Microneedle Array Patch Made of Kangfuxin/Chitosan/Fucoidan Complex Enables Full-Thickness Wound Healing
Xixi Yu,CaiXia Wang,Yuanfei Wang,Longhao Li,Xiang Gao,Tingting Zhu,Pugen An,Zhaojian Meng,Wanchun Wang,Tong Wu,Yuanping Hao +10 more
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TLDR
A multifunctional microneedle array patch using a blend of kangfuxin (KFX), chitosan (CS), and fucoidan (FD), named KCFMN, for accelerating full-thickness wound healing was developed and it was shown that the K CFMN patch displayed noticeable antibacterial properties and good cytocompatibility.Abstract:
Skin wound caused by external injury is usually difficult to be cured by conventional topical administration because of its poor drug diffusion across the stratum corneum. It has been recognized that stratum corneum is the major obstacle for transdermal drug delivery. To address this issue, microneedles (MNs) have been developed to penetrate the stratum corneum of the skin and then form micron-sized pores between the epidermis and the dermis layers. As such, biomacromolecule drugs and/or insoluble drug molecules can be allowed for effective transdermal penetration. A multifunctional microneedle array patch that can avoid wound infection and promote tissue remolding has important value for wound healing. Among others, marine polysaccharides have attracted much attention in multifarious biomedical applications due to their excellent (bio)physical and chemical properties. Herein, we developed a microneedle array patch using a blend of kangfuxin (KFX), chitosan (CS), and fucoidan (FD), named KCFMN, for accelerating full-thickness wound healing. The traditional Chinese medicine KFX extracted from Periplaneta americana (PA) has effective bio-functions in promoting wound healing. The macro-/micro-morphology and (bio)physicochemical properties of such composite microneedles were also studied. We showed that the KCFMN patch displayed noticeable antibacterial properties and good cytocompatibility. In particular, the KCFMN patch significantly accelerated the wound healing development in a full-thickness wound in rats by improving the epithelial thickness and collagen deposition. Thus, this versatile KCFMN patch has great prospects as a dressing for full-thickness wound healing.read more
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Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications
Deepak Kulkarni,Fouad Damiri,Satish Rojekar,Mehrukh Zehravi,S. Ramproshad,Dipali M. Dhoke,Shubham Musale,Ashiya A. Mulani,Pranav Modak,Roshani Paradhi,Jyotsna Vitore,Md. Habibur Rahman,Mohammed Berrada,Prabhanjan S. Giram,Simona Cavalu +14 more
TL;DR: This review broadly discusses microneedle’s types, fabrication methods, composition, characterization, applications, recent advancements, and global intellectual scenarios.
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Transdermal drug delivery via microneedles to mediate wound microenvironment.
Ranran Mo,Hao Zhang,Ye Xu,Xiangyi Wu,Shun Wang,Zheng Dong,Yangmin Xia,Dongfeng Zheng,Qian Hui Tan +8 more
TL;DR: In this article , a review of microneedle-based strategies for modulating wound microenvironment via introducing the main characteristics of the wound micro environment and various types of MN-based delivery systems are also discussed.
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A Semi-Interpenetrating Network-Based Microneedle for Rapid Local Anesthesia
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Recent progress in polymeric biomaterials and their potential applications in skin regeneration and wound care management
Nidhi Tiwari,Dr.Dharmendra Kumar,A. M. A. Priyadarshani,Gaurav Jain,Gaurav Mittal,Prashant Kesharwani,Geeta Aggarwal +6 more
TL;DR: In this article , the authors highlight the recent advancement in the field of biopolymeric materials (single or in combination) and the various types of wound dressings used in dermal regeneration and wound management.
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A semi-interpenetrating network-based microneedle for rapid local anesthesia
TL;DR: In this paper , a semi-interpenetrating network is developed using covalently crosslinked methacrylated chondroitin sulfate (CS-MA) in combination with PVP K29/32, which is used to successfully load lidocaine hydrochloride (LIDH) and applied as a microneedle patch for rapid local anesthesia.
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