Journal ArticleDOI
Micro total analysis system (micro-TAS) in biotechnology.
Sang Jun Lee,Sang Yup Lee +1 more
TLDR
This review aims to describe the present state-of-the-art of microsystems for use in biotechnological research, medicine and diagnostics.Abstract:
Nanobiotechnology raises fascinating possibilities for new analytical assays in various fields such as bioelectronic assembly, biomechanics and sampling techniques, as well as in chips or micromachined devices. Recently, nanotechnology has greatly impacted biotechnological research with its potential applications in smart devices that can operate at the level of molecular manipulation. Micro total analysis system (μ-TAS) offers the potential for highly efficient, simultaneous analysis of a large number of biologically important molecules in genomic, proteomic and metabolic studies. This review aims to describe the present state-of-the-art of microsystems for use in biotechnological research, medicine and diagnostics.read more
Citations
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Micromachining a miniaturized capillary electrophoresis-based chemical analysis system on a chip
TL;DR: Micromachining technology was used to prepare chemical analysis systems on glass chips that utilize electroosmotic pumping to drive fluid flow and electrophoretic separation to distinguish sample components with no moving parts.
Journal ArticleDOI
Recent developments in PDMS surface modification for microfluidic devices
TL;DR: This review will present recent research on surface modifications of PDMS using techniques ranging from metal layer coatings and layer‐by‐layer depositions to dynamic surfactant treatments and the adsorption of amphipathic proteins.
Book ChapterDOI
Micromixing Within Microfluidic Devices
TL;DR: A state-of-art review on microstructured mixing devices and their mixing phenomena is given and the advantages and disadvantages of mixing in a microfluidic environment are discussed.
Journal ArticleDOI
Point-of-care immunotesting: approaching the analytical performance of central laboratory methods.
TL;DR: Significant advances in assay and detection technologies have recently facilitated the introduction of truly quantitative, sophisticated immunoassay methods to POC settings as well, with the analytical performance characteristics approaching those of conventional laboratory assays.
Journal ArticleDOI
Bead-based microfluidic immunoassays: The next generation
Chwee Teck Lim,Yong Zhang +1 more
TL;DR: The encoded microbead is the key in providing multiplexing capability to the assay by allowing multi-analyte analysis, and this principle could be applied to microfluidic immunoassays in order to retain all the advantages of a fluidic device and significantly improve multiplexed capability.
References
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Journal ArticleDOI
Rapid prototyping of microfluidic systems in poly(dimethylsiloxane)
TL;DR: A procedure that makes it possible to design and fabricate microfluidic systems in an elastomeric material poly(dimethylsiloxane) (PDMS) in less than 24 h by fabricating a miniaturized capillary electrophoresis system is described.
Journal ArticleDOI
Micro Total Analysis Systems. 1. Introduction, Theory, and Technology
TL;DR: In this article, the authors present a review of the book.http://www.reviewreviews.com/reviews/book-reviews-of-the-book
Journal ArticleDOI
Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip
TL;DR: In this article, the authors demonstrated a miniaturized system for sample handling and separation using electrophoresis-based separations of amino acids with up to 75,000 theoretical plates in about 15 seconds.
Journal ArticleDOI
Micro total analysis systems. 2. Analytical standard operations and applications.
TL;DR: This second part of the review of microfluidic system preparation will cover a number of standard operations as well as some biological applications of micro total analysis systems.
Journal ArticleDOI
An integrated nanoliter DNA analysis device
Mark A. Burns,Brian N. Johnson,Sundaresh N. Brahmasandra,Kalyan Handique,James R. Webster,Madhavi Krishnan,Timothy S. Sammarco,Piu M. Man,Darren Jones,Dylan Heldsinger,Carlos H. Mastrangelo,David T. Burke +11 more
TL;DR: A device was developed that uses microfabricated fluidic channels, heaters, temperature sensors, and fluorescence detectors to analyze nanoliter-size DNA samples to facilitate the use of DNA analysis in applications such as rapid medical diagnostics and point-of-use agricultural testing.