Journal ArticleDOI
Nanotechnology is an important strategy for combinational innovative chemo-immunotherapies against colorectal cancer.
Ana I. Matos,Barbara Carreira,Carina Peres,Liane I.F. Moura,João Conniot,Thibaut Fourniols,Anna Scomparin,Águeda Martínez-Barriocanal,Diego Arango,João Pedro Conde,Véronique Préat,Ronit Satchi-Fainaro,Helena F. Florindo +12 more
TLDR
The emerging role of nanotechnology in the development of combinational therapies targeting and thereby regulating the function of the major players in CRC progression and immune evasion will be focused on.About:
This article is published in Journal of Controlled Release.The article was published on 2019-08-10. It has received 42 citations till now. The article focuses on the topics: Cancer.read more
Citations
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Role of capping agents in the application of nanoparticles in biomedicine and environmental remediation: recent trends and future prospects
TL;DR: A novel review article introduces few frequently used capping agents in the fabrication of nanoparticles and recent advancements in biomedicine and environmental remediation approaches of capped nanoparticles have been elaborated.
Journal ArticleDOI
Ferroptosis-driven nanotherapeutics for cancer treatment.
TL;DR: This work intends to outline the latest advances in ferroptosis-driven cancer nanotherapeutics at the intersection of ferroPTosis and bionanotechnology and highlight the future expectations and challenges.
Journal ArticleDOI
Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis
TL;DR: In this article, the authors focus on the different mechanisms of TAM in colorectal cancer, including switching of phenotypical subtypes, promoting tumor proliferation, invasion, and migration, facilitating angiogenesis, mediating immunosuppression, regulating metabolism, and interacting with the microbiota.
Journal ArticleDOI
Targeted Manganese doped silica nano GSH-cleaner for treatment of Liver Cancer by destroying the intracellular redox homeostasis.
Hongxia Tang,Chaoqun Li,Yue Zhang,Hongyue Zheng,Ying Cheng,Jingjing Zhu,Xiaojie Chen,Zhihong Zhu,Ji-Gang Piao,Fanzhu Li +9 more
TL;DR: Target sorafenib loaded manganese doped silica nanoparticle (FaPEG-MnMSN@SFB) was constructed, which could destroy the intracellular redox homeostasis by consuming GSH and cause multi-path programmed cell death and could be a promising strategy for cancer therapy.
Journal ArticleDOI
Emerging Theranostic Silver Nanomaterials to Combat Colorectal Cancer: A Systematic Review
Hamed Barabadi,Hossein Vahidi,Kaveh Damavandi Kamali,Masoumeh Rashedi,Omid Hosseini,Ahmad Reza Golnaraghi Ghomi,Muthupandian Saravanan +6 more
TL;DR: The findings of this study promise the bright future of biogenic AgNPs for colorectal cancer therapy as the science of synthesizing and utilizing nanoscale materials for cancer theranostics.
References
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Journal ArticleDOI
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
Herbert Hurwitz,Louis Fehrenbacher,William Novotny,Thomas Cartwright,John D. Hainsworth,W. Heim,Jordan Berlin,Ari David Baron,Susan Griffing,Eric Holmgren,Napoleone Ferrara,Gwen Fyfe,Beth Rogers,Robert W. Ross,Fairooz F. Kabbinavar +14 more
TL;DR: The addition of bevacizumab to fluorouracil-based combination chemotherapy results in statistically significant and clinically meaningful improvement in survival among patients with metastatic colorectal cancer.
Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
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Origin and Physiological Roles of Inflammation
TL;DR: This work has shown that tissue stress or malfunction induces an adaptive response that is intermediate between the basal homeostatic state and a classic inflammatory response, which is referred to here as para-inflammation.
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Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer.
David Cunningham,Yves Humblet,Salvatore Siena,David Khayat,Harry Bleiberg,Armando Santoro,D. Bets,M. Mueser,Andreas Harstrick,Chris Verslype,Ian Chau,Eric Van Cutsem +11 more
TL;DR: Cetuximab has clinically significant activity when given alone or in combination with irinotecan in patients with ir inotecans-refractory colorectal cancer.
Journal ArticleDOI
Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer
A. de Gramont,A. Figer,M. Seymour,M. Homerin,A. Hmissi,J. Cassidy,Corrado Boni,H. Cortes-Funes,Andrés Cervantes,Gilles Freyer,Demetris Papamichael,N. Le Bail,C. Louvet,D. Hendler,F. de Braud,C. Wilson,Francois Morvan,Andrea Bonetti +17 more
TL;DR: The LV5FU2-oxaliplatin combination seems beneficial as first-line therapy in advanced colorectal cancer, demonstrating a prolonged progression-free survival with acceptable tolerability and maintenance of QoL.