Molecular basis for ADP-induced platelet activation, I : Evidence for three distinct ADP receptors on human platelets
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TLDR
Results clearly demonstrate the presence of two distinct platelet ADP receptors in addition to the P2X receptor: one coupled to adenylyl cyclase and the other coupled to mobilization of calcium from intracellular stores through inositol trisphosphates.About:
This article is published in Journal of Biological Chemistry.The article was published on 1998-01-23 and is currently open access. It has received 467 citations till now. The article focuses on the topics: Platelet activation & Thromboxane A2.read more
Citations
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Book ChapterDOI
Receptors for Purines and Pyrimidines
Vera Ralevic,Geoffrey Burnstock +1 more
TL;DR: In this review particular emphasis is placed on the discrepancy between the concentrations ofadenosine, ADP, and ATP in the purine receptors of UDP and UTP.
Journal ArticleDOI
Identification of the platelet ADP receptor targeted by antithrombotic drugs.
Gunther Hollopeter,Hans-Michael Jantzen,Diana Vincent,Georgia Li,Laura J. England,Vanitha Ramakrishnan,Ruey-Bing Yang,Paquita Nurden,Alan T. Nurden,David Julius,Pamela B. Conley +10 more
TL;DR: The cloning of this receptor, designated P2Y12, is described and evidence that a patient with a bleeding disorder has a defect in this gene is provided, which should facilitate the development of better antiplatelet agents to treat cardiovascular diseases.
Journal ArticleDOI
International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy
Maria P. Abbracchio,Geoffrey Burnstock,Jean-Marie Boeynaems,Eric A. Barnard,José L. Boyer,Charles Kennedy,Gillian E. Knight,Marta Fumagalli,Christian Gachet,Kenneth A. Jacobson,Gary A. Weisman +10 more
TL;DR: There have been many advances in knowledge about different aspects of P2Y receptor signaling since the last review published by the International Union of Pharmacology subcommittee, and more receptor subtypes have been cloned and characterized and most orphan receptors deorphanized, so that it is now possible to provide a basis for a future subdivision of P 2Y receptor sub types.
Journal ArticleDOI
Cellular distribution and functions of P2 receptor subtypes in different systems.
TL;DR: This review is aimed at providing readers with a comprehensive reference article about the distribution and function of P2 receptors in all the organs, tissues, and cells in the body.
Journal ArticleDOI
Nucleotide receptors: an emerging family of regulatory molecules in blood cells.
Francesco Di Virgilio,Paola Chiozzi,Davide Ferrari,Simonetta Falzoni,Juana M. Sanz,Anna Morelli,Maurizia Torboli,Giorgio Bolognesi,O. Roberto Baricordi +8 more
TL;DR: During inflammation or vascular damage, nucleotides may provide an important mechanism involved in the activation of leukocytes and platelets.
References
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Journal ArticleDOI
A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
Gray D. Shaw,Robert Kamen +1 more
TL;DR: It is proposed that the AU sequences are the recognition signal for an mRNA processing pathway which specifically degrades the mRNAs for certain lymphokines, cytokines, and proto-oncogenes.
Journal ArticleDOI
Inositol phosphates and cell signalling
TL;DR: The subtlety of calcium regulation by inositol phosphates is emphasized by recent studies that have revealed oscillations in calcium concentration which are perhaps part of a frequency-encoded second-messenger system.
Journal Article
Nomenclature and classification of purinoceptors
Bertil B. Fredholm,Maria P. Abbracchio,Geoffrey Burnstock,J. W. Daly,T K Harden,Kenneth A. Jacobson,P Leff,Michael Williams +7 more
TL;DR: The evidence is now compelling that ATP plays important physiological and/ or pathophysiological roles in a variety of biological systems, and the presence of receptors for ADP and adenosine (presumably A2) receptors exist on platelets is compelling.
Journal ArticleDOI
Is there a basis for distinguishing two types of P2-purinoceptor?
TL;DR: Differences in the structure of the P2-purinoceptor in various tissues may be useful in the development of drugs for the treatment of vascular, gastrointestinal and urinoglenital disorders.
Journal ArticleDOI
Adenosine Diphosphate in Red Cells as a Factor in the Adhesiveness of Human Blood Platelets
TL;DR: Adenosine Diphosphate in Red Cells as a Factor in the Adhesiveness of Human Blood Platelets and the Adhesion of Human blood Platelets is studied.
Related Papers (5)
Molecular Basis for ADP-induced Platelet Activation II. THE P2Y1 RECEPTOR MEDIATES ADP-INDUCED INTRACELLULAR CALCIUM MOBILIZATION AND SHAPE CHANGE IN PLATELETS
Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation
Jianguo Jin,Satya P. Kunapuli +1 more