Journal ArticleDOI
Multiple sclerosis: twenty years on low fat diet.
TLDR
The author's experience in treating cases of multiple sclerosis with a low fat diet for more than 20 years is assessed, both in treatment of the data and in conclusions.Abstract:
THIS paper assesses the author's experience in treating cases of multiple sclerosis with a low fat diet for more than 20 years. Previous reports of these studies 1-5 were preliminary in intent. The present paper is intended to be final, both in treatment of the data and in conclusions. Materials and Methods Patient Material.— Evaluation and discussion of the materials and methods were presented in detail in a previous paper. 4 The more pertinent points, however, will be included here. From December 1948 to April 1954, 264 patients with multiple sclerosis were examined at the Montreal Neurological Institute; 108 were seen only a few times. The remaining 156 patients maintained contact to and beyond April 1954, and no patients were added after this date. Two were rejected because of uncertain diagnosis, and eight were lost during the ensuing years. The remaining 146 patients are included in this report ofread more
Citations
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Book ChapterDOI
Fatty Acids and Immunity
TL;DR: Increased turnover of phospholipid fatty acids, following lymphocyte stimulation, requires a transferase to incorporate new fatty acids and a means of generating lysophosphatides and free fatty acids as substrates for this enzyme.
Journal ArticleDOI
Double-blind trial of linoleate supplementation of the diet in multiple sclerosis.
J. H. D. Millar,K. J. Zilkha,M. J. S. Langman,H. P. Wright,A. D. Smith,J. Belin,R. H. S. Thompson +6 more
TL;DR: Relapses tended to be less frequent and be significantly less severe and of shorter duration in the linoleate-supplemented group than in those receiving the oleate mixture, but clear evidence that treatment affected the overall rate of clinical deterioration was not obtained.
Journal ArticleDOI
Effect of low saturated fat diet in early and late cases of multiple sclerosis
Roy L. Swank,B. Brewer Dugan +1 more
TL;DR: Patients who adhered to the prescribed low-fat diet showed significantly less deterioration and much lower death rates than did those who consumed more fat than prescribed.
Journal ArticleDOI
Effect of dietary advice and n-3 supplementation in newly diagnosed MS patients.
TL;DR: It is suggested that fish oil supplementation given together with vitamins and dietary advice can improve clinical outcome in patients with newly diagnosed MS.
Journal ArticleDOI
Dietary interventions for multiple sclerosis
Mariangela Farinotti,Laura Vacchi,Silvana Simi,Carlo Di Pietrantonj,Lorenzo Brait,Graziella Filippini +5 more
TL;DR: PUFAs seem to have no major effect on the main clinical outcome in MS (disease progression), but they may tend to reduce the frequency of relapses over two years, however, the data that are available are insufficient to assess a real benefit or harm from PUFA supplementation.
References
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Journal ArticleDOI
Mortality and disability in multiple sclerosis: a statistical estimate of prognosis
TL;DR: The disease has been treated with glandular extracts, whole liver, numerous vitamins, penicillin, the sulfonamides, histamine, the antihistamines, goats' milk, bishydroxycoumarin (dicumarol®), neostigmine, and psychoanalysis, all of which are claimed to have cured some patients of their disease.
Journal ArticleDOI
Supravital analysis of disorders in the cerebral vascular permeability ii. two cases of multiple sclerosis
Journal ArticleDOI
Prognosis and treatment of multiple sclerosis-quantitative nosometric study.
TL;DR: Observations on the annual incidence favor the probability that the disease is endogenous and treatment study included the effect of vitamin therapy, blood transfusions, and corticotropin administration.
Journal ArticleDOI
Treatment of multiple sclerosis with low-fat diet; results of five and one-half years' experience.
TL;DR: The primary purpose of this paper is to report the results of five and one-half years' experience of treating multiple sclerosis with a low-fat diet, and the earlier cases seemed to benefit more than those with established disabilities.
Journal ArticleDOI
Changes in blood of dogs and rabbits by high fat intake.
TL;DR: The effect of large butter-fat meals on the blood of rabbits and dogs has been studied and marked distortion of the red blood cells with adhesiveness and aggregation was observed.
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Effect of low saturated fat diet in early and late cases of multiple sclerosis
Roy L. Swank,B. Brewer Dugan +1 more