Journal ArticleDOI
Microfluidics-based diagnostics of infectious diseases in the developing world
Curtis D. Chin,Tassaneewan Laksanasopin,Yuk Kee Cheung,David Steinmiller,Vincent Linder,Hesam Parsa,Jennifer Wang,Hannah Moore,Robert Rouse,Gisele Umviligihozo,Etienne Karita,Lambert Mwambarangwe,Sarah L. Braunstein,Janneke van de Wijgert,Ruben Sahabo,Jessica Justman,Wafaa El-Sadr,Samuel K. Sia +17 more
TLDR
The 'mChip' assay had excellent performance in the diagnosis of HIV using only 1 μl of unprocessed whole blood and an ability to simultaneously diagnose HIV and syphilis with sensitivities and specificities that rival those of reference benchtop assays.Abstract:
Ready access to diagnostic tests that work well under remote field conditions is a major barrier to improving the health of people in the developing world. Here, Curtis Chin and his colleagues have developed a chip-based, microfluidic device and handheld reader for the simultaneous and rapid diagnosis of HIV and syphilis that uses only 1 μl of unprocessed whole blood and that was successfully field tested in Rwanda.read more
Citations
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Journal ArticleDOI
The present and future role of microfluidics in biomedical research
TL;DR: The progress made by lab-on-a-chip microtechnologies in recent years is analyzed, and the clinical and research areas in which they have made the greatest impact are discussed.
Journal ArticleDOI
Commercialization of microfluidic point-of-care diagnostic devices
TL;DR: Current work in commercializing microfluidic technologies is reviewed, with a focus on point-of-care diagnostics applications, and the need to strike a balance between achieving real-world impact with integrated devices versus design of novel single microfluidity components is discussed.
Journal ArticleDOI
Point of care diagnostics: Status and future
TL;DR: This chapter discusses the development of personalized medicine and home testing in the developing world, and some of the strategies used to achieve this goal have not yet been developed.
Journal ArticleDOI
Advances in microfluidic materials, functions, integration, and applications.
TL;DR: The successful demonstration of electrophoresis and electroosmotic pumping in a microfluidic device provided a nonmechanical method for both fluid control and separation, and integration of multiple processes can be highly enabling for many applications.
Journal ArticleDOI
Engineers are from PDMS-land, Biologists are from Polystyrenia
TL;DR: A critical evaluation of the strengths and limitations of PDMS and PS in relation to the advancement and future impact on microfluidic cell-based studies and applications is provided and guidelines for researchers who desire to choose the most suitable material for their application are provided.
References
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Journal ArticleDOI
Microfluidic diagnostic technologies for global public health
Paul Yager,Thayne Edwards,Elain Fu,Kristen Helton,Kjell E. Nelson,Milton R. Tam,Bernhard H. Weigl +6 more
TL;DR: The developing world does not have access to many of the best medical diagnostic technologies; they were designed for air-conditioned laboratories, refrigerated storage of chemicals, constant supply of calibrators and reagents, stable electrical power, highly trained personnel and rapid transportation of samples.
Journal ArticleDOI
Simple telemedicine for developing regions: camera phones and paper-based microfluidic devices for real-time, off-site diagnosis.
Andres W. Martinez,Scott T. Phillips,Emanuel Carrilho,Samuel W. Thomas,Hayat Sindi,George M. Whitesides +5 more
TL;DR: A prototype system for quantifying bioassays and for exchanging the results of the assays digitally with physicians located off-site offers new opportunities for inexpensive monitoring of health, especially in situations that require physicians to travel to patients to obtain diagnostic information that might be obtained more effectively by less valuable personnel.