Journal ArticleDOI
Molecular profiling--a tool for addressing emerging gaps in the comparative risk assessment of GMOs.
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TLDR
The literature-based discussions on the use of profiling appear to have settled on two findings: 1. profiling techniques are reliable and relevant, at least no less so than other techniques used in risk assessment; and 2. although not required routinely, regulators should be aware of when they are needed.About:
This article is published in Environment International.The article was published on 2011-10-01. It has received 49 citations till now. The article focuses on the topics: Risk assessment & Profiling (information science).read more
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Journal ArticleDOI
A comparative evaluation of the regulation of GM crops or products containing dsRNA and suggested improvements to risk assessments.
TL;DR: Risk assessment advice offered to government regulators in Australia, New Zealand and Brazil during official risk evaluations of GM plants for use as human food or for release into the environment is documented, and what that experience teaches us about the GMO risk assessment framework is suggested.
Journal ArticleDOI
An integrated multi-omics analysis of the NK603 Roundup-tolerant GM maize reveals metabolism disturbances caused by the transformation process.
Robin Mesnage,Sarah Zanon Agapito-Tenfen,Vinicius Vilperte,George Renney,Malcolm Ward,Gilles-Eric Séralini,Rubens Onofre Nodari,Michael Antoniou +7 more
TL;DR: Proteome profiles of the maize kernels revealed alterations in the levels of enzymes of glycolysis and TCA cycle pathways, which were reflective of an imbalance in energy metabolism.
Journal ArticleDOI
Revisiting risk governance of GM plants: the need to consider new and emerging gene-editing techniques
Sarah Zanon Agapito-Tenfen,Arinze S. Okoli,Michael J. Bernstein,Odd Gunnar Wikmark,Anne Ingeborg Myhr +4 more
TL;DR: A process informed by responsible research and innovation practices, involving a broader community of people, organizations, experts, and interest groups, could help scientists, regulators, and other stakeholders address complex, value-laden concerns related to gene-editing of plants with and for society.
Journal ArticleDOI
Molecular profiling of marine fauna: integration of omics with environmental assessment of the world's oceans.
TL;DR: The current review highlights recent examples of the biological information obtained for marine sentinel teleosts, mammals, and invertebrates that can provide a systems biology framework in the detection and evaluation of environmental chemical contaminant effects on marine fauna.
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Effect of stacking insecticidal cry and herbicide tolerance epsps transgenes on transgenic maize proteome
Sarah Zanon Agapito-Tenfen,Vinicius Vilperte,Rafael Fonseca Benevenuto,Carina Macagnan Rover,Terje Traavik,Rubens Onofre Nodari +5 more
TL;DR: The first results of a proteomic profiling coupled to transgene transcript expression analysis of a stacked commercial maize hybrid containing insecticidal and herbicide tolerant traits in comparison to the single event hybrids in the same genetic background are reported.
References
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Journal ArticleDOI
Integrated genomic and proteomic analyses of a systematically perturbed metabolic network.
Trey Ideker,Vesteinn Thorsson,Jeffrey A. Ranish,Rowan H. Christmas,Jeremy Buhler,Jimmy K. Eng,Roger E. Bumgarner,David R. Goodlett,Ruedi Aebersold,Leroy Hood +9 more
TL;DR: An integrated approach to build, test, and refine a model of a cellular pathway, in which perturbations to critical pathway components are analyzed using DNA microarrays, quantitative proteomics, and databases of known physical interactions, suggests hypotheses about the regulation of galactose utilization and physical interactions between this and a variety of other metabolic pathways.
Journal ArticleDOI
Control of coleopteran insect pests through RNA interference
James A. Baum,Thierry Bogaert,William P. Clinton,Gregory R. Heck,Pascale Feldmann,Oliver Ilagan,Scott N. Johnson,Geert Plaetinck,Tichafa R. I. Munyikwa,Michael Pleau,Ty T. Vaughn,James K. Roberts +11 more
TL;DR: It is demonstrated that ingestion of double-stranded (ds)RNAs supplied in an artificial diet triggers RNA interference in several coleopteran species, most notably the western corn rootworm Diabrotica virgifera virgifiera LeConte, suggesting that the RNAi pathway can be exploited to control insect pests via in planta expression of a dsRNA.
Journal ArticleDOI
Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypol
Ying-Bo Mao,Wen-Juan Cai,Jiawei Wang,Gao-Jie Hong,Xiaoyuan Tao,Ling-Jian Wang,Yongping Huang,Xiao-Ya Chen +7 more
TL;DR: A cytochrome P450 gene (CYP6AE14) is identified from cotton bollworm, which permits this herbivore to tolerate otherwise inhibitory concentrations of the cotton metabolite, gossypol, and its expression correlates with larval growth when gOSSypol is included in the diet.
Journal ArticleDOI
Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution
Brian T. Wilhelm,Brian T. Wilhelm,Samuel Marguerat,Samuel Marguerat,Stephen Watt,Stephen Watt,Falk Schubert,Falk Schubert,Valerie Wood,Ian Goodhead,Ian Goodhead,Christopher J. Penkett,Christopher J. Penkett,Jane Rogers,Jürg Bähler,Jürg Bähler +15 more
TL;DR: High-throughput sequencing of complementary DNAs (RNA-Seq) and strand-specific array data provide rich condition-specific information on novel, mostly non-coding transcripts, untranslated regions and gene structures, thus improving the existing genome annotation.
Journal ArticleDOI
Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity.
Aimee L. Jackson,Julja Burchard,Janell M. Schelter,B. Nelson Chau,Michele A. Cleary,Lee Lim,Peter S. Linsley +6 more
TL;DR: In all cases, off-target transcript silencing was accompanied by loss of the corresponding protein and occurred with dependence on siRNA concentration similar to that of silencing of the target transcript.