerald Liew,Ava Grace Tan,Bamini Gopinath,John C. Merriam,R. Theodore Smith,R. Theodore Smith,Jane C. Khan,Jane C. Khan,Jane C. Khan,Humma Shahid,Humma Shahid,Anthony T. Moore,Anthony T. Moore,Anthony T. Moore,J Allie McGrath,Renee Laux,Milam A. Brantley,Anita Agarwal,Lebriz Ersoy,Albert Caramoy,Thomas Langmann,Nicole T.M. Saksens,Eiko Kde Jong,Carel B. Hoyng,Melinda Cain,Andrea J. Richardson,Tammy M. Martin,John Blangero,Daniel E. Weeks,Bal Dhillon,Cornelia M. van Duijn,Kimberly F. Doheny,Jane Romm,Caroline C W Klaver,Caroline Hayward,Michael B. Gorin,Michael L. Klein,Paul N. Baird,Anneke I. den Hollander,Sascha Fauser,John R. WYates,John R. WYates,John R. WYates,Rando Allikmets,Jie Jin Wang,Debra A. Schaumberg,Debra A. Schaumberg,Barbara E.K. Klein,Stephanie A. Hagstrom,Itay Chowers,Andrew J. Lotery,Thierry Léveillard,Thierry Léveillard,Thierry Léveillard,Kang Zhang,Kang Zhang,Murray H. Brilliant,Alex W. Hewitt,Alex W. Hewitt,Alex W. Hewitt,Anand Swaroop,Emily Y. Chew,Margaret A. Pericak-Vance,Margaret M. DeAngelis,Dwight Stambolian,Jonathan L. Haines,Sudha K. Iyengar,Bernhard H. F. Weber,Gon'alo R. Abecasis,Iris M. Heid +185 more
TL;DR: The results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.
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Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study.
TL;DR: Results suggest eye care services contributed to the observed reduction of age-standardised rates of avoidable blindness but not of MSVI, and that the target in an ageing global population was not reached.
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Ten years of anti-vascular endothelial growth factor therapy
TL;DR: The discovery of V EGFA, the successes and challenges in the development of VEGFA inhibitors and the impact of these agents on the treatment of cancers and ophthalmic diseases are discussed.
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Philip J. Rosenfeld,David M. Brown,Jeffrey S. Heier,David S. Boyer,Peter K. Kaiser,Carol Chung,Robert Y. Kim +6 more
TL;DR: Intravitreal administration of ranibizumab for 2 years prevented vision loss and improved mean visual acuity, with low rates of serious adverse events, in patients with minimally classic or occult (with no classic lesions) choroidal neovascularization secondary to age-related macular degeneration.
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David M. Brown,Peter K. Kaiser,Mark Michels,Gisèle Soubrane,Jeffrey S. Heier,Robert Y. Kim,Judy P. Sy,Susan Schneider +7 more
TL;DR: Ranibizumab was superior to verteporfin as intravitreal treatment of predominantly classic neovascular age-related macular degeneration, with low rates of serious ocular adverse events and treatment improved visual acuity on average at 1 year.
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Ernest Nagel,Harold Jeffreys +1 more
TL;DR: In this paper, the authors introduce the concept of direct probabilities, approximate methods and simplifications, and significant importance tests for various complications, including one new parameter, and various complications for frequency definitions and direct methods.
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