Journal ArticleDOI
Monoclonal antibodies to human trophoblast and sperm antigens: report of two WHO-sponsored workshops, June 30, 1986--Toronto, Canada.
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TLDR
Two WHO-sponsored workshops were recently held to obtain a consensus view from researchers active in the field of reproductive immunology on the current status of the application of monoclonal antibodies to studies of molecular events underlying reproduction and to determine the feasibility of using this approach to identify trophoblast- or sperm-specific antigens that might represent suitable candidates for the development of antifertility vaccines.About:
This article is published in Journal of Reproductive Immunology.The article was published on 1987-03-01. It has received 168 citations till now. The article focuses on the topics: Monoclonal antibody.read more
Citations
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Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre‐eclamptic pregnancies
TL;DR: Whether syncytiotrophoblast microvilli are shed into the maternal circulation in increased amounts in pre‐eclamptic pregnancies as a possible cause of maternal vascular endothelial dysfunction is investigated.
Journal ArticleDOI
The biologic significance of white blood cells in semen.
Edward E. Wallach,Hans Wolff +1 more
TL;DR: There is ample evidence that WBC can affect sperm function and further studies are needed to define cofactors that increase or decrease the risk of sperm damage by WBC.
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In vitro systems for the study of human placental endocrine function.
G.E. Ringler,Jerome F. Strauss +1 more
TL;DR: The purpose is to review the existing in vitro systems for study of endocrine functions of human placental function as well as the biology of secretory cells in general.
Journal ArticleDOI
Isolation of fetal trophoblast cells from peripheral blood of pregnant women
U. W. Mueller,C.S. Hawes,A.E. Wright,E. DeBoni,W.R. Jones,Frank A. Firgaira,Alec Morley,David R. Turner +7 more
TL;DR: The fetal sex predicted by PCR analysis of the isolated trophoblast cells accorded with that ascertained by karyotyping of chorionic villus samples in eleven of twelve women studied in early pregnancy and with the sex of the baby on delivery in one woman studied at 34 weeks' gestation.
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Trophoblast deportation in human pregnancy--its relevance for pre-eclampsia.
TL;DR: In this article, trophoblast deportation may be part of the process by which a circulating factor derived from the placenta enters the maternal circulation, and trophoblasts were enriched using immunomagnetic beads to deplete leucocytes.
References
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Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).
Davor Solter,Barbara B. Knowles +1 more
TL;DR: A monoclonal antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with F9 teratocarcinoma cells is described, which defines an embryonic stage-specific antigen.
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Human trophoblast cell-surface antigens defined by monoclonal antibodies.
TL;DR: Anti-Trop-1 and anti-trop-2 antibodies might prove useful for detection and isolation of fetal trophoblast cells circulating in pregnant women's blood and for diagnosis and therapy in patients having choriocarcinomas and other germ-cell neoplasms.
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Three monoclonal antibodies defining distinct differentiation antigens associated with different high molecular weight polypeptides on the surface of human embryonal carcinoma cells.
TL;DR: The epitopes defined by the present antibodies differ from those recognized by the other human EC cell-specific monoclonal antibodies that have been described and provide new markers for studying the differentiation of pluripotent human EC cells.
Journal Article
Techniques for detection of iso- and auto-antibodies to human spermatozoa.
TL;DR: Techniques for the detection of iso- and autoantibodies to human spermatozoa and potential application of immunologic techniques in the control of fertility and general investigative methods are discussed.
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Antigen expression by trophoblast populations in the human placenta and their possible immunobiological relevance.
TL;DR: Antigen expression by villous and extravillous human trophoblast populations at discrete anatomical sites has been reviewed, and antigenic alterations have been noted in the maternal uterine gland epithelium in pregnancy leading to the expression of a trophoblastic phenotype, thereby suggesting a mechanism of extrinsic regulation of gene expression in these tissues.