Mikrobiologische Verwandlung von Thebain in das 14-Hydroxycodeinon mittels einiger Pilze
Kyosuke Tsuda,Toshinobu Asai,Yoshihiro Sato,Tokuji Tanaka,Takemasa Matsuhisa,Hiroko Hasegawa +5 more
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This article is published in Chemical & Pharmaceutical Bulletin.The article was published on 1960-11-25 and is currently open access. It has received 13 citations till now.read more
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Engineering novel biocatalytic routes for production of semisynthetic opiate drugs.
TL;DR: The biotransformation of morphine and codeine to the potent analgesic hydromorphone and the mild analgesic/antitussive hydrocodone, respectively, by recombinant Escherichia coli has been demonstrated and the problems encountered when engineering such a system will be discussed.
Journal ArticleDOI
Microbial degradation of the morphine alkaloids: identification of morphinone as an intermediate in the metabolism of morphine by Pseudomonas putida M10
TL;DR: A strain of Pseudomonas putida was isolated by selective enrichment with morphine that was capable of utilising morphine as a primary source of carbon and energy for growth and was shown to be capable of oxidising morphine and codeine to morphinone and codeinone, respectively.
Journal ArticleDOI
Biological synthesis of the analgesic hydromorphone, an intermediate in the metabolism of morphine, by Pseudomonas putida M10.
A M Hailes,Neil C. Bruce +1 more
TL;DR: The morphine alkaloid hydromorphone (dihydromorphinone) was identified as an intermediary metabolite in the degradation of morphine by Pseudomonas putida M10 and a constitutive NADH-dependent morphinone reductase capable of catalyzing the reduction of the 7,8-unsaturated bond of Morphinone and codeinone, yielding hydrom orphone and hydrocodone, respectively was shown to be present in cell extracts.
Journal ArticleDOI
Identification of transformation products arising from bacterial oxidation of codeine by Streptomyces griseus.
D A Kunz,G S Reddy,A Vatvars +2 more
TL;DR: This is the first report providing structural evidence for the biological formation of 14-hydroxycodeine from codeine and of codeine oxidation by S. griseus.
Journal ArticleDOI
Biotransformations of morphine alkaloids by fungi: n-demethylations, oxidations, and reductions
Vigi Chaudhary,Hannes Leisch,Alena Moudra,Blake Allen,Vincenzo De Luca,D. Phillip Cox,Tomáš Hudlický +6 more
TL;DR: The strain Cunninghamella echinulata proved to be the most effective for demethylations of all of the above compounds, except for morphine.
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Paloma Liras,W. W. Umbreit +1 more