Journal ArticleDOI
Modulation of defensive behavior by periaqueductal gray NMDA/glycine-B receptor.
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TLDR
The present data show that whereas the NMDA/GLY(B) receptor agonists increased the open-arm avoidance responses in the EPM, the antagonists had the opposite effects, suggesting that the dPAG can also participate in more subtle anxiety-like behaviors.About:
This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 2001-12-01. It has received 79 citations till now. The article focuses on the topics: NMDA receptor & Periaqueductal gray.read more
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The neurobiology and control of anxious states
TL;DR: The present article focuses in particular upon the multifarious and complex roles of individual modulators, often as a function of the specific receptor type and neuronal substrate involved in their actions; novel targets for the management of anxiety disorders; the influence of neurotransmitters and other agents upon performance in the VCT; data acquired from complementary pharmacological and genetic strategies and, finally, several open questions likely to orientate future experimental- and clinical-research.
Journal ArticleDOI
Ethological and temporal analyses of anxiety-like behavior: the elevated plus-maze model 20 years on.
TL;DR: In this paper, the authors present a review of the use of the EPM as a post-hoc test to evaluate emotionality in genetically modified rodents and identify and control of major sources of variability in this test.
Journal Article
Current diagnosis and treatment of anxiety disorders.
TL;DR: This work has suggested that additional treatment enhancements should include the development of algorithms that can be easily used in primary care and with greater focus on managing functional impairment in patients with anxiety.
Journal ArticleDOI
Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration.
TL;DR: It is shown that memantine inhibits and reverses the PP‐2A inhibition‐induced abnormal hyperphosphorylation of tau/neurofibrillary degeneration and that this drug might be useful for the treatment of AD and related tauopathies.
Journal ArticleDOI
TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies.
Angelika Erhardt,L. Czibere,D. Roeske,Susanne Lucae,Paul G. Unschuld,Stephan Ripke,Michael Specht,Martin A. Kohli,Stefan Kloiber,Marcus Ising,Angela Heck,Hildegard Pfister,Petra Zimmermann,Roselind Lieb,Benno Pütz,Manfred Uhr,Peter Weber,Jan M. Deussing,Mariya Gonik,Mirjam Bunck,Melanie S. Kessler,Elisabeth Frank,Christa Hohoff,Katharina Domschke,Petra Krakowitzky,Wolfgang Maier,Borwin Bandelow,Christian Jacob,Jürgen Deckert,Stefan Schreiber,Jana Strohmaier,Markus M. Nöthen,Sven Cichon,M. Rietschel,Thomas Bettecken,Martin E. Keck,Rainer Landgraf,Bertram Müller-Myhsok,Florian Holsboer,Elisabeth B. Binder +39 more
TL;DR: Using a mouse model of extremes in trait anxiety, it is shown that anxiety-related behavior was positively correlated with Tmem132d mRNA expression in the anterior cingulate cortex, central to the processing of anxiety/fear-related stimuli, and that in this animal model a T Mem132d SNP is associated with anxiety- related behavior in an F2 panel.
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The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat.
TL;DR: A novel test for the selective identification of anxiolytic and anxiogenic drug effects in the rat is described, using an elevated + -maze consisting of two open arms and two enclosed arms, which showed that behaviour on the maze was not clearly correlated either with exploratory head-dipping or spontaneous locomotor activity.
Journal ArticleDOI
Précis of The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-Hippocampal System..
TL;DR: It is proposed that these drugs reduce anxiety by impairing the functioning of a widespread neural system including the septo-hippocampal system (SHS), the Papez circuit, the prefrontal cortex, and ascending monoaminergic and cholinergic pathways which innervate these forebrain structures.
Book
The rat nervous system
TL;DR: The present work focuses on the development of brain Stem Systems Involved in the Blink Reflex, Feeding Mechanisms, and Micturition of the Spinal Cord, which are involved in the selection of somatic and emotional components of the Motor System in Mammals.
Journal Article
The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.