Journal ArticleDOI
Multicenter study of oxygen-insensitive handheld glucose point-of-care testing in critical care/hospital/ambulatory patients in the United States and Canada
Gerald J. Kost,Huynh Troung Vu,Judith H. Lee,Peggy Bourgeois,Frederick L. Kiechle,Carol Martin,Sam S. Miller,Anthony O. Okorodudu,John J. Podczasy,Robert Webster,Karen J. Whitlow +10 more
TLDR
The performance of GD-based, oxygen-insensitive, handheld glucose testing was technically suitable for arterial specimens in critical care patients, cord blood and heelstick specimens in neonates, and capillary and venous specimens in other patients.Abstract:
ObjectivesExisting handheld glucose meters are glucose oxidase (GO)-based. Oxygen side reactions can introduce oxygen dependency, increase potential error, and limit clinical use. Our primary objectives were to: a) introduce a new glucose dehydrogenase (GD)-based electrochemical biosensor for point-read more
Citations
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A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy
Hyunjae Lee,Tae-Kyu Choi,Young Bum Lee,Hye Rim Cho,Roozbeh Ghaffari,Liu Wang,Hyung Jin Choi,Taek Dong Chung,Nanshu Lu,Taeghwan Hyeon,Seung Hong Choi,Seung Hong Choi,Dae-Hyeong Kim +12 more
TL;DR: G graphene doped with gold and combined with a gold mesh has improved electrochemical activity over bare graphene, sufficient to form a wearable patch for sweat-based diabetes monitoring and feedback therapy and can be thermally actuated to deliver Metformin and reduce blood glucose levels in diabetic mice.
Journal ArticleDOI
Emerging Technologies for Next-Generation Point-of-Care Testing
TL;DR: Considerable advances in point-of-care testing (POCT) devices stem from innovations in cellphone (CP)-based technologies, paper-based assays, lab-on-a-chip platforms, novel assay formats, and strategies for long-term reagent storage.
Journal ArticleDOI
Factors affecting blood glucose monitoring: sources of errors in measurement.
TL;DR: In this review, the measurement of error in blood glucose, the sources of error, and their mechanism and potential solutions to improve accuracy in the hands of the patient are discussed.
Journal ArticleDOI
Effects of Different Hematocrit Levels on Glucose Measurements With Handheld Meters for Point-of-Care Testing
TL;DR: It is strongly recommended that clinical professionals choose glucose systems carefully and interpret glucose measurements with extreme caution when the patient's hematocrit value changes, particularly if there is a simultaneous change in glucose level.
Journal ArticleDOI
Novel electrochemical sensor system for protein using the aptamers in sandwich manner.
TL;DR: In this article, two different aptamers were chosen to construct sandwich type sensing system for protein, and one was immobilized onto the gold electrode for capturing thrombin onto the electrode and the other was used for detection.
References
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Journal ArticleDOI
Ferrocene-mediated enzyme electrode for amperometric determination of glucose.
Anthony E. G. Cass,Graham Davis,Francis Gd,Hugh Allen Oliver Hill,W.J. Aston,I.J. Higgins,E. V. Plotkin,Scott Ld,Anthony Turner +8 more
TL;DR: Type III adenosine deaminase would be the best choice for the construction of an immobilized enzyme electrode both from the point of view of apparent Km and Vmax values and from the less pronounced product inhibition effect on the type III enzyme compared to the Type V enzyme.
Journal ArticleDOI
Evaluating Clinical Accuracy of Systems for Self-Monitoring of Blood Glucose
TL;DR: An error grid analysis (EGA) is developed, which describes the clinical accuracy of SMBG systems over the entire range of blood glucose values, taking into account the absolute value of the system-generated glucose value, the relative difference between these two values, and the clinical significance of this difference.
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The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus.
TL;DR: Long-term intensified insulin treatment, as compared with standard treatment, retards the development of microvascular complications in patients with insulin-dependent diabetes mellitus.
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Design and in vitro studies of a needle-type glucose sensor for subcutaneous monitoring.
Dilbir S. Bindra,Yanan Zhang,George S. Wilson,Robert Sternberg,Daniel R. Thévenot,Dinah. Moatti,Gérard Reach +6 more
TL;DR: A new miniaturized glucose oxidase based needle-type glucose microsensor has been developed for subcutaneous glucose monitoring and exhibits good selectivity against common interferences except for the exogenous drug acetaminophen.
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Glycemic control and sliding scale insulin use in medical inpatients with diabetes mellitus
TL;DR: Although sliding scale insulin regimens are prescribed for the majority of inpatients with diabetes, they appear to provide no benefit; in fact, when used without a standing dose of intermediate-acting insulin, they are associated with an increased rate of hyperglycemic episodes.