Journal ArticleDOI
Natural occurring 2-(2-phenylethyl) chromones, structure elucidation and biological activities.
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This review focuses on the naturally occurring PEC derivatives, their sources, physical and spectral data, as well as biological activities.About:
This article is published in Natural Product Research.The article was published on 2015-08-04. It has received 48 citations till now. The article focuses on the topics: Chromone.read more
Citations
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A new cytotoxic 2-（2-phenylethyl）chromone from Chinese eaglewood
TL;DR: Wang et al. as mentioned in this paper described 8-chloro-5,6,7,trihydroxy-2-(3-hydroxy)-4-methoxyphenethyl)-5, 6, 7, 8-tetrahydro-4H-chromen-4-one (1)
Journal ArticleDOI
Agarwood Induction: Current Developments and Future Perspectives.
TL;DR: This paper attempts to provide an overview for the past efforts toward the understanding of agarwood formation, the evolvement of induction methods and their further development prospects by integrating it with high-throughput omics approaches.
Journal ArticleDOI
Anti-inflammatory Dimeric 2-(2-Phenylethyl)chromones from the Resinous Wood of Aquilaria sinensis
Hui-Xia Huo,Zhi-Xiang Zhu,Yuelin Song,Shepo Shi,Jing Sun,Hui Sun,Yun-Fang Zhao,Jiao Zheng,Daneel Ferreira,Jordan K. Zjawiony,Pengfei Tu,Jun Li +11 more
TL;DR: Sixteen new 2-(2-phenylethyl)chromone dimers, including four pairs of enantiomers, along with eight optically pure analogues, were isolated from the resinous wood of Aquilaria sinensis and exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.
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Iodine‐Mediated Domino C(sp2)–H Sulfonylation/Annulation of Enaminones and Sulfonyl Hydrazines for the Synthesis of 3‐Sulfonyl Chromones
TL;DR: The radical C(sp2)-H sulfonylation and C( sp2)-N bond oxygenation enabling the chemo-selective synthesis of 3-sulfonyl chromones using enaminones and sulfonyl hydrazines have been accomplished.
References
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Journal ArticleDOI
Natural Products as Sources of New Drugs over the Last 25 Years
David J. Newman,Gordon M. Cragg +1 more
TL;DR: This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003 and is able to identify only one de novo combinatorial compound approved as a drug in this 25 plus year time frame.
Journal Article
The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
TL;DR: Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing.
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Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010
David J. Newman,Gordon M. Cragg +1 more
TL;DR: This review is an updated and expanded version of the three prior reviews and adds a new designation, "natural product botanical" or "NB", to cover those botanical "defined mixtures" that have now been recognized as drug entities by the FDA and similar organizations.
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Natural products to drugs: natural product derived compounds in clinical trials
Mark S. Butler,Mark S. Butler +1 more
TL;DR: Natural product and natural product-derived compounds that are being evaluated in clinical trials or are in registration (as at 31st December 2007) have been reviewed, as well as natural products for which clinical trials have been halted or discontinued since 2005.
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Flavonoid biosynthesis: ‘new’ functions for an ‘old’ pathway
TL;DR: These studies demonstrate the utility of flavonoid structures for a broad range of activities, and also highlight the value of the flavonoids pathway as a paradigm for studying the evolution of plant metabolism.