Journal ArticleDOI
Multicomponent reactions (MCR) in medicinal chemistry: a patent review (2010-2020).
Hafiza Amna Younus,Mariya al-Rashida,Abdul Hameed,Maliha Uroos,Uzma Salar,Sobia Rana,Khalid Mohammed Khan,Khalid Mohammed Khan +7 more
TLDR
Application of MCRs is the recent advancement in the field of drug design and discovery which will expectedly lead to the development of medicinally important heterocyclic compounds with a vast range of biological activities.Abstract:
Introduction: Multicomponent reactions (MCR) has been utilized to synthesize a vast range of analogs belonging to diverse classes of heterocyclic compounds offering multidimensional pharmaceutical applications. The unique feature of MCR includes the synthesis of highly functionalized molecules in a single pot to build quick libraries of compounds of biological interest to identify new leads as potential therapeutic agents.Area covered: The current review article covers the patents published in the last decade in order to highlight the importance of multicomponent reactions for synthesizing complex-functionalized molecules of high biological significance.Expert opinion: Easily automated one-pot multicomponent reactions (MCRs) has demonstrated successful impact at different stages of the lead discovery, lead optimization, and pre-clinical process development arenas. Application of MCRs is the recent advancement in the field of drug design and discovery which will expectedly lead to the development of medicinally important heterocyclic compounds with a vast range of biological activities.read more
Citations
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Journal ArticleDOI
Recent advances in multi-component reactions and their mechanistic insights: a triennium review
TL;DR: Multi-component reactions (MCRs) are considered to be an important methodological arsenal in synthetic and medicinal chemistry as mentioned in this paper, and they have been strategically employed in various synthetic transformations where classical methods usually involve many steps with tedious procedures.
Journal ArticleDOI
Recent Applications of the Multicomponent Synthesis for Bioactive Pyrazole Derivatives
TL;DR: The present review summarizes the recent developments of multicomponent reactions for the synthesis of biologically active molecules containing the pyrazole moiety and covers the articles published from 2015 to date related to antibacterial, anticancer, antifungal, antioxidant, α-glucosidase and α-amylase inhibitory, anti-inflammatory, antimycobacterial, antimalarial, and miscellaneous activities of pyrazoles obtained exclusively via an MCR.
Journal ArticleDOI
Green one-pot synthesis and in vitro antibacterial screening of pyrano[2,3-c]pyrazoles, 4H-chromenes and pyrazolo[1,5-a]pyrimidines using biocatalyzed pepsin
TL;DR: In this paper , a multicomponent reaction of 4-formylphenyl benzoates, malononitrile, and pyrazolones utilizing pepsin as a biocatalyst was investigated in different reaction conditions.
Journal ArticleDOI
Synthesis, crystal structure and in silico studies of novel 2,4-dimethoxy-tetrahydropyrimido[4,5-b]quinolin-6(7H)-ones
S. G. Patel,Ruturajsinh M. Vala,Paras Patel,Dipti Upadhyay,Venkatachalam Ramkumar,Ramesh L. Gardas,Hiten M. Patel +6 more
TL;DR: In this paper , acetic acid mediated multicomponent synthesis of novel 2,4-dimethoxy-tetrahydropyrimido[4,5-b]quinolin-6(7H)-one (2,4]-THPQs was reported.
Journal ArticleDOI
A new copper Schiff‐base complex of 3,4‐diaminobenzophenone stabilized on magnetic MCM‐41 as a homoselective and reusable catalyst in the synthesis of tetrazoles and pyranopyrazoles
TL;DR: In this paper , a new copper Schiff-base complex of 3,4-diaminobenzophenone was supported on magnetic MCM-41 and was used as a practical and magnetically reusable catalyst.
References
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Chemistry and Biology Of Multicomponent Reactions
TL;DR: This paper presents a new approach to drug design called “combinatorial biosynthesis and drug discovery through nanofiltration”, which combines the efforts of a single investigator with those of a number of other scientists.
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Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity
TL;DR: An overview of general strategies that allow the design of novel multicomponent reactions is presented and the challenges and opportunities for the future are discussed.
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Multicomponent reactions: advanced tools for sustainable organic synthesis
TL;DR: In this article, the utility of multicomponent reactions as methods for green synthesis is highlighted and the practical value of these type of reactions for meeting many of the criteria set by the green chemistry philosophy.
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Heterocyclen aus CH-aciden Nitrilen, VIII. 2-Amino-thiophene aus methylenaktiven Nitrilen, Carbonylverbindungen und Schwefel
TL;DR: In this paper, the Einwirkung von Schwefel auf vinyloge methylenaktive Nitrile, gestattet auch die Einbeziehung von Alkylarylketonen in die Reaktion.
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Multicomponent reactions for the synthesis of pyrroles
TL;DR: Multicomponent reactions are one of the most interesting concepts in modern synthetic chemistry and provide an attractive entry into pyrrole derivatives, which are very important heterocycles from many points of view.