Journal ArticleDOI
Multiple sclerosis in childhood: clinical features of 149 cases.
Angelo Ghezzi,V. Deplano,J. Faroni,Maria Grazia Grasso,Maria Liguori,Giovanni Marrosu,Carlo Pozzilli,Isabella Laura Simone,Mauro Zaffaroni +8 more
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TLDR
In early onset MS patients with disease duration < 8 years, cases with EDSS > 6 were slightly more frequent than in the AOMS group and the frequency of cases for different levels of disability was similar for disease duration > 8 years.Abstract:
From the retrospective study of 3375 patients affected by clinically definite or probable multiple sclerosis (MS), 149 patients were collected with onset of the disease before the age of 16 years (4.4%). Female/male ratio was higher than that of the adult onset MS (AOMS) population (2.2 vs 1.6) particularly at ages of onset after 12 years (3.0, P = 0.007 vs AOMS). Among initial symptoms, those suggesting brainstem dysfunction (25%) were more frequent compared to other systems and compared to AOMs symptoms; motor and sensory disturbances were slightly less frequent (respectively 17.5% and 18.3%). Optic neuritis appeared in 16.5% of cases with onset in childhood and in 16.2% of cases with AOMS, cerebellar disturbances respectively in 9.1% and 7.7%. The first interattack-interval and the clinical course of early onset MS did not differ significantly from AOMS. In early onset MS patients with disease duration 6 were slightly more frequent than in the AOMS group (P = 0.04). The frequency of cases for different levels of disability was similar for disease duration > 8 years.read more
Citations
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Journal ArticleDOI
Gender differences in autoimmune disease.
TL;DR: Gender differences in systemic and organ-specific autoimmune diseases are considered, and human data is summarized that outlines the prevalence of common autoimmune diseases specific to adult males and females in countries commonly surveyed.
Journal ArticleDOI
Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children.
TL;DR: Differences in the presentation of ADEM/MDEM compared with multiple sclerosis may help in the prognosis given to families regarding the possibility of later development of multiple sclerosis.
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Natural history of multiple sclerosis
TL;DR: Primary progressive MS may differ from relapsing-remitting MS in MRI lesion frequency, immunogenetic profile, responsiveness to immunosuppressive treatment, and histology.
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Natural History of Multiple Sclerosis with Childhood Onset
TL;DR: Patients with childhood onset reach these different critical phases of the disease at a younger age than patients with adult onset, therefore contradicting the notion of a more favorable prognosis in this age group.
Journal ArticleDOI
Early onset multiple sclerosis: A longitudinal study
TL;DR: A RR course was seen in the majority of cases of early onset MS, and a high frequency of relapses, early age at permanent disability, and the presence of malignant cases raise the question of possible early use of disease-modifying therapy in patients withEarly onset MS.
References
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Journal ArticleDOI
Rating neurologic impairment in multiple sclerosis An expanded disability status scale (EDSS)
TL;DR: A new Expanded Disability Status Scale (EDSS) is presented, with each of the former steps (1,2,3 … 9) now divided into two (1.0, 1.5, 2.0 … 9).
Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability.
Brian G. Weinshenker,B. Bass,George P.A. Rice,John H. Noseworthy,W. Carriere,J. Baskerville,George C. Ebers +6 more
TL;DR: The outcome of multiple sclerosis, assessed according to the Kurtzke Disability Status Scale, was reviewed in 1,099 consecutive patients followed in London, Canada, between 1972 and 1984 and the rate at which disability develops after the onset of a progressive phase of MS is presented.
Journal ArticleDOI
Prognostic factors in a multiple sclerosis incidence cohort with twenty-five years of follow-up
Björn Runmarker,Oluf Andersen +1 more
TL;DR: In patients with an acute onset, low onset age, high degree of remission at first exacerbation, symptoms from afferent nerve fibres and onset symptoms from only one region (as compared with polyregional symptoms of the central nervous system, were factors significantly associated with a favourable long-term prognosis.
Journal ArticleDOI
Course and Prognosis of Multiple Sclerosis Assessed by the Computerized Data Processing of 349 Patients
TL;DR: The information of 349 cases of multiple sclerosis, seen in a neurological department over a twenty-year period and followed up for a mean of nine years, was analysed by computerized data processing and a disability score and the duration of the disease prognostic factors were studied.