Journal ArticleDOI
Modern Transition-Metal-Catalyzed Carbon–Halogen Bond Formation
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TLDR
This Review provides comprehensive coverage of modern transition metal-catalyzed syntheses of organohalides via a diverse array of mechanisms, and focuses on the seminal stoichiometric organometallic studies which led to the corresponding catalytic processes being realized.Abstract:
The high utility of halogenated organic compounds has prompted the development of a vast number of transformations which install the carbon–halogen motif. Traditional routes to these building blocks have commonly involved multiple steps, harsh reaction conditions, and the use of stoichiometric and/or toxic reagents. In this regard, using transition metals to catalyze the synthesis of organohalides has become a mature field in itself, and applying these technologies has allowed for a decrease in the production of waste, higher levels of regio- and stereoselectivity, and the ability to produce enantioenriched target compounds. Furthermore, transition metals offer the distinct advantage of possessing a diverse spectrum of mechanistic possibilities which translate to the capability to apply new substrate classes and afford novel and difficult-to-access structures. This Review provides comprehensive coverage of modern transition metal-catalyzed syntheses of organohalides via a diverse array of mechanisms. Atte...read more
Citations
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Journal ArticleDOI
3d Transition Metals for C-H Activation.
Parthasarathy Gandeepan,Thomas Müller,Daniel Zell,Gianpiero Cera,Svenja Warratz,Lutz Ackermann +5 more
TL;DR: A comprehensive overview on first row transition metal catalysts for C-H activation until summer 2018 is provided.
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Toxicity of Metal Compounds: Knowledge and Myths
TL;DR: In this paper, the authors discuss existing opinions concerning the possibilities of toxicity measurements, high toxicity of heavy-metal compounds, correlation between the structure of a metal compound and its toxicity, biological effect of direct/indirect contacts with metal compounds, and dangers of metal nanoparticles.
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A radical approach to the copper oxidative addition problem: Trifluoromethylation of bromoarenes.
TL;DR: It is demonstrated that this copper oxidative addition problem can be overcome with an aryl radical–capture mechanism, wherein the ariesl radical is generated through a silyl radical halogen abstraction in dual copper-photoredox catalysis.
Journal ArticleDOI
Diverse ortho-C(sp2)–H Functionalization of Benzaldehydes Using Transient Directing Groups
Xi-Hai Liu,Hojoon Park,Jun-Hao Hu,Yan Hu,Qun-Liang Zhang,Bao-Long Wang,Bing Sun,Kap-Sun Yeung,Fang-Lin Zhang,Jin-Quan Yu +9 more
TL;DR: A diverse set of ortho-C(sp2)-H functionalizations of benzaldehyde substrates are reported using the transient directing group strategy, significantly expanding the scope for metal-catalyzed C-H functionalization of benzaldehydes.
Journal ArticleDOI
Development of Halogenase Enzymes for Use in Synthesis
Jonathan Latham,Eileen Brandenburger,Sarah A. Shepherd,Binuraj R. K. Menon,Jason Micklefield +4 more
TL;DR: Advances in developing halogenases forBiocatalysis, potential untapped sources of such biocatalysts and how further optimization of these enzymes is required to achieve the goal of industrial scale biohalogenation are discussed.
References
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