Journal ArticleDOI
Multiple sclerosis: twenty years on low fat diet.
TLDR
The author's experience in treating cases of multiple sclerosis with a low fat diet for more than 20 years is assessed, both in treatment of the data and in conclusions.Abstract:
THIS paper assesses the author's experience in treating cases of multiple sclerosis with a low fat diet for more than 20 years. Previous reports of these studies 1-5 were preliminary in intent. The present paper is intended to be final, both in treatment of the data and in conclusions. Materials and Methods Patient Material.— Evaluation and discussion of the materials and methods were presented in detail in a previous paper. 4 The more pertinent points, however, will be included here. From December 1948 to April 1954, 264 patients with multiple sclerosis were examined at the Montreal Neurological Institute; 108 were seen only a few times. The remaining 156 patients maintained contact to and beyond April 1954, and no patients were added after this date. Two were rejected because of uncertain diagnosis, and eight were lost during the ensuing years. The remaining 146 patients are included in this report ofread more
Citations
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Book ChapterDOI
Fatty Acids and Immunity
TL;DR: Increased turnover of phospholipid fatty acids, following lymphocyte stimulation, requires a transferase to incorporate new fatty acids and a means of generating lysophosphatides and free fatty acids as substrates for this enzyme.
Journal ArticleDOI
Double-blind trial of linoleate supplementation of the diet in multiple sclerosis.
J. H. D. Millar,K. J. Zilkha,M. J. S. Langman,H. P. Wright,A. D. Smith,J. Belin,R. H. S. Thompson +6 more
TL;DR: Relapses tended to be less frequent and be significantly less severe and of shorter duration in the linoleate-supplemented group than in those receiving the oleate mixture, but clear evidence that treatment affected the overall rate of clinical deterioration was not obtained.
Journal ArticleDOI
Effect of low saturated fat diet in early and late cases of multiple sclerosis
Roy L. Swank,B. Brewer Dugan +1 more
TL;DR: Patients who adhered to the prescribed low-fat diet showed significantly less deterioration and much lower death rates than did those who consumed more fat than prescribed.
Journal ArticleDOI
Effect of dietary advice and n-3 supplementation in newly diagnosed MS patients.
TL;DR: It is suggested that fish oil supplementation given together with vitamins and dietary advice can improve clinical outcome in patients with newly diagnosed MS.
Journal ArticleDOI
Dietary interventions for multiple sclerosis
Mariangela Farinotti,Laura Vacchi,Silvana Simi,Carlo Di Pietrantonj,Lorenzo Brait,Graziella Filippini +5 more
TL;DR: PUFAs seem to have no major effect on the main clinical outcome in MS (disease progression), but they may tend to reduce the frequency of relapses over two years, however, the data that are available are insufficient to assess a real benefit or harm from PUFA supplementation.
References
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Journal ArticleDOI
Multiple sclerosis: assessment of treatment with a modified low-fat diet.
Roy L. Swank,R. B. Bourdillon +1 more
Journal ArticleDOI
Treatment of multiple sclerosis with low-fat diet: result of seven years' experience
TL;DR: Experimental therapy of chronic diseases demands patience and persistence if a definite conclusion is to be reached, and the period of therapy must bear some relationship to the normally expectancies.
Journal ArticleDOI
Preliminary studies of sludged blood in multiple sclerosis.
Leon Roizin,R. C. Abell,J. Winn +2 more
Journal ArticleDOI
Oxygen availability in brain tissues after lipid meals.
Roy L. Swank,Haruomi Nakamura +1 more
TL;DR: The available oxygen in the hamster's brain was studied polarographically employing the platinum electrode technique and the electrodes were permanently implanted.
Journal ArticleDOI
Life expectancy and probable disability in multiple sclerosis.
TL;DR: Clinical description provides the indispensable information of the disease, its nature and its course that is the basis for epidemiologic observations.
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Effect of low saturated fat diet in early and late cases of multiple sclerosis
Roy L. Swank,B. Brewer Dugan +1 more