Journal ArticleDOI
Metabolism of volatile anasthetics—I
TLDR
The metabolism in vivo of several volatile anesthetics has been determined in the rat and their extent of conversion to 14 CO 2 and urinary metabolities labeled with 14 C or 36 Cl is presented.About:
This article is published in Biochemical Pharmacology.The article was published on 1964-08-01. It has received 100 citations till now. The article focuses on the topics: Anesthetic & Methoxyflurane.read more
Citations
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WHO guidelines for drinking-water quality.
TL;DR: In this paper, the introduction of new water mto old distribution systems was discussed, and the water quality changes-chemical and microbiological studies were carried out by using water distrzbution systems.
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Chloroform toxicity in mice: Correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules
TL;DR: Results suggest that the covalent binding is due to a metabolite of CHCl 3, which is causally related to the tissue necrosis and obtained from autoradiograms showing that the radioactivity is located mainly in the necrotic lesions.
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Evidence for phosgene formation during liver microsomal oxidation of chloroform.
TL;DR: When aerobically incubated with liver microsomes and NADPH, chloroform produces a stable adduct with cysteine as a nucleophilic trapping agent that was identified by thin layer chromatography, gas-liquid chromatography and combined gas chromatography-mass spectrometry as the reaction product of Cysteine with phosgene.
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Chemically induced nephrotoxicity: role of metabolic activation.
TL;DR: Renal xenobiotic metabolism can result in production of electrophiles or free radicals that may covalently bind macromolecules or initiate lipid peroxidation in renal cells due to tubular concentrating and/or secretory mechanisms.
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Metabolic activation of halothane and its covalent binding to liver endoplasmic proteins in vitro.
TL;DR: During anaerobic incubation with NADPH-reduced liver microsomes from phenobarbital pretreated rabbits, 14C-labelled halothane (1 mM) was covalently bound to microsomal proteins at a rate of 2 nmol/mg protein in 30 min (CCl4: 11 nmol/.
References
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Liquid scintillation technique for measuring carbon-14 dioxide activity
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The metabolism of 36Cl-labelled trichloroethylene and tetrachloroethylene in the rat
TL;DR: A scheme is presented which would account for the formation of the known metabolites of both tri- and tetrachloroethylene, which are largely excreted through the lungs although there is an appreciable difference between the rates of excretion of the two compounds.
Journal ArticleDOI
Enzymatic dehalogenation of certain brominated and chlorinated compounds.
TL;DR: The dehalogenation in vivo of brominated aliphatic hydrocarbons such as methyl bromide and bromochloromethane has been demonstrated by recovery of inorganic bromides from blood and urine and protein fractions from liver catalyzed the hydrolysis of these molecules to hydrogen ion, halide ion, and formaldehyde.