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Journal ArticleDOI

Multiple sclerosis: twenty years on low fat diet.

Roy L. Swank
- 01 Nov 1970 - 
- Vol. 23, Iss: 5, pp 460-474
TLDR
The author's experience in treating cases of multiple sclerosis with a low fat diet for more than 20 years is assessed, both in treatment of the data and in conclusions.
Abstract
THIS paper assesses the author's experience in treating cases of multiple sclerosis with a low fat diet for more than 20 years. Previous reports of these studies 1-5 were preliminary in intent. The present paper is intended to be final, both in treatment of the data and in conclusions. Materials and Methods Patient Material.— Evaluation and discussion of the materials and methods were presented in detail in a previous paper. 4 The more pertinent points, however, will be included here. From December 1948 to April 1954, 264 patients with multiple sclerosis were examined at the Montreal Neurological Institute; 108 were seen only a few times. The remaining 156 patients maintained contact to and beyond April 1954, and no patients were added after this date. Two were rejected because of uncertain diagnosis, and eight were lost during the ensuing years. The remaining 146 patients are included in this report of

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Citations
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Fatty Acids and Immunity

TL;DR: Increased turnover of phospholipid fatty acids, following lymphocyte stimulation, requires a transferase to incorporate new fatty acids and a means of generating lysophosphatides and free fatty acids as substrates for this enzyme.
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Double-blind trial of linoleate supplementation of the diet in multiple sclerosis.

TL;DR: Relapses tended to be less frequent and be significantly less severe and of shorter duration in the linoleate-supplemented group than in those receiving the oleate mixture, but clear evidence that treatment affected the overall rate of clinical deterioration was not obtained.
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TL;DR: Patients who adhered to the prescribed low-fat diet showed significantly less deterioration and much lower death rates than did those who consumed more fat than prescribed.
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Effect of dietary advice and n-3 supplementation in newly diagnosed MS patients.

TL;DR: It is suggested that fish oil supplementation given together with vitamins and dietary advice can improve clinical outcome in patients with newly diagnosed MS.
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Dietary interventions for multiple sclerosis

TL;DR: PUFAs seem to have no major effect on the main clinical outcome in MS (disease progression), but they may tend to reduce the frequency of relapses over two years, however, the data that are available are insufficient to assess a real benefit or harm from PUFA supplementation.
References
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Journal ArticleDOI

Treatment of multiple sclerosis with low-fat diet: result of seven years' experience

TL;DR: Experimental therapy of chronic diseases demands patience and persistence if a definite conclusion is to be reached, and the period of therapy must bear some relationship to the normally expectancies.
Journal ArticleDOI

Oxygen availability in brain tissues after lipid meals.

TL;DR: The available oxygen in the hamster's brain was studied polarographically employing the platinum electrode technique and the electrodes were permanently implanted.
Journal ArticleDOI

Life expectancy and probable disability in multiple sclerosis.

TL;DR: Clinical description provides the indispensable information of the disease, its nature and its course that is the basis for epidemiologic observations.
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