Modulatory Effects of Mushrooms on the Inflammatory Signaling Pathways and Pro-inflammatory Mediators
Adekunle Babajide Rowaiye,Olobayotan Ifeyomi Wilfred,Olukemi Adejoke Onuh,Doofan Bur,Solomon Oni,Ezinne Janefrances Nwonu,Gordon C. Ibeanu,Angus Nnamdi Oli,Timipanipiri ThankGod Wood +8 more
TLDR
In this paper , the authors reviewed the inhibitory effects of mushrooms on the inflammation process through the modulation of the pro-inflammatory mediators and associated signaling pathways, which leads to the inhibition of inflammation in various types of immune cells and animal models.Abstract:
Mushrooms include a wide variety of bioactive compounds that have been linked to therapeutic and nutritional benefits, making them a potential source of new medications and functional foods. The goal of this study is to offer a complete overview of the mushroom's modulatory effects on inflammatory signaling pathways, which leads to the inhibition of inflammation in various types of immune cells and animal models. This study reviewed the inhibitory effects of mushrooms on the inflammation process through the modulation of the pro-inflammatory mediators and associated signaling pathways. A literature search in PubMed and Google Scholar was conducted for the relevant original research and review articles on the anti-inflammatory effects of mushrooms. Related articles published in English were selected, studied and discussed. As revealed by the selected articles, bioactive molecules which include peptides, polysaccharides, terpenes, sterols, fatty acids, and phenols have been extracted from the powder, concentrate, and different solvent extracts of edible mushrooms. These bioactive molecules have shown significant efficacy in inhibiting the major pro-inflammatory biomarkers and associated pathways in in vivo and in vitro settings. This review demonstrated that mushrooms significantly inhibit the production of pro-inflammatory mediators and can be developed for clinical use as anti-inflammatory agents. Further research is required to establish the comparative efficacy between mushrooms and NSAID especially in the in vivo inhibitory activity against the production of cyclooxygenase and pro-inflammatory cytokines. read more
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Mushrooms as future generation healthy foods
TL;DR: The potential of mushrooms as antiviral, anti-inflammatory, antineoplastic, and other health concerns is discussed in this paper , where the authors highlight the potential of edible mushrooms as an unexploited treasure trove, although rarely included in known food guidelines.
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Cognitive Healthy Aging in Mice: Boosting Memory by an Ergothioneine-Rich Hericium erinaceus Primordium Extract
Elisa Roda,Fabrizio De Luca,Daniela Ratto,Erica Cecilia Priori,Elena Savino,Maria Grazia Bottone,Paola Rossi +6 more
TL;DR: In this paper , the ERGO-rich He primordium extract (He2) was shown to have a selective, preventive and neuroprotective effect on aged hippocampus, both on recognition memory as well on inflammation/oxidative stress/glutamate receptors expression.
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Terfezia boudieri and Terfezia claveryi inhibit the LPS/IFN-γ-mediated inflammation in RAW 264.7 macrophages through an Nrf2-independent mechanism
TL;DR: In this paper , the anti-inflammatory properties of truffle extracts were investigated in RAW 264.7 macrophages and two main truffles, Terfezia boudieri and T. claveryi, were found to reduce the production of nitric oxide and inhibit the expression of various pro-inflammatory markers.
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Emergency Protective Measures and Strategies of COVID-19: From Lifestyle to Traditional Chinese Medicine
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Book ChapterDOI
Potential of Medicinal Mushrooms in Human Health and Welfare: An Overview
TL;DR: In this paper , the authors summarized the knowledge on biomolecules of mushrooms in human health and highlighted their healing traits against major lifestyle-related diseases, and revealed the capacity of these bioactive metabolites in developing innovative functional food products with pharmaceutical potential.
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