Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease
TLDR
One undescribed indole alkaloid together with twenty-two known compounds have been isolated from aerial parts of Vinca minor L. (Apocynaceae) as discussed by the authors .About:
This article is published in Phytochemistry.The article was published on 2022-02-01 and is currently open access. It has received 4 citations till now. The article focuses on the topics: Apocynaceae & Butyrylcholinesterase.read more
Citations
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The Vinca minor genome highlights conserved evolutionary traits in monoterpene indole alkaloid synthesis
Emily Amor Stander,Clément Cuello,Caroline M. C. Birer-Williams,Natalja Kulagina,Hans Jansen,Inês Carqueijeiro,Louis-Valentin Meteignier,Valentin Vergès,Audrey Oudin,Nicolas Papon,Ron P. Dirks,Michael Krogh Jensen,Sarah E. O'Connor,Thomas Dugé de Bernonville,Sébastien Besseau,Vincent Courdavault +15 more
TL;DR: It is expected that access to these resources will facilitate the elucidation of unknown MIA biosynthetic routes with the potential of transferring these pathways to heterologous expression systems for large-scale MIA production.
Journal ArticleDOI
An efficient two-step approach for the preparative separation and purification of eight polyphenols from Hibiscus manihot L. flower with high-speed countercurrent chromatography
TL;DR: A green and efficient ultrasonic-assisted extraction method of polyphenols from Hibiscus manihot L. flowers (HMLF) was performed, and the corresponding experimental parameters were optimized by Taguchi OA Design as discussed by the authors .
Journal ArticleDOI
New indole derivatives as multitarget anti-Alzheimer's agents: synthesis, biological evaluation and molecular dynamics.
Eman M. Azmy,Ibrahim F. Nassar,Mohamed Hagras,Iten M. Fawzy,Maghawry Hegazy,Mahmoud Mokhtar,Amr M. Yehia,Nasser S.M. Ismail +7 more
TL;DR: In this paper , 13 novel "oxathiolanyl", "pyrazolyl" and "pyrimidinyl" derivatives were designed and synthesized as anti-Alzheimer's disease treatment.
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